DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dhc36C and DYNC1H1

DIOPT Version :9

Sequence 1:	NP_001369131.1	Gene:	Dhc36C / 35061	FlyBaseID:	FBgn0013810	Length:	4065	Species:	Drosophila melanogaster
Sequence 2:	NP_001367.2	Gene:	DYNC1H1 / 1778	HGNCID:	2961	Length:	4646	Species:	Homo sapiens

Alignment Length:	4562	Identity:	1145/4562 - (25%)
Similarity:	1978/4562 - (43%)	Gaps:	951/4562 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 QKKRESGV--------------AKANYM-TMRLEREHFRRKLVELILHMDDDQDPELAA-----Q 139
            ::|||..:              |:.:.| ..|.:.|..|..:|.::       .|::.|     |
Human   439 KRKREENLKMVWRINPAHRKLQARLDQMRKFRRQHEQLRAVIVRVL-------RPQVTAVAQQNQ 496

  Fly   140 CAVPFP-DQEEREIL-------------RYYYYIKHGIDTIHVS--------PLSKKILKRI--- 179
            ..||.| |.:..|:|             ..|..:|. :|.:.||        ...|:..:||
Human   497 GEVPEPQDMKVAEVLFDAADANAIEEVNLAYENVKE-VDGLDVSKEGTEAWEAAMKRYDERIDRV 560

  Fly   180 -TDLVPPLLYKWQTALNENIAEVRADYVFAMKKAVVDFVLRHTVLDRLTKEGVGGKYDT----AE 239
             |.:...|..:..||.|.|    ....:|:...|:  ||..|.       .|...:|.|    ..
Human   561 ETRITARLRDQLGTAKNAN----EMFRIFSRFNAL--FVRPHI-------RGAIREYQTQLIQRV 612

  Fly   240 RREVQSMTNFWRYRYDENRNVLMKTLFCIHRSVASILELWSMKYKDKSLIDSKELAKVESPFSLF 304
            :.:::|:.:.::.:|.:::...|..:..:.....||  :|: |..|:.|  :..:.:||.
Human   613 KDDIESLHDKFKVQYPQSQACKMSHVRDLPPVSGSI--IWA-KQIDRQL--TAYMKRVED----- 667

  Fly   305 TFVYLCGSHIDNGKTLLEESWYGEIHSSLLKASKRGQLPDIRRFTLVKRFFNCVAALMTQQLEDI 369
                           :|.:.|...:....||       .|...|.:         .|.||::.|.
Human   668 ---------------VLGKGWENHVEGQKLK-------QDGDSFRM---------KLNTQEIFDD 701

  Fly   370 CIRSLKEYADFICDYGHSNPGFEISVMLADEDTIQFNPSFSKVQSELLRVIDSIMLSIQMLPRIE 434
            ..|.:::.     :.|.|...|.|      |.|        :|:.   |..:.:.|.:..||.|
Human   702 WARKVQQR-----NLGVSGRIFTI------EST--------RVRG---RTGNVLKLKVNFLPEI- 743

  Fly   435 SKLYTDLIVSKKI----FLTPTVPESIVQE-------------------TKNRICAMLEEQR--- 473
                  :.:||::    :|...||.:||.:                   |..|.|..:||:.
Human   744 ------ITLSKEVRNLKWLGFRVPLAIVNKAHQANQLYPFAISLIESVRTYERTCEKVEERNTIS 802

  Fly   474 ---IGPELRLQ--------------DFDPFIDLINGSDAERVGNFMES-----------DATFEQ 510
               .|.:..:|              ..||::..:    ||.|.||.|.           |.....
Human   803 LLVAGLKKEVQALIAEGIALVWESYKLDPYVQRL----AETVFNFQEKVDDLLIIEEKIDLEVRS 863

  Fly   511 YADMVYEYK---EKEDRIAKEV------------------------------------WAVIRMG 536
            ....:|::|   |..:|:.|.|                                    |..:.:|
Human   864 LETCMYDHKTFSEILNRVQKAVDDLNLHSYSNLPIWVNKLDMEIERILGVRLQAGLRAWTQVLLG 928

  Fly   537 FYEFHRDKFITHLESLCRQLQLDLLARMVTDQ------------QARIT---------------R 574
            ..|   ||         .::.:|..|..|:.:            :.|||               :
Human   929 QAE---DK---------AEVDMDTDAPQVSHKPGGEPKIKNVVHELRITNQVIYLNPPIEECRYK 981

  Fly   575 LGKEYDAIAKKALTVPKDTAELMQLKAYVVHAEE--------------------------NLVPE 613
            |.:|..|.....|::|:..::..|:..:....||                          .:|.|
Human   982 LYQEMFAWKMVVLSLPRIQSQRYQVGVHYELTEEEKFYRNALTRMPDGPVALEESYSAVMGIVSE 1046

  Fly   614 MEARLKVNMS-EILWLMD-HTLYSPL------------EIKNNSNSF------------------ 646
            :|..:||.:. :.||.|. ..:|:.|            :|:....:|
Human  1047 VEQYVKVWLQYQCLWDMQAENIYNRLGEDLNKWQALLVQIRKARGTFDNAETKKEFGPVVIDYGK 1111

  Fly   647 ----------QWYLKLPSIF----------------------EQHRAIIAE-----KVIEYQELL 674
                      .|:.::.|.|                      |||....|.     ..|.|.:.|
Human  1112 VQSKVNLKYDSWHKEVLSKFGQMLGSNMTEFHSQISKSRQELEQHSVDTASTSDAVTFITYVQSL 1176

  Fly   675 KKRIELFRRELQNYYE-----QVQTYD-------------TWGDIKQLSRYKKRAGVLDQRLVQA 721
            |::|:.|.::::.|..     :.|.:.             .||....:.|.|..|  :.|::...
Human  1177 KRKIKQFEKQVELYRNGQRLLEKQRFQFPPSWLYIDNIEGEWGAFNDIMRRKDSA--IQQQVANL 1239

  Fly   722 METIDQINEEETSYGWD-LSQYPMRKKAHDQLKPYK-----TLFDA--------------GQDFM 766
            ...|.|.:....|...| |:.:...|.....|:|.:     |:::.              .::.:
Human  1240 QMKIVQEDRAVESRTTDLLTDWEKTKPVTGNLRPEEALQALTIYEGKFGRLKDDREKCAKAKEAL 1304

  Fly   767 DKWDLWMHS------QVGSFDPDEIDGDVSNFYRIIQKLDKQMGDHP-ITMQ---LIQDVKA--- 818
            :..|..:.|      ||...:..::.|..|...::.:::| ||.:.| :::|   |.|::.|
Human  1305 ELTDTGLLSGSEERVQVALEELQDLKGVWSELSKVWEQID-QMKEQPWVSVQPRKLRQNLDALLN 1368

  Fly   819 QIEAF-----------------REHMPI---INTLGNPGMKARHWELVSEIIGFPIKVSPELTLE 863
            |:::|                 :.:|.|   :..|.:..:|.|||:.:.:.:.....|| ||||.
Human  1369 QLKSFPARLRQYASYEFVQRLLKGYMKINMLVIELKSEALKDRHWKQLMKRLHVNWVVS-ELTLG 1432

  Fly   864 KIIEYQLDEYVPKFEAISES----ATKENNLERAMAKMVNEWEGVEFSISPYRDSGTFKLAAVDD 924
            :|.:..|.    |.|||.:.    |..|..||..:.::...|...|..:..|::.... :...||
Human  1433 QIWDVDLQ----KNEAIVKDVLLVAQGEMALEEFLKQIREVWNTYELDLVNYQNKCRL-IRGWDD 1492

  Fly   925 IQILLDDQIIKTQTMKSSPYIKPFEADIIKWEAKLMLLQEILDEWLRVQATWMYLEPIFS-SPDI 988
            :...:.:.|.....||.|||.|.||.|.:.||.||..:..:.|.|:.||..|:|||.||: |.||
Human  1493 LFNKVKEHINSVSAMKLSPYYKVFEEDALSWEDKLNRIMALFDVWIDVQRRWVYLEGIFTGSADI 1557

  Fly   989 QQQMPEEGRRFSAVDKIWKELMKQVSQDPKVMVVVQIDKMNDKLKKAYSLLEVIQKGLNAYLEKK 1053
            :..:|.|.:||.::...:..|||:||:.|.||.|:.|..:...|::...||..|||.|..|||::
Human  1558 KHLLPVETQRFQSISTEFLALMKKVSKSPLVMDVLNIQGVQRSLERLADLLGKIQKALGEYLERE 1622

  Fly  1054 RLYFPRFFFLSNDELLEILSETKDPTRVQIHLKKCFEGIATLNFTEELDVT-AMRSSEREEVTLV 1117
            |..||||:|:.:::||||:..:|:..::|.|.||.|.|::::...|:..|. .:.|.|.|||...
Human  1623 RSSFPRFYFVGDEDLLEIIGNSKNVAKLQKHFKKMFAGVSSIILNEDNSVVLGISSREGEEVMFK 1687

  Fly  1118 DVISTSKARGQVEKWLLELEIDMKKSVHHKVSEAF--------------YSYLKMLRHVWVLTWP 1168
            ..:|.:: ..::.:||..:|.:|:.::...::|:.              .:|:     .|:..:.
Human  1688 TPVSITE-HPKINEWLTLVEKEMRVTLAKLLAESVTEVEIFGKATSIDPNTYI-----TWIDKYQ 1746

  Fly  1169 GQCVQSISLTYWTLEITECFES------EEPKENLAKYLQKCVLQINKIVDLVRGDLNTQNRITL 1227
            .|.|...:...|:..:.....|      ..|   |...|....:.:|.:.|.|..:.....|..|
Human  1747 AQLVVLSAQIAWSENVETALSSMGGGGDAAP---LHSVLSNVEVTLNVLADSVLMEQPPLRRRKL 1808

  Fly  1228 GALVVLDVHARDVLAEIVANQVEDLQDFQWLCQLRYYWEDNNLDT------RMINCSLPYGYEYL 1286
            ..|:...||.|||...::.:::::.:.|:||.|:|:|::....|.      :|.|....||:|||
Human  1809 EHLITELVHQRDVTRSLIKSKIDNAKSFEWLSQMRFYFDPKQTDVLQQLSIQMANAKFNYGFEYL 1873

  Fly  1287 GNTPRLVVTPLTDRCYRTLFAALNLHLGGAPEGPAGTGKTETTKDLAKAVAKQCVVFNCSDGLDY 1351
            |...:||.||||||||.|:..||...|||:|.|||||||||:.|.|...:.:..:||||.:..|:
Human  1874 GVQDKLVQTPLTDRCYLTMTQALEARLGGSPFGPAGTGKTESVKALGHQLGRFVLVFNCDETFDF 1938

  Fly  1352 LALGKFFKGLASCGAWSCFDEFNRIDLEVLSVVAQQILTIQRGINSGS-PTLVFEGTTLT----- 1410
            .|:|:.|.||...|||.|||||||::..:||.|:||:..||..:...| |........:|
Human  1939 QAMGRIFVGLCQVGAWGCFDEFNRLEERMLSAVSQQVQCIQEALREHSNPNYDKTSAPITCELLN 2003

  Fly  1411 ----LDPTCAVFITMNPGYAGRSELPDNLKALFRSVAMMVPDYALISEIELYSYGFLTAKPLSVK 1471
                :.|..|:||||||||||||.||||||.||||:||..||..||:::.|||.||.||:.|:.|
Human  2004 KQVKVSPDMAIFITMNPGYAGRSNLPDNLKKLFRSLAMTKPDRQLIAQVMLYSQGFRTAEVLANK 2068

  Fly  1472 IVATYRLCSEQLSTQCHYDYGMRAVKSVLKAAGALK-------LRYRDEN--------------E 1515
            ||..::||.||||:|.|||:|:||:||||.:||.:|       .|.::|.              |
Human  2069 IVPFFKLCDEQLSSQSHYDFGLRALKSVLVSAGNVKRERIQKIKREKEERGEAVDEGEIAENLPE 2133

  Fly  1516 DILVLRSIKDVNLPKFLNQDIPLFQGITSDLFPGTVLPEADYVLFNKCTQMACER------QNKQ 1574
            ..::::|:.:..:||.:.:||||...:.||:|||......:.....:..:..|:.      ..::
Human  2134 QEILIQSVCETMVPKLVAEDIPLLFSLLSDVFPGVQYHRGEMTALREELKKVCQEMYLTYGDGEE 2198

  Fly  1575 CTPFVLEKVQQLYEMIVVRHGLMLVGYPFGGKTTTYRVLAEALECMEKTDGSENKAIYTVINPKA 1639
            .....:|||.|||::..:.||||:||....||:..:|||.:|||.:|..:|     :..:|:|||
Human  2199 VGGMWVEKVLQLYQITQINHGLMMVGPSGSGKSMAWRVLLKALERLEGVEG-----VAHIIDPKA 2258

  Fly  1640 ITMGQLYGQFDAVSHEWSDGILAVNYRIFAISDS-----PDRKWLIFDGPVDAIWIENMNTVLDD 1699
            |:...|||..|..:.||:||:.  .:.:..|.||     ..|:|::|||.||..|:||:|:||||
Human  2259 ISKDHLYGTLDPNTREWTDGLF--THVLRKIIDSVRGELQKRQWIVFDGDVDPEWVENLNSVLDD 2321

  Fly  1700 NKKLCLMSGEIIQLSNTTNLVFEPMDLEVASPATVSRCGMIYLEPSSLGWEPLVASWKNTLPAAF 1764
            ||.|.|.:||.:.|.....::||..||:.|:.||||||||::.....|..:.:           |
Human  2322 NKLLTLPNGERLSLPPNVRIMFEVQDLKYATLATVSRCGMVWFSEDVLSTDMI-----------F 2375

  Fly  1765 HTVSKQLISMLISRFCPI------------------------LLFILRKSLKEIAP--TSDANLM 1803
            :....:|      |..|:                        :|.|.|.:...:.|  ||:..:.
Human  2376 NNFLARL------RSIPLDEGEDEAQRRRKGKEDEGEEAASPMLQIQRDAATIMQPYFTSNGLVT 2434

  Fly  1804 VSLMNFFECFIDDFRDE-----------------KYVA--NVSDLDFRAQTEGI-------FLFS 1842
            .:|.:.|:  ::...|.                 :.||  |.:..||..|.|.:       .:::
Human  2435 KALEHAFQ--LEHIMDLTRLRCLGSLFSMLHQACRNVAQYNANHPDFPMQIEQLERYIQRYLVYA 2497

  Fly  1843 CIWSLGGSLDADSREKFNIIFRALMEKTFPQSLYDTYGVPEDLYVESLAKPFIFPIPKQGSVFDY 1907
            .:|||.|    |||.|    .||.:.:                |:..:.   ..|:|...::...
Human  2498 ILWSLSG----DSRLK----MRAELGE----------------YIRRIT---TVPLPTAPNIPII 2535

  Fly  1908 RYIKEGKGKWKPWQDDVNSAPPIPRDIPVNQIIIQTNESVRIGAVLDLLNRHGKPIMLVGPTGTG 1972
            .|.....|:|.|||..|.........:....:::.|.::||..|:|.......||::|.||.|:|
Human  2536 DYEVSISGEWSPWQAKVPQIEVETHKVAAPDVVVPTLDTVRHEALLYTWLAEHKPLVLCGPPGSG 2600

  Fly  1973 KSVYVIDYMLKKMDLSFYKPLLISFSAQTSANQTQDIIMSKLDK----RR--KGVFGPP--LNSR 2029
            |::.:...:....|:   :.:.::||:.|    |.::::...|.    ||  .||...|  |...
Human  2601 KTMTLFSALRALPDM---EVVGLNFSSAT----TPELLLKTFDHYCEYRRTPNGVVLAPVQLGKW 2658

  Fly  2030 FVIFVDDVSMPLKENYGAQPPIELLRMMLDHMMWYDRKNIVPMKLIDLQMIVAMGPPST--GNTV 2092
            .|:|.|::::|..:.||.|..|..:|.|::|..:|...:...:||..:|.:.|..||:.  ...:
Human  2659 LVLFCDEINLPDMDKYGTQRVISFIRQMVEHGGFYRTSDQTWVKLERIQFVGACNPPTDPGRKPL 2723

  Fly  2093 TPRFQRFFNVISID------------DFNNDILNTIFSKIVLWHLDTRGFSKEFDPCIDEIVGAT 2145
            :.||.|...|:.:|            .||..:|..|.|        .|.::       :.:..|.
Human  2724 SHRFLRHVPVVYVDYPGPASLTQIYGTFNRAMLRLIPS--------LRTYA-------EPLTAAM 2773

  Fly  2146 LTIYNDAKLNLLPTPAKSHYLFNLRDFSRVIQGVLLSV-PEATEDVNSMRRLWVHEVLRVYGDRL 2209
            :..|..:: .......:.||:::.|:.:|.::|:..:: |..|..|..:.|:|.||.||::.|||
Human  2774 VEFYTMSQ-ERFTQDTQPHYIYSPREMTRWVRGIFEALRPLETLPVEGLIRIWAHEALRLFQDRL 2837

  Fly  2210 VEDADRSWLFENICSTVKSCFNTDPSRLFGRLVEKDKSLQESDFRQLIYCDFTNPKADTKNYVEV 2274
            |||.:|.|..|||.:.....|   |:      ::::|::.    |.::|.::.     :|:|:.|
Human  2838 VEDEERRWTDENIDTVALKHF---PN------IDREKAMS----RPILYSNWL-----SKDYIPV 2884

  Fly  2275 QDLEELRRVVEAYL-VEYNNMSKKPMNLVLFRFAIEHLSRICRIIKQPRSHALLIGVGGSGRQSL 2338
             |.||||..|:|.| |.|......|  ||||...::|:.||.||.:||:.|.|||||.|:|:.:|
Human  2885 -DQEELRDYVKARLKVFYEEELDVP--LVLFNEVLDHVLRIDRIFRQPQGHLLLIGVSGAGKTTL 2946

  Fly  2339 TRLASHICDYELFQVEITRLYGPYEYHEDIKAILRKIGASEMHGVFLFTDVQIKDESFLEDISNL 2403
            :|..:.:....::|:::.|.|...::.||::.:||:.|.......|:..:..:.|..|||.::.|
Human  2947 SRFVAWMNGLSVYQIKVHRKYTGEDFDEDLRTVLRRSGCKNEKIAFIMDESNVLDSGFLERMNTL 3011

  Fly  2404 LNSGEVPNLFTNEEKIEVQEKMAQIDKQRDKAVQTDG----SPVALFNFFVTTCKDQLHIVLAMS 2464
            |.:||||.||..:|       .|.:..|..:..|.:|    |...|:.:|.:.....||:|..|:
Human  3012 LANGEVPGLFEGDE-------YATLMTQCKEGAQKEGLMLDSHEELYKWFTSQVIRNLHVVFTMN 3069

  Fly  2465 PIGDALRNRIRKFPSIVNCCTIDWFQSWPEDALLAVSTRFLASEDL------------------- 2510
            |..:.|::|....|::.|.|.::||..|..:||..|...|.:..||
Human  3070 PSSEGLKDRAATSPALFNRCVLNWFGDWSTEALYQVGKEFTSKMDLEKPNYIVPDYMPVVYDKLP 3134

  Fly  2511 -TALERRTAIDMCMEFHTSTQELSAKFFSRLHRYNYVTPTSYLELIQTFKALLSQKRNNITNNRN 2574
             ....|...::.|:..|.:..:.:|:...|..|...:||..||:.|..:..|..:||:.:...:.
Human  3135 QPPSHREAIVNSCVFVHQTLHQANARLAKRGGRTMAITPRHYLDFINHYANLFHEKRSELEEQQM 3199

  Fly  2575 RYLTGISQLDIAAQQVAVMQEQLIALEPKLKEASEIVAEQVAKVTADSKLAEEQREI-VKLDESA 2638
            ....|:.::.....||..::..|.....:|:..:....:::.|:..|.:.||:::.: .::.|..
Human  3200 HLNVGLRKIKETVDQVEELRRDLRIKSQELEVKNAAANDKLKKMVKDQQEAEKKKVMSQEIQEQL 3264

