DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mEFTs and tsfm

DIOPT Version :9

Sequence 1:	NP_609847.1	Gene:	mEFTs / 35060	FlyBaseID:	FBgn0032646	Length:	318	Species:	Drosophila melanogaster
Sequence 2:	NP_001073504.1	Gene:	tsfm / 567785	ZFINID:	ZDB-GENE-061215-17	Length:	305	Species:	Danio rerio

Alignment Length:	284	Identity:	108/284 - (38%)
Similarity:	156/284 - (54%)	Gaps:	22/284 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 EKSALAALRKKTGYTFANCKKALEKHNNDVGLAEKWLHEQAQTLGWSKATKVADRATAHGLIGVL 92
            :|:.|..|||.|||||.||||||||.|||:..||.||||||:..|||||||:..|....||||::
Zfish    36 DKALLLQLRKSTGYTFVNCKKALEKCNNDITQAESWLHEQAKKEGWSKATKLEGRKAKEGLIGLM 100

  Fly    93 IRGNRGAMVELNCETDFVARNDTFKRFVDHVACMCLQYTDLTDFDGDLWKLGF-----DADALRN 152
            :..|...|||:||||||||||:.|::.|..||...:.:...:.      |.||     .::.:..
Zfish   101 MHDNAAVMVEVNCETDFVARNEKFQQLVKDVALSVMAHQSTSK------KTGFIKSVLSSEDMSK 159

  Fly   153 LRTEEGRTLGDHLALLIGAIGENATIRRALCFKANNDLKLVGYAHPAPTNVGTTEGIT--QVGKY 215
            |...:|.:|.|.|||.||.:|||..:|||:.....:|..:..|.|      ||..|..  ::|:|
Zfish   160 LNAPDGPSLADQLALTIGRLGENIAMRRAVSLSVPSDWHIGSYIH------GTVAGQVGIEMGRY 218

  Fly   216 GAIVAYRSTHPLLDFEFHKSICQQIVGMKPTKIGEYDKDKPAENKDDETCLIHQEYLLDADKTVG 280
            |::|.::.......:...:.:.|.::|..|..:|..|   .....|.||.|:.|.:|.|...||.
Zfish   219 GSLVVFQGEPKEGTYALGRKLAQHVMGEAPVSLGNMD---DLSCGDSETRLLPQTFLPDPKYTVA 280

  Fly   281 EALQEHNCEIVDYHRFECGEHTER 304
            :.|...:..::|:.||:|||.:.:
Zfish   281 QYLTLQDARVLDFIRFQCGESSSQ 304

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mEFTs	NP_609847.1	UBA_EF-Ts	32..66	CDD:270461	24/33 (73%)
		Tsf	35..303	CDD:223342	106/274 (39%)
		EF_TS	98..300	CDD:279261	64/208 (31%)
tsfm	NP_001073504.1	tsf	38..300	CDD:236491	105/276 (38%)
		UBA_EF-Ts	38..74	CDD:270461	24/35 (69%)
		EF_TS	106..300	CDD:279261	64/208 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592681
Domainoid	1	1.000	91	1.000	Domainoid score	I7732
eggNOG	1	0.900	-	-		E1_COG0264
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4184
Inparanoid	1	1.050	194	1.000	Inparanoid score	I3827
OMA	1	1.010	-	-		QHG54697
OrthoDB	1	1.010	-	-		D1048278at2759
OrthoFinder	1	1.000	-	-		FOG0003815
OrthoInspector	1	1.000	-	-		oto41708
orthoMCL	1	0.900	-	-		OOG6_101036
Panther	1	1.100	-	-	LDO	PTHR11741
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R369
SonicParanoid	1	1.000	-	-		X2659
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800