DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment qua and VLN5

DIOPT Version :9

Sequence 1:	NP_001246066.1	Gene:	qua / 35058	FlyBaseID:	FBgn0003187	Length:	892	Species:	Drosophila melanogaster
Sequence 2:	NP_001318818.1	Gene:	VLN5 / 835837	AraportID:	AT5G57320	Length:	962	Species:	Arabidopsis thaliana

Alignment Length:	1036	Identity:	221/1036 - (21%)
Similarity:	379/1036 - (36%)	Gaps:	277/1036 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 IWKIDEDRLEAVQRSHYGTFYDSCAYIIY--AASLSGHYANHETITREQKPNVSLERYIHYWLGK 100
            ||:|:..:...|.:..:|.|:...:||:.  .||.||                ||...|||||||
plant    23 IWRIENFKPVTVPQESHGKFFTGDSYIVLKTTASRSG----------------SLHHDIHYWLGK 71

  Fly   101 NVSEQNRSNVVHKIQELDSYLGNISSIYRETQNLESARFLSYFK------KGYEFRFSVRSGALI 159
            :.|:.....|.....||||.||..:..|||.|..|:.:||||||      :|     .|.||...
plant    72 DSSQDEAGAVAVMTVELDSALGGRAVQYREVQGHETEKFLSYFKPCIIPQEG-----GVASGFNH 131

  Fly   160 SAPQRPRLFQLYARKWLRSIEVATIDW--SHFNSDYVMVLQTDNLTYVWIGRSSSGIERRSALDW 222
            ..|:..:. :||..|....:.|..:.:  |..|.:.|.:|.|::..:.:.|..||..||..||:.
plant   132 VKPEEHQT-RLYICKGKHVVRVKEVPFVRSTLNHEDVFILDTESKIFQFSGSKSSIQERAKALEV 195

  Fly   223 VQ-----KHCSGSPITIVDDGYEQAMSQEHKELWNT---MLPLKKRMVCQASQLVSEYADYNSNK 279
            ||     .|.....|..|:||...| ..|..|.|..   ..||.|:......:..:      |:.
plant   196 VQYIKDTYHDGKCDIAAVEDGRMMA-DAEAGEFWGLFGGFAPLPKKPAVNDDETAA------SDG 253

  Fly   280 FRIYKCNQRGRLHLDQLDVGMPAKDDLSDAHGVYLLDNYGQSIWLWVGGQAPQADALSAMGNGRA 344
            .:::.. ::|:  .|.::.....| :|.|.:..|:|| .|..:::|.|.........||......
plant   254 IKLFSV-EKGQ--TDAVEAECLTK-ELLDTNKCYILD-CGLELFVWKGRSTSIDQRKSATEAAEE 313

  Fly   345 FVKKKKYPDNTLVVRVLEGHEPVEFKRLFANW--LNVWQENTRGHKPVSTKFG----------KL 397
            |.:..:.|.:.| |.|:||:|.|.|:..|.:|  .:...|..:|...|:....          |.
plant   314 FFRSSEPPKSNL-VSVMEGYETVMFRSKFDSWPASSTIAEPQQGRGKVAALLQRQGVNVQGLVKT 377

  Fly   398 DAHSLCERPKMAADTQLVDDGRGERVIYRVFGDQVQEVPISKTVVFTTNASFVVKYSVQCATVVP 462
            .:.|..:.||...      ||.|...::|:..::...:..::...|.:...::::||      .|
plant   378 SSSSSKDEPKPYI------DGTGNLQVWRINCEEKILLEAAEQSKFYSGDCYILQYS------YP 430

  Fly   463 ADLASVGIKTIIYQWNGSEASVESISRADKFAKASFDGLKEPGMFVQLYEFDEPPHFLQIFEGKL 527
            .:...   :.::..|.|.::..|..:.|...|....:.:|......::.|..||..|..|.:..:
plant   431 GEDRE---EHLVGTWFGKQSVEEDRASAISLANKMVESMKFVPAQARINEGKEPIQFFVIMQSFI 492

  Fly   528 IIRRGQRTEMPYNGNSNALLDT-------FLLKVYGDASYNAKAVE-ETHLSSISSKDCYVIK-T 583
            ..:.|...........|.:.||       .|.:|.|....|.:|:: |...:.::|..||::. .
plant   493 TFKGGVSDAFKKYIAENDIPDTTYEAEGVALFRVQGSGPENMQAIQIEAASAGLNSSHCYILHGD 557

  Fly   584 NHVWVWCGQSSTGDAREMAKAVGALMGEN---SLVLEGKESKEFWQSVAMYFNQTLVINGNGNSC 645
            :.|:.|||..::.:.:|:.:.:..|:..|   ....||.||::||:          ::.|.....
plant   558 STVFTWCGNLTSSEDQELMERMLDLIKPNEPTKAQKEGSESEQFWE----------LLGGKSEYP 612

  Fly   646 SSSTSSSSGAGSMCNGSSNGGNISPTLSNNCYLNTSVPSKPRPPVQLFLVWWQQSSLRYEEILGF 710
            |...             ...|...|.|.:..|.|                    .||:..||..|
plant   613 SQKI-------------KRDGESDPHLFSCTYTN--------------------ESLKATEIFNF 644

  Fly   711 DQQDLSSDCTYILDTGSLTYVWLGSQAPNQERYTA--IAQSYVQNAPF---GRRSATALAVVRQF 770
            .|.||.::..:|||..:..:||:|.|...:::..|  |.:::::: .|   ...|.|.:.:|.:.
plant   645 TQDDLMTEDIFILDCHTEVFVWVGQQVDPKKKPQALDIGENFLKH-DFLLENLASETPIYIVTEG 708

  Fly   771 QEPNVFKGFFESWQND----YGKNFH--------------------------------------- 792
            .||..|..|| :|.:.    :|.:|.
plant   709 NEPPFFTRFF-TWDSSKSGMHGDSFQRKLAILTNKGKPLLDKPKRRVPAYSSRSTVