DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dhc36C and Dync1h1

DIOPT Version :9

Sequence 1:	NP_001369131.1	Gene:	Dhc36C / 35061	FlyBaseID:	FBgn0013810	Length:	4065	Species:	Drosophila melanogaster
Sequence 2:	NP_062099.3	Gene:	Dync1h1 / 29489	RGDID:	2511	Length:	4644	Species:	Rattus norvegicus

Alignment Length:	4473	Identity:	1131/4473 - (25%)
Similarity:	1962/4473 - (43%)	Gaps:	820/4473 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 QNPNREFSIPS-FTS------ICGGRRLCEKSKMLYTRPKPDVLQSILQSKAN---PEYKSRRLW 59
            :|.|..|.|.| |.:      |.|..|  |....|..|.|.|:  ..|..|..   |:.::.::.
  Rat   574 KNANEMFRIFSRFNALFVRPHIRGAIR--EYQTQLIQRVKDDI--ESLHDKFKVQYPQSQACKMS 634

  Fly    60 YELNMPECASSLLDGKMKSDLPDNILCAKKQQKKRQKKRESGVAKA--NYM---TMRLEREHFRR 119
            :..::|..:.|::..|.          ..:|.....|:.|..:.|.  |::   .::.:.:.||.
  Rat   635 HVRDLPPVSGSIIWAKQ----------IDRQLTAYMKRVEDVLGKGWENHVEGQKLKQDGDSFRM 689

  Fly   120 KLVELILHMDDDQDPELAAQCAVPFPDQEEREILRYYYYIKHGIDTI---HVSPLSKKILKRITD 181
            ||        :.|:          ..|...|::.:....:...|.||   .|...|..:||...:
  Rat   690 KL--------NTQE----------IFDDWARKVQQRNLGVSGRIFTIESARVRGRSGNVLKLKVN 736

  Fly   182 LVPPLL--------YKW-----QTALNENIAEVRADYVFAMKKAVVDFVLRH-TVLDRLTKEGVG 232
            .:|.::        .||     ..|:.....:....|.||:  ::::.|..: ...:::.:....
  Rat   737 FLPEIITLSKEVRNLKWLGFRVPLAIVNKAHQANQLYPFAI--SLIESVRTYERTCEKVEERNTI 799

  Fly   233 GKYDTAERREVQSM-----TNFWR-YRYDENRNVLMKTLFCIHRSVASILELWSMKYKDKSLIDS 291
            .......::|||::     ...|. |:.|.....|.:|:|.....|..:|           :|:.
  Rat   800 SLLVAGLKKEVQALIAEGIALVWESYKLDPYVQRLAETVFNFQEKVDDLL-----------IIEE 853

  Fly   292 KELAKVESPFSLFTFVYLCGSHIDNGKTLLEESWYGEIHSSLLKA------SKRGQLP------- 343
            |...:|.   ||.|.:|             :...:.||.:.:.||      .....||
  Rat   854 KIDLEVR---SLETCMY-------------DHKTFSEILNRVQKAVDDLNLHSYSNLPIWVNKLD 902

  Fly   344 -DIRRFTLVK--RFFNCVAALMTQQLEDICIRSLKEYADFICD---YGHSNPGFE------ISVM 396
             :|.|...|:  ........::..|.||      |...|...|   ..| .||.|      :..:
  Rat   903 MEIERILGVRLQAGLRAWTQVLLGQAED------KAEVDMDTDAPQVSH-KPGGEPKIKNVVHEL 960

  Fly   397 LADEDTIQFNPSFSKVQSELLRVIDSIMLSIQMLPRIESKLYT-----DLIVSKKIFLTPTVPES 456
            ......|..||...:.:.:|.:.:.:..:.:..||||:|:.|.     :|...:|.:
  Rat   961 RITNQVIYLNPPIEECRYKLYQEMFAWKMIVLSLPRIQSQRYQVGVHYELTEEEKFY-------- 1017

  Fly   457 IVQETKNRICAMLEEQRIGPELRLQDFDPFIDLINGSDAERVGNFMESDATFEQYADMVYEYKEK 521
                 :|.:..|.:    ||....:.:...:.::               ...|||..:..:|:..
  Rat  1018 -----RNALTRMPD----GPVALEESYSAVMGIV---------------TEVEQYVKVWLQYQCL 1058

  Fly   522 EDRIAKEVWAVIRMGFYEFHRDKFITHLESLCRQLQLDLLARMVTDQQARITRLGK---EYDAIA 583
            .|..|:.::.  |:|       :.::..::|..|::   .||...|........|.   :|..:.
  Rat  1059 WDMQAENIYN--RLG-------EDLSKWQALLVQIR---RARGTFDNAETKKEFGPVVIDYGKVQ 1111

  Fly   584 KKALTVPKDTAELMQLKAYVVHAEENLVPEMEARLKVNMSEILWLMDHTLYSPLEIKNNSNSFQW 648
            .|           :.||....|.|  ::.:....|..||:|.     |:..|
  Rat  1112 SK-----------VNLKYDSWHKE--VLSKFGQMLGSNMTEF-----HSQIS------------- 1145

  Fly   649 YLKLPSIFEQHRAIIAE-----KVIEYQELLKKRIELFRRELQNYYE-----QVQTYD------- 696
              |.....|||....|.     ..|.|.:.||::|:.|.::::.|..     :.|.:.
  Rat  1146 --KSRQELEQHSVDTASTSDAVTFITYVQSLKRKIKQFEKQVELYRNGQRLLEKQRFQFPPSWLY 1208

  Fly   697 ------TWGDIKQLSRYKKRAGVLDQRLVQAMETIDQINEEETSYGWD-LSQYPMRKKAHDQLKP 754
                  .||....:.|.|..|  :.|::......|.|.:....|...| |:.:...|.....|:|
  Rat  1209 IDNIEGEWGAFNDIMRRKDSA--IQQQVANLQMKIVQEDRAVESRTTDLLTDWEKTKPVTGNLRP 1271

  Fly   755 YK-----TLFDA--------------GQDFMDKWDLWMHS------QVGSFDPDEIDGDVSNFYR 794
            .:     |:::.              .::.::..|..:.|      ||...:..::.|..|...:
  Rat  1272 EEALQALTIYEGKFGRLKDDREKCAKAKEALELTDTGLLSGSEERVQVALEELQDLKGVWSELSK 1336

  Fly   795 IIQKLDKQMGDHP-ITMQ----------LIQDVK---AQIEAF----------REHMPI---INT 832
            :.:::| ||.:.| :::|          |:..:|   |::..:          :.:|.|   :..
  Rat  1337 VWEQID-QMKEQPWVSVQPRKLRQNLDGLLNQLKNFPARLRQYASYEFVQRLLKGYMKINMLVIE 1400

  Fly   833 LGNPGMKARHWELVSEIIGFPIKVSPELTLEKIIEYQLDEYVPKFEAISES----ATKENNLERA 893
            |.:..:|.|||:.:.:.:.....|| ||||.:|.:..|.    |.|||.:.    |..|..||..
  Rat  1401 LKSEALKDRHWKQLMKRLHVNWVVS-ELTLGQIWDVDLQ----KNEAIVKDVLLVAQGEMALEEF 1460

  Fly   894 MAKMVNEWEGVEFSISPYRDSGTFKLAAVDDIQILLDDQIIKTQTMKSSPYIKPFEADIIKWEAK 958
            :.::...|...|..:..|::.... :...||:...:.:.|.....||.|||.|.||.|.:.||.|
  Rat  1461 LKQIREVWNTYELDLVNYQNKCRL-IRGWDDLFNKVKEHINSVSAMKLSPYYKVFEEDALSWEDK 1524

  Fly   959 LMLLQEILDEWLRVQATWMYLEPIFS-SPDIQQQMPEEGRRFSAVDKIWKELMKQVSQDPKVMVV 1022
            |..:..:.|.|:.||..|:|||.||: |.||:..:|.|.:||.::...:..|||:||:.|.||.|
  Rat  1525 LNRIMALFDVWIDVQRRWVYLEGIFTGSADIKHLLPVETQRFQSISTEFLALMKKVSKSPLVMDV 1589

  Fly  1023 VQIDKMNDKLKKAYSLLEVIQKGLNAYLEKKRLYFPRFFFLSNDELLEILSETKDPTRVQIHLKK 1087
            :.|..:...|::...||..|||.|..|||::|..||||:|:.:::||||:..:|:..::|.|.||
  Rat  1590 LNIQGVQRSLERLADLLGKIQKALGEYLERERSSFPRFYFVGDEDLLEIIGNSKNVAKLQKHFKK 1654

  Fly  1088 CFEGIATLNFTEELDVT-AMRSSEREEVTLVDVISTSKARGQVEKWLLELEIDMKKSVHHKVSEA 1151
            .|.|::::...|:..|. .:.|.|.|||.....:|.:: ..::.:||..:|.:|:.::...::|:
  Rat  1655 MFAGVSSIILNEDSSVVLGISSREGEEVMFKTPVSITE-HPKINEWLTLVEKEMRVTLAKLLAES 1718

  Fly  1152 F--------------YSYLKMLRHVWVLTWPGQCVQSISLTYWTLEITECFESEEPKEN------ 1196
            .              .:|:     .|:..:..|.|...:...|:..:      |....|
  Rat  1719 VTEVEIFGKATSIDPNTYI-----TWIDKYQAQLVVLSAQIAWSENV------ENALSNVGGGGD 1772

  Fly  1197 ---LAKYLQKCVLQINKIVDLVRGDLNTQNRITLGALVVLDVHARDVLAEIVANQVEDLQDFQWL 1258
               |...|....:.:|.:.|.|..:.....|..|..|:...||.|||...::.:::::.:.|:||
  Rat  1773 VGPLQSVLSNVEVTLNVLADSVLMEQPPLRRRKLEHLITELVHQRDVTRSLIKSKIDNAKSFEWL 1837

  Fly  1259 CQLRYYWEDNNLDT------RMINCSLPYGYEYLGNTPRLVVTPLTDRCYRTLFAALNLHLGGAP 1317
            .|:|:|::....|.      :|.|....||:||||...:||.||||||||.|:..||...|||:|
  Rat  1838 SQMRFYFDPKQTDVLQQLSIQMANAKFNYGFEYLGVQDKLVQTPLTDRCYLTMTQALEARLGGSP 1902

  Fly  1318 EGPAGTGKTETTKDLAKAVAKQCVVFNCSDGLDYLALGKFFKGLASCGAWSCFDEFNRIDLEVLS 1382
            .|||||||||:.|.|...:.:..:||||.:..|:.|:|:.|.||...|||.|||||||::..:||
  Rat  1903 FGPAGTGKTESVKALGHQLGRFVLVFNCDETFDFQAMGRIFVGLCQVGAWGCFDEFNRLEERMLS 1967

  Fly  1383 VVAQQILTIQRGINSGS-PTLVFEGTTLT---------LDPTCAVFITMNPGYAGRSELPDNLKA 1437
            .|:||:..||..:...| |........:|         :.|..|:||||||||||||.||||||.
  Rat  1968 AVSQQVQCIQEALREHSNPNYDKTSAPITCELLNKQVKVSPDMAIFITMNPGYAGRSNLPDNLKK 2032

  Fly  1438 LFRSVAMMVPDYALISEIELYSYGFLTAKPLSVKIVATYRLCSEQLSTQCHYDYGMRAVKSVLKA 1502
            ||||:||..||..||:::.|||.||.||:.|:.|||..::||.||||:|.|||:|:||:||||.:
  Rat  2033 LFRSLAMTKPDRQLIAQVMLYSQGFRTAEVLANKIVPFFKLCDEQLSSQSHYDFGLRALKSVLVS 2097

  Fly  1503 AGALK-------LRYRDEN--------------EDILVLRSIKDVNLPKFLNQDIPLFQGITSDL 1546
            ||.:|       .|.::|.              |..::::|:.:..:||.:.:||||...:.||:
  Rat  2098 AGNVKRERIQKIKREKEERGEAVDEGEIAENLPEQEILIQSVCETMVPKLVAEDIPLLFSLLSDV 2162

  Fly  1547 FPGTVLPEADYVLFNKCTQMACER------QNKQCTPFVLEKVQQLYEMIVVRHGLMLVGYPFGG 1605
            |||......:.....:..:..|:.      ..::.....:|||.|||::..:.||||:||....|
  Rat  2163 FPGVQYHRGEMTALREELKKVCQEMYLTYGDGEEVGGMWVEKVLQLYQITQINHGLMMVGPSGSG 2227

  Fly  1606 KTTTYRVLAEALECMEKTDGSENKAIYTVINPKAITMGQLYGQFDAVSHEWSDGI-------LAV 1663
            |:..:|||.:|||.:|..:|     :..:|:||||:...|||..|..:.||:||:       :..
  Rat  2228 KSMAWRVLLKALERLEGVEG-----VAHIIDPKAISKDHLYGTLDPNTREWTDGLFTHVLRKIID 2287

  Fly  1664 NYRIFAISDSPDRKWLIFDGPVDAIWIENMNTVLDDNKKLCLMSGEIIQLSNTTNLVFEPMDLEV 1728
            |.|    .:...|:|::|||.||..|:||:|:||||||.|.|.:||.:.|.....::||..||:.
  Rat  2288 NVR----GELQKRQWIVFDGDVDPEWVENLNSVLDDNKLLTLPNGERLSLPPNVRIMFEVQDLKY 2348

  Fly  1729 ASPATVSRCGMIYLEPSSLGWEPLVASWKNTLPAAFHTVSKQLISMLISRFCPI----------- 1782
            |:.||||||||::.....|..:.:           |:....:|      |..|:
  Rat  2349 ATLATVSRCGMVWFSEDVLSTDMI-----------FNNFLARL------RSIPLDEGEDEAQRRR 2396

  Fly  1783 -------------LLFILRKSLKEIAPTSDANLMVS--------------------LMNFFECFI 1814
                         :|.|.|.:...:.|...:|.:|:                    |.:.|....
  Rat  2397 KGKEDEGEEAASPMLQIQRDAATIMQPYFTSNGLVTKALEHAFKLEHIMDLTRLRCLGSLFSMLH 2461

  Fly  1815 DDFRDEKYVA--NVSDLDFRAQTEGI-------FLFSCIWSLGGSLDADSREKFNIIFRALMEKT 1870
            ...|:   ||  |.:..||..|.|.:       .:::.:|||.|    |||.|    .||.:.:
  Rat  2462 QACRN---VAQYNANHPDFPMQIEQLERYIQRYLVYAILWSLSG----DSRLK----MRAELGE- 2514

  Fly  1871 FPQSLYDTYGVPEDLYVESLAKPFIFPIPKQGSVFDYRYIKEGKGKWKPWQDDVNSAPPIPRDIP 1935
                           |:..:.   ..|:|...::....|.....|:|.|||..|.........:.
  Rat  2515 ---------------YIRRIT---TVPLPTAPNIPIIDYEVSISGEWSPWQAKVPQIEVETHKVA 2561

  Fly  1936 VNQIIIQTNESVRIGAVLDLLNRHGKPIMLVGPTGTGKSVYVIDYMLKKMDLSFYKPLLISFSAQ 2000
            ...:::.|.::||..|:|.......||::|.||.|:||::.:...:....|:   :.:.::||:.
  Rat  2562 APDVVVPTLDTVRHEALLYTWLAEHKPLVLCGPPGSGKTMTLFSALRALPDM---EVVGLNFSSA 2623

  Fly  2001 TSANQTQDIIMSKLDK----RR--KGVFGPP--LNSRFVIFVDDVSMPLKENYGAQPPIELLRMM 2057
            |    |.::::...|.    ||  .||...|  |....|:|.|::::|..:.||.|..|..:|.|
  Rat  2624 T----TPELLLKTFDHYCEYRRTPNGVVLAPVQLGKWLVLFCDEINLPDMDKYGTQRVISFIRQM 2684

  Fly  2058 LDHMMWYDRKNIVPMKLIDLQMIVAMGPPST--GNTVTPRFQRFFNVISID------------DF 2108
            ::|..:|...:...:||..:|.:.|..||:.  ...::.||.|...|:.:|            .|
  Rat  2685 VEHGGFYRTSDQTWVKLERIQFVGACNPPTDPGRKPLSHRFLRHVPVVYVDYPGPASLTQIYGTF 2749