  Fly  2639 AKEQAAVAQE---IKDECDAKLGEALPILESALAALNTLTTADIAVVKTMKSPPIGVRIVMEAVC 2700
            .|:|..:|.:   :|::.|    :..|.:..|..|:.::....:..|::|.:||..|::.:|::|
Human  3265 HKQQEVIADKQMSVKEDLD----KVEPAVIEAQNAVKSIKKQHLVEVRSMANPPAAVKLALESIC 3325

  Fly  2701 ILKDVKPDKVPNPSGLGTVEDYWGPSKRVLSDMKFLDSLLNFDKDNIPVEVMKKLAQRILSNEAF 2765
            :|             ||.....|...:.::....|:.:::||..:.|...:.:|:.:..:||.::
Human  3326 LL-------------LGESTTDWKQIRSIIMRENFIPTIVNFSAEEISDAIREKMKKNYMSNPSY 3377

  Fly  2766 DPDKIKSASTACEGLCRWVIALTKYDVVAKIVAPKKLALAEAEATYNAAMKTLNEKLAMLAKVEA 2830
            :.:.:..||.||..:.:|.||...|..:.|.|.|.:..|.:.|.......:..||...|:..:||
Human  3378 NYEIVNRASLACGPMVKWAIAQLNYADMLKRVEPLRNELQKLEDDAKDNQQKANEVEQMIRDLEA 3442

  Fly  2831 NLAAIQKILDEQLRQYGILLAEHE-------ACTKKLQRAQELISGLGGERTRWSETAKMLQASF 2888
            ::|..::       :|.:|::|.:       |...|:.|:..|:..|..||.||.:|::..:...
Human  3443 SIARYKE-------EYAVLISEAQAIKADLAAVEAKVNRSTALLKSLSAERERWEKTSETFKNQM 3500

  Fly  2889 KSVTGDVLISSGVVSYLGPFTIDFRVDQIRKWVTKCLNFGVTCTADFQLAVVLGEPVEIRFWNIC 2953
            .::.||.|:|:..::|.|.|....|.:....|........:....|......|....|...|...
Human  3501 STIAGDCLLSAAFIAYAGYFDQQMRQNLFTTWSHHLQQANIQFRTDIARTEYLSNADERLRWQAS 3565

  Fly  2954 GLPTDAFSIESAIMMKNARRWPLMIDPQGQANKWIKNYEKNNKLCVIRLNQADYTRVMENAIQFG 3018
            .||.|....|:|||:|...|:||:|||.|||.::|.|..|:.|:.........:.:.:|:|::||
Human  3566 SLPADDLCTENAIMLKRFNRYPLIIDPSGQATEFIMNEYKDRKITRTSFLDDAFRKNLESALRFG 3630

  Fly  3019 LPVLLENIGEELDPVLESVLQKTLFKQGGALCIKLGDSVIEYNHSFRFYMTTKLRNPHYLPEVAV 3083
            .|:|:::: |..||||..||.:.:.:.||.:.|.|||..|:.:.||..:::|:.....:.|::..
Human  3631 NPLLVQDV-ESYDPVLNPVLNREVRRTGGRVLITLGDQDIDLSPSFVIFLSTRDPTVEFPPDLCS 3694

  Fly  3084 KVTLLNFMITTQGLQDQLLGITVARERPDLEAEKNNLIVQGADNKRMLKETEDQILEVLSSAE-N 3147
            :||.:||.:|...||.|.|...:..||||::.::::|:....:.:..|::.|..:|:.|:..: .
Human  3695 RVTFVNFTVTRSSLQSQCLNEVLKAERPDVDEKRSDLLKLQGEFQLRLRQLEKSLLQALNEVKGR 3759

  Fly  3148 ILEDETAVQILSSAKALANDISEKQVITEATEKQIDIARLSYVPIAEHSTILFFTIVELANIDPM 3212
            ||:|:|.:..|.:.|..|.:::.|...|:...::::.....|:|::...:.::||:..|..|..:
Human  3760 ILDDDTIITTLENLKREAAEVTRKVEETDIVMQEVETVSQQYLPLSTACSSIYFTMESLKQIHFL 3824

