DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment qua and SCIN

DIOPT Version :9

Sequence 1:	NP_001246066.1	Gene:	qua / 35058	FlyBaseID:	FBgn0003187	Length:	892	Species:	Drosophila melanogaster
Sequence 2:	NP_001106177.1	Gene:	SCIN / 85477	HGNCID:	21695	Length:	715	Species:	Homo sapiens

Alignment Length:	802	Identity:	189/802 - (23%)
Similarity:	331/802 - (41%)	Gaps:	141/802 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 FRKVAKHAITFAIWKIDEDRLEAVQRSHYGTFYDSCAY-IIYAASLSGHYANHETITREQKPNVS 89
            |.:..|.| ...:|:|::..|..|.:|.:|.||...|| :::.|..|..:..|
Human    10 FARAGKQA-GLQVWRIEKLELVPVPQSAHGDFYVGDAYLVLHTAKTSRGFTYH------------ 61

  Fly    90 LERYIHYWLGKNVSEQNRSNVVHKIQELDSYLGNISSIYRETQNLESARFLSYFKKGYEFRF-SV 153
                :|:||||..|:...:.......::|.|||......||.|..||..|:||||.|.:::. .|
Human    62 ----LHFWLGKECSQDESTAAAIFTVQMDDYLGGKPVQNRELQGYESNDFVSYFKGGLKYKAGGV 122

  Fly   154 RSG---ALISAPQRPRLFQLYARKWLRSIEVATIDWSHFNSDYVMVLQTDNLTYVWIGRSSSGIE 215
            .||   .|.:.....||..:..|:.:|:.|| .:.|..||.....::......|.|.|.|.:..|
Human   123 ASGLNHVLTNDLTAKRLLHVKGRRVVRATEV-PLSWDSFNKGDCFIIDLGTEIYQWCGSSCNKYE 186

  Fly   216 RRSALDWVQKHCSG---------SPITIVDDGYEQAMSQEHKELWNTM-----LPLKKRMVCQAS 266
            |..|    .:..:|         |.:.:|::|      .|..||...:     ||       ...
Human   187 RLKA----NQVATGIRYNERKGRSELIVVEEG------SEPSELIKVLGEKPELP-------DGG 234

  Fly   267 QLVSEYADYNSNKF-RIYKCNQ-RGRLHLDQLDVGMPAKDDLSDAHGVYLLDN-YGQSIWLWVGG 328
            ......||.::.|. ::|..:. .|.:.:..:....|....:..:...::||: ..:.|::|.|.
Human   235 DDDDIIADISNRKMAKLYMVSDASGSMRVTVVAEENPFSMAMLLSEECFILDHGAAKQIFVWKGK 299

  Fly   329 QAPQADALSAMGNGRAFVKKKKYPDNTLVVRVLEGHEPVEFKRLFANWLNVWQENTRGHKPVSTK 393
            .|...:..:||.....|:::..|..||.:..:.||.|...||:.|.:|.:..|.:..|...|:.|
Human   300 DANPQERKAAMKTAEEFLQQMNYSKNTQIQVLPEGGETPIFKQFFKDWRDKDQSDGFGKVYVTEK 364

  Fly   394 FGKL-----DAHSLCERPKMAADTQLVDDGRGERVIYRVFGDQVQEVPISKTVVFTTNASFVVKY 453
            ..::     ||..|...|:|||...:||||.|:..|:||..:...:|..:....|.....:::.|
Human   365 VAQIKQIPFDASKLHSSPQMAAQHNMVDDGSGKVEIWRVENNGRIQVDQNSYGEFYGGDCYIILY 429

  Fly   454 SVQCATVVPADLASVGIKTIIYQWNGSEASVESISRADKFAKASFD-GLKEPGMFVQLYEFDEPP 517
            :....             .|||.|.|:.|:.:.:: ...|.....| .|....:.:::.:..||.
Human   430 TYPRG-------------QIIYTWQGANATRDELT-TSAFLTVQLDRSLGGQAVQIRVSQGKEPV 480

  Fly   518 HFLQIFEGKLII-------RRGQRTEMPYNGNSNALLDTFLLKVYGDASYNAKAVE-ETHLSSIS 574
            |.|.:|:.|.:|       ::|.:...|         .|.|.:|..:.:...:.|| :...:|::
Human   481 HLLSLFKDKPLIIYKNGTSKKGGQAPAP---------PTRLFQVRRNLASITRIVEVDVDANSLN 536

  Fly   575 SKDCYVIK--TNHVWVWCGQSSTGDAREMAKAVGALMGENSL-VLEGKESKEFWQSVAMYFNQTL 636
            |.|.:|:|  .|..::|.|:.::.:..:.|:.|.:::...:| :.||:|.:|||.|:
Human   537 SNDVFVLKLPQNSGYIWVGKGASQEEEKGAEYVASVLKCKTLRIQEGEEPEEFWNSL-------- 593

  Fly   637 VINGNGNSCSSSTSSSSGAGSMCNGSSNGGNISPTLSNNCYLNTSVPSKPRPPVQLFLVWWQQSS 701
                                    |.......||.|...        ::..|| :|:....:...
Human   594 ------------------------GGKKDYQTSPLLETQ--------AEDHPP-RLYGCSNKTGR 625

  Fly   702 LRYEEILG-FDQQDLSSDCTYILDTGSLTYVWLGSQAPNQERYTAI--AQSYVQNAPFGRRSATA 763
            ...|||.| |.|.||:.|...:||.....::|:|..|...|:..::  |:.|::..|.||...|.
Human   626 FVIEEIPGEFTQDDLAEDDVMLLDAWEQIFIWIGKDANEVEKKESLKSAKMYLETDPSGRDKRTP 690

  Fly   764 LAVVRQFQEPNVFKGFFESWQN 785
            :.:::|..||..|.|:|..|.:
Human   691 IVIIKQGHEPPTFTGWFLGWDS 712

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
qua	NP_001246066.1	ADF_gelsolin	26..147	CDD:301701	36/121 (30%)
		gelsolin_like	164..254	CDD:200436	23/98 (23%)
		gelsolin_S3_like	276..375	CDD:200448	22/101 (22%)
		GEL	424..526	CDD:214590	20/102 (20%)
		ADF_gelsolin	551..625	CDD:301701	19/77 (25%)
		gelsolin_like	689..780	CDD:200436	28/93 (30%)
		VHP	857..892	CDD:128458
SCIN	NP_001106177.1	Actin-severing. /evidence=ECO:0000255	1..363		94/387 (24%)
		gelsolin_S1_like	10..121	CDD:200446	37/127 (29%)
		Polyphosphoinositide binding. /evidence=ECO:0000250	112..119		2/6 (33%)
		gelsolin_S2_like	136..225	CDD:200445	23/99 (23%)
		Polyphosphoinositide binding. /evidence=ECO:0000250	138..146		2/7 (29%)
		gelsolin_S3_like	246..346	CDD:200448	22/99 (22%)
		Ca(2+)-dependent actin binding	364..715		95/413 (23%)
		gelsolin_S4_like	390..486	CDD:200449	24/109 (22%)
		gelsolin_S5_like	508..598	CDD:200444	25/130 (19%)
		gelsolin_S6_like	613..711	CDD:200447	30/98 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1376537at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100298
Panther	1	1.100	-	-	O	PTHR11977
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.820