  Fly  2109 NNDILNTIFSKIVLWHLDTRGFSKEFDPCIDEIVGATLTIYNDAKLNLLPTPAKSHYLFNLRDFS 2173
            |..:|..|.|        .|.::       :.:..|.:..|..:: .......:.||:::.|:.:
  Rat  2750 NRAMLRLIPS--------LRTYA-------EPLTAAMVEFYTMSQ-ERFTQDTQPHYIYSPREMT 2798

  Fly  2174 RVIQGVLLSV-PEATEDVNSMRRLWVHEVLRVYGDRLVEDADRSWLFENICSTVKSCFNTDPSRL 2237
            |.::|:..:: |..|..|..:.|:|.||.||::.||||||.:|.|..|||.......|   |:
  Rat  2799 RWVRGIFEALRPLETLPVEGLIRIWAHEALRLFQDRLVEDEERRWTDENIDMVALKHF---PN-- 2858

  Fly  2238 FGRLVEKDKSLQESDFRQLIYCDFTNPKADTKNYVEVQDLEELRRVVEAYL-VEYNNMSKKPMNL 2301
                ::|:|::.    |.::|.::.     :|:|:.| |.||||..|:|.| |.|......|  |
  Rat  2859 ----IDKEKAMS----RPILYSNWL-----SKDYIPV-DQEELRDYVKARLKVFYEEELDVP--L 2907

  Fly  2302 VLFRFAIEHLSRICRIIKQPRSHALLIGVGGSGRQSLTRLASHICDYELFQVEITRLYGPYEYHE 2366
            |||...::|:.||.||.:||:.|.|||||.|:|:.:|:|..:.:....::|:::.|.|...::.|
  Rat  2908 VLFNEVLDHVLRIDRIFRQPQGHLLLIGVSGAGKTTLSRFVAWMNGLSVYQIKVHRKYTGEDFDE 2972

  Fly  2367 DIKAILRKIGASEMHGVFLFTDVQIKDESFLEDISNLLNSGEVPNLFTNEEKIEVQEKMAQIDKQ 2431
            |::.:||:.|.......|:..:..:.|..|||.::.||.:||||.||..:|       .|.:..|
  Rat  2973 DLRTVLRRSGCKNEKIAFIMDESNVLDSGFLERMNTLLANGEVPGLFEGDE-------YATLMTQ 3030

  Fly  2432 RDKAVQTDG----SPVALFNFFVTTCKDQLHIVLAMSPIGDALRNRIRKFPSIVNCCTIDWFQSW 2492
            ..:..|.:|    |...|:.:|.:.....||:|..|:|..:.|::|....|::.|.|.::||..|
  Rat  3031 CKEGAQKEGLMLDSHEELYKWFTSQVIRNLHVVFTMNPSSEGLKDRAATSPALFNRCVLNWFGDW 3095

  Fly  2493 PEDALLAVSTRFLASEDL--------------------TALERRTAIDMCMEFHTSTQELSAKFF 2537
            ..:||..|...|.:..||                    ....|...::.|:..|.:..:.:|:..
  Rat  3096 STEALYQVGKEFTSKMDLEKPNYIVPDYMPVVYDKLPQPPTHREAIVNSCVFVHQTLHQANARLA 3160

  Fly  2538 SRLHRYNYVTPTSYLELIQTFKALLSQKRNNITNNRNRYLTGISQLDIAAQQVAVMQEQLIALEP 2602
            .|..|...:||..||:.|..:..|..:||:.:...:.....|:.::.....||..::..|.....
  Rat  3161 KRGGRTMAITPRHYLDFINHYANLFHEKRSELEEQQMHLNVGLRKIKETVDQVEELRRDLRIKSQ 3225

  Fly  2603 KLKEASEIVAEQVAKVTADSKLAEEQREI-VKLDESAAKEQAAVAQE---IKDECDAKLGEALPI 2663
            :|:..:....:::.|:..|.:.||:::.: .::.|...|:|..:|.:   :|::.|    :..|.
  Rat  3226 ELEVKNAAANDKLKKMVKDQQEAEKKKVMSQEIQEQLHKQQEVIADKQMSVKEDLD----KVEPA 3286