  Fly  3213 YQYSLVWFVNLYMSSI---DNTEKVDDIAARLLDLRNHFTYSLYVNICRSLFERDKLLFSLIL-- 3272
            |||||.:|:::|.:.:   .|.:.|.|...||..:........:..:.|.:..:|.:.|:::|
Human  3825 YQYSLQFFLDIYHNVLYENPNLKGVTDHTQRLSIITKDLFQVAFNRVARGMLHQDHITFAMLLAR 3889

  Fly  3273 -----NINMMKHDNRIDNAEWMFLLTGGVGLENPYKNP-TTWLGVQNWDELCRLTNLTNFKGL-- 3329
                 .:....:|     ||:...|.|...:.:....| ...|.|:..:.:.||:.|..||.|
Human  3890 IKLKGTVGEPTYD-----AEFQHFLRGNEIVLSAGSTPRIQGLTVEQAEAVVRLSCLPAFKDLIA 3949

  Fly  3330 REDFNENSAQWKPFFDSKSPQDNKDIPKSWDNRV------SVFQKLLLLRVFRPDKLVPAVLNFV 3388
            :...:|....|   .||.||:  :.:|..|....      ....:|||::.||||:|:.....||
Human  3950 KVQADEQFGIW---LDSSSPE--QTVPYLWSEETPATPIGQAIHRLLLIQAFRPDRLLAMAHMFV 4009

  Fly  3389 SGELGERFVDPPQFDLMASFAD-SHCC-------VPLIFILTPGSDPTATLLKFAEDQGFGTNRL 3445
            |..|||.|:     .:|....| :|..       .|::....||.|.:..:...|.:|   ..::
Human  4010 STNLGESFM-----SIMEQPLDLTHIVGTEVKPNTPVLMCSVPGYDASGHVEDLAAEQ---NTQI 4066

  Fly  3446 FSLSLGQGQG-PIAMKMIDEGVKMGNWVVLQNCHLAASFMPLLEKICENLLPDATHPDFRLWLTS 3509
            .|:::|..:| ..|.|.|:..||.|.||:|:|.|||..::..|||...:|.|   |..|||:||.
Human  4067 TSIAIGSAEGFNQADKAINTAVKSGRWVMLKNVHLAPGWLMQLEKKLHSLQP---HACFRLFLTM 4128

  Fly  3510 YPADHFPVVVLQNGIKMTNEPPKGLRSNILRSMISDPISDPEWYESCTQPRIFKQLIYSLCFFHA 3574
            ......||.:|:.|.....|||.|:::|:||:..|.|:|     ..|..|....:|.:.|.:|||
Human  4129 EINPKVPVNLLRAGRIFVFEPPPGVKANMLRTFSSIPVS-----RICKSPNERARLYFLLAWFHA 4188

  Fly  3575 VIQERRYFGPIGWNIPYEFNETDLRISLMQLRMFLNQY---------ETVNYDALRYLTGECNYG 3630
            :||||..:.|:||:..|||.|:|||.:...:..:|:..         :.:.:.||:.|..:..||
Human  4189 IIQERLRYAPLGWSKKYEFGESDLRSACDTVDTWLDDTAKGRQNISPDKIPWSALKTLMAQSIYG 4253

  Fly  3631 GRVTDDWDRRTLKTILDKFYCPAVIDLETPYYLDETGLYYVPVFKEVDL--------YLNFTRDL 3687
            |||.:::|:|.|.|.|::.:.....|.|........|      .|::.:        ::.:...|
Human  4254 GRVDNEFDQRLLNTFLERLFTTRSFDSEFKLACKVDG------HKDIQMPDGIRREEFVQWVELL 4312

  Fly  3688 PQISAPAIFGFHANAD-IMKDQKETDMLLSHTLLTQKLEKKQRV-YVETLSRRFPENLS--LPTY 3748
            |....|:..|...||: ::...:..|| :|..|..|.||.:..: |.||..:...::.|  .|.:
Human  4313 PDTQTPSWLGLPNNAERVLLTTQGVDM-ISKMLKMQMLEDEDDLAYAETEKKTRTDSTSDGRPAW 4376