  Fly  2664 LESALAALNTLTTADIAVVKTMKSPPIGVRIVMEAVCILKDVKPDKVPNPSGLGTVEDYWGPSKR 2728
            :..|..|:.::....:..|::|.:||..|::.:|::|:|             ||.....|...:.
  Rat  3287 VIEAQNAVKSIKKQHLVEVRSMANPPAAVKLALESICLL-------------LGESTTDWKQIRS 3338

  Fly  2729 VLSDMKFLDSLLNFDKDNIPVEVMKKLAQRILSNEAFDPDKIKSASTACEGLCRWVIALTKYDVV 2793
            ::....|:.:::||..:.|...:.:|:.:..:||.:::.:.:..||.||..:.:|.||...|..:
  Rat  3339 IIMRENFIPTIVNFSAEEISDAIREKMKKNYMSNPSYNYEIVNRASLACGPMVKWAIAQLNYADM 3403

  Fly  2794 AKIVAPKKLALAEAEATYNAAMKTLNEKLAMLAKVEANLAAIQKILDEQLRQYGILLAEHE---- 2854
            .|.|.|.:..|.:.|.......:..||...|:..:||::|..::       :|.:|::|.:
  Rat  3404 LKRVEPLRNELQKLEDDAKDNQQKANEVEQMIRDLEASIARYKE-------EYAVLISEAQAIKA 3461

  Fly  2855 ---ACTKKLQRAQELISGLGGERTRWSETAKMLQASFKSVTGDVLISSGVVSYLGPFTIDFRVDQ 2916
               |...|:.|:..|:..|..||.||.:|::..:....::.||.|:|:..::|.|.|....|.:.
  Rat  3462 DLAAVEAKVNRSTALLKSLSAERERWEKTSETFKNQMSTIAGDCLLSAAFIAYAGYFDQQMRQNL 3526

  Fly  2917 IRKWVTKCLNFGVTCTADFQLAVVLGEPVEIRFWNICGLPTDAFSIESAIMMKNARRWPLMIDPQ 2981
            ...|........:....|......|....|...|....||.|....|:|||:|...|:||:|||.
  Rat  3527 FTTWSHHLQQANIQFRTDIARTEYLSNADERLRWQASSLPADDLCTENAIMLKRFNRYPLIIDPS 3591

  Fly  2982 GQANKWIKNYEKNNKLCVIRLNQADYTRVMENAIQFGLPVLLENIGEELDPVLESVLQKTLFKQG 3046
            |||.::|.|..|:.|:.........:.:.:|:|::||.|:|:::: |..||||..||.:.:.:.|
  Rat  3592 GQATEFIMNEYKDRKITRTSFLDDAFRKNLESALRFGNPLLVQDV-ESYDPVLNPVLNREVRRTG 3655

  Fly  3047 GALCIKLGDSVIEYNHSFRFYMTTKLRNPHYLPEVAVKVTLLNFMITTQGLQDQLLGITVARERP 3111
            |.:.|.|||..|:.:.||..:::|:.....:.|::..:||.:||.:|...||.|.|...:..|||
  Rat  3656 GRVLITLGDQDIDLSPSFVIFLSTRDPTVEFPPDLCSRVTFVNFTVTRSSLQSQCLNEVLKAERP 3720

  Fly  3112 DLEAEKNNLIVQGADNKRMLKETEDQILEVLSSAE-NILEDETAVQILSSAKALANDISEKQVIT 3175
            |::.::::|:....:.:..|::.|..:|:.|:..: .||:|:|.:..|.:.|..|.:::.|...|
  Rat  3721 DVDEKRSDLLKLQGEFQLRLRQLEKSLLQALNEVKGRILDDDTIITTLENLKREAAEVTRKVEET 3785

  Fly  3176 EATEKQIDIARLSYVPIAEHSTILFFTIVELANIDPMYQYSLVWFVNLY----------MSSIDN 3230
            :...::::.....|:|::...:.::||:..|..:..:|||||.:|:::|          ..:.|:
  Rat  3786 DIVMQEVETVSQQYLPLSTACSSIYFTMESLKQVHFLYQYSLQFFLDIYHNVLYENPNLKGATDH 3850

  Fly  3231 TEKVDDIAARLLDLRNHFTYSLYVNICRSLFERDKLLFSLILNINMMK-------HDNRIDNAEW 3288
            |:::..|...|..:       .:..:.|.:..:|.:.|:::|....:|       :|     ||:
  Rat  3851 TQRLSVITKDLFQV-------AFNRVARGMLHQDHITFAMLLARIKLKGTMGEPTYD-----AEF 3903

  Fly  3289 MFLLTGGVGLENPYKNP-TTWLGVQNWDELCRLTNLTNFKGL--REDFNENSAQWKPFFDSKSPQ 3350
            ...|.|...:.:....| ...|.|:..:.:.||:.|..||.|  :...:|....|   .:|.||:
  Rat  3904 QHFLRGKEIVLSAGSTPKVQGLTVEQAEAVARLSCLPAFKDLIAKVQADEQFGIW---LESSSPE 3965

  Fly  3351 DNKDIPKSWDNRV------SVFQKLLLLRVFRPDKLVPAVLNFVSGELGERFVDPPQFDLMASFA 3409
              :.:|..|....      ....:|||::.||||:|:.....|||..|||.|:     .:|....
  Rat  3966 --QTVPYLWTEETPATPIGQAIHRLLLIQAFRPDRLLAMAHMFVSTNLGESFM-----SIMEQPL 4023

  Fly  3410 D-SHCC-------VPLIFILTPGSDPTATLLKFAEDQGFGTNRLFSLSLGQGQG-PIAMKMIDEG 3465
            | :|..       .|::....||.|.:..:...|.:|   ..::.|:::|..:| ..|.|.|:..
  Rat  4024 DLTHIVGTEVKPNTPVLMCSVPGYDASGHVEDLAAEQ---NTQITSIAIGSAEGFNQADKAINTA 4085

  Fly  3466 VKMGNWVVLQNCHLAASFMPLLEKICENLLPDATHPDFRLWLTSYPADHFPVVVLQNGIKMTNEP 3530
            ||.|.||:|:|.|||..::..|||...:|.|   |..|||:||.......||.:|:.|.....||
  Rat  4086 VKSGRWVMLKNVHLAPGWLMQLEKKLHSLQP---HACFRLFLTMEINPKVPVNLLRAGRIFVFEP 4147

  Fly  3531 PKGLRSNILRSMISDPISDPEWYESCTQPRIFKQLIYSLCFFHAVIQERRYFGPIGWNIPYEFNE 3595
            |.|:::|:||:..|.|:|     ..|..|....:|.:.|.:||||||||..:.|:||:..|||.|
  Rat  4148 PPGVKANMLRTFSSIPVS-----RMCKSPNERARLYFLLAWFHAVIQERLRYAPLGWSKKYEFGE 4207

  Fly  3596 TDLRISLMQLRMFLNQY---------ETVNYDALRYLTGECNYGGRVTDDWDRRTLKTILDKFYC 3651
            :|||.:...:..:|:..         :.:.:.||:.|..:..|||||.:::|:|.|.|.|::.:.
  Rat  4208 SDLRSACDTVDTWLDDTAKGRQNISPDKIPWSALKTLMAQSIYGGRVDNEFDQRLLNTFLERLFT 4272

  Fly  3652 PAVIDLETPYYLDETGLYYVPVFKEVDL--------YLNFTRDLPQISAPAIFGFHANAD-IMKD 3707
            ....|.|........|      .|::.:        ::.:...||....|:..|...||: ::..
  Rat  4273 TRSFDSEFKLACKVDG------HKDIQMPDGIRREEFVQWVELLPDAQTPSWLGLPNNAERVLLT 4331

  Fly  3708 QKETDMLLSHTLLTQKLEKKQRV-YVETLSRRFPENLS--LPTYPTCPPFLALYQMSLKDTSASS 3769
            .:..|| :|..|..|.||.:..: |.||..:...::.|  .|.:           |....|:||:
  Rat  4332 TQGVDM-ISKMLKMQMLEDEDDLAYAETEKKTRTDSTSDGRPAW-----------MRTLHTTASN 4384