  Fly  3749 PTCPPFLALYQMSLKDTSASSDDSGGSKALTPEEV--VTNVATDILDKLPKLFDRDAALLKYPTL 3811
                       |....|:||:     ...|.|:.:  :.....:|.|.|.:.|:|:.
Human  4377 -----------MRTLHTTASN-----WLHLIPQTLSHLKRTVENIKDPLFRFFEREV-------- 4417

  Fly  3812 YHQSMNTVLVQEMVRFNVL------------LNTIRTSLITLRKGIKGLVVMSPAVEAVYKSVLI 3864
               .|...|:|: ||.::.            .|.:||.:..|.|||
Human  4418 ---KMGAKLLQD-VRQDLADVVQVCEGKKKQTNYLRTLINELVKGI------------------- 4459

  Fly  3865 AKIPAMWAGKSYPSLKPLGSYVTDFLRRLEFLQHWFDHGAPS---------TFWLSGFFFTQAFL 3920
              :|..|:..:.|:...:..:|:||..|::.||: ....|.|         ...|.|.|..:|::
Human  4460 --LPRSWSHYTVPAGMTVIQWVSDFSERIKQLQN-ISLAAASGGAKELKNIHVCLGGLFVPEAYI 4521

  Fly  3921 TGAQQNYARKYVISIDLLAFDYEVLTVEEPQRQGLSGPEDGVFVYGIFLEGARWDRTGKYLAESR 3985
            |..:|..|:....|::.|..:..|.|     .||.:.......|.|:.|:||..:.....|:.:
Human  4522 TATRQYVAQANSWSLEELCLEVNVTT-----SQGATLDACSFGVTGLKLQGATCNNNKLSLSNA- 4580

  Fly  3986 PRELFDTMPLIWLKPLKRVDLPERHNYL-CPMYKTAERRGVLSTTGHSTNFVVAMLLLCNPNTPV 4049
               :...:||..|:.:|:.:..::.:.: .|:|....|..::.|    .:|.:|     ....|.
Human  4581 ---ISTALPLTQLRWVKQTNTEKKASVVTLPVYLNFTRADLIFT----VDFEIA-----TKEDPR 4633

  Fly  4050 SHWIIRGTALLC 4061
            |.: .||.|:||
Human  4634 SFY-ERGVAVLC 4644

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dhc36C	NP_001369131.1	DHC_N2	746..1151	CDD:400618	128/462 (28%)
		DYN1	<984..3651	CDD:227570	821/2885 (28%)
		AAA_6	1281..1607	CDD:403853	154/362 (43%)
		AAA_8	2299..2561	CDD:403858	80/285 (28%)
		AAA_9	2950..3165	CDD:403859	70/215 (33%)
		Dynein_C	3779..4061	CDD:408026	63/305 (21%)
DYNC1H1	NP_001367.2	Stem. /evidence=ECO:0000250	53..1867		318/1552 (20%)
		DHC_N1	242..832	CDD:400611	89/483 (18%)
		Interaction with DYNC1I2. /evidence=ECO:0000250	448..703		58/316 (18%)
		Interaction with DYNC1LI2. /evidence=ECO:0000250	651..802		40/218 (18%)
		DYN1	1046..4329	CDD:227570	940/3461 (27%)
		AAA 1. /evidence=ECO:0000250	1868..2099		122/230 (53%)
		AAA 2. /evidence=ECO:0000250	2180..2452		88/297 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2390..2411		0/20 (0%)
		AAA 3. /evidence=ECO:0000250	2556..2805		60/271 (22%)
		AAA 4. /evidence=ECO:0000250	2899..3168		77/277 (28%)
		Stalk. /evidence=ECO:0000250	3189..3500		70/334 (21%)
		AAA 5. /evidence=ECO:0000250	3553..3782		73/229 (32%)
		AAA 6. /evidence=ECO:0000250	4005..4221		78/231 (34%)
		Dynein_C	4333..4644	CDD:408026	80/380 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5245
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100025
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.710