  Fly  3770 DDSGGSKALTPEEVVTNVATDILDKLPKLFDRDAALLKYPTLYHQSMNTVLVQEMVRFNVL---- 3830
            ......:.|:|   :.....:|.|.|.:.|:|:.           .|...|:|: ||.::.
  Rat  4385 WLHLIPQTLSP---LKRTVENIKDPLFRFFEREV-----------KMGAKLLQD-VRQDLADVVQ 4434

  Fly  3831 --------LNTIRTSLITLRKGIKGLVVMSPAVEAVYKSVLIAKIPAMWAGKSYPSLKPLGSYVT 3887
                    .|.:||.:..|.|||                     :|..|:..:.|:...:..:|:
  Rat  4435 VCEGKKKQTNYLRTLINELVKGI---------------------LPRSWSHYTVPAGMTVIQWVS 4478

  Fly  3888 DFLRRLEFLQHWFDHGAPS--------TFWLSGFFFTQAFLTGAQQNYARKYVISIDLLAFDYEV 3944
            ||..|::.||:.....|..        ...|.|.|..:|::|..:|..|:....|::.|..:
  Rat  4479 DFSERIKQLQNISQAAAAGGAKELKNIHVCLGGLFVPEAYITATRQYVAQANSWSLEELCLE--- 4540

  Fly  3945 LTVEEPQRQGLSGPEDGVFVYGIFLEGARWDRTGKYLAESRPRELFDTMPLIWLKPLKRVDLPER 4009
            :.|...|...|.....|  |.|:.|:||........|:.:    :...:||..|:..|:....::
  Rat  4541 VNVTASQSTTLDACSFG--VTGLKLQGATCSNNKLSLSNA----ISTVLPLTQLRWGKQTSAEKK 4599

  Fly  4010 HNYL-CPMYKTAERRGVLSTTGHSTNFVVAMLLLCNPNTPVSHWIIRGTALLC 4061
            .:.: .|:|....|..::.|    .:|.:|     ....|.|.: .||.|:||
  Rat  4600 ASVVTLPVYLNFTRADLIFT----VDFEIA-----TKEDPRSFY-ERGVAVLC 4642

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dhc36C	NP_001369131.1	DHC_N2	746..1151	CDD:400618	126/462 (27%)
		DYN1	<984..3651	CDD:227570	820/2898 (28%)
		AAA_6	1281..1607	CDD:403853	154/362 (43%)
		AAA_8	2299..2561	CDD:403858	80/285 (28%)
		AAA_9	2950..3165	CDD:403859	70/215 (33%)
		Dynein_C	3779..4061	CDD:408026	62/302 (21%)
Dync1h1	NP_062099.3	Stem. /evidence=ECO:0000250	2..1865		306/1456 (21%)
		DHC_N1	238..830	CDD:285571	53/289 (18%)
		Interaction with DYNC1I2. /evidence=ECO:0000269\|PubMed:10893223	446..701		31/158 (20%)
		Interaction with DYNC1LI2. /evidence=ECO:0000269\|PubMed:10893223	649..800		28/180 (16%)
		DYN1	1044..4327	CDD:227570	950/3519 (27%)
		DHC_N2	1321..1719	CDD:285579	119/405 (29%)
		P-loop_NTPase	1866..2103	CDD:304359	124/236 (53%)
		AAA 1. /evidence=ECO:0000250	1866..2097		122/230 (53%)
		AAA 2. /evidence=ECO:0000250	2178..2450		84/297 (28%)
		P-loop_NTPase	2217..2357	CDD:304359	61/148 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2389..2409		0/19 (0%)
		AAA 3. /evidence=ECO:0000250	2554..2803		60/271 (22%)
		P-loop_NTPase	2565..2826	CDD:304359	66/283 (23%)
		AAA 4. /evidence=ECO:0000250	2897..3166		77/277 (28%)
		P-loop_NTPase	2907..3185	CDD:304359	80/284 (28%)
		Stalk. /evidence=ECO:0000250	3187..3498		70/334 (21%)
		MT	3199..3530	CDD:289543	76/354 (21%)
		AAA 5. /evidence=ECO:0000250	3551..3780		73/229 (32%)
		AAA_9	3559..3774	CDD:289547	70/215 (33%)
		Dynein_heavy	3920..4630	CDD:281078	201/802 (25%)
		AAA 6. /evidence=ECO:0000250	4003..4219		79/231 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5245
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100025
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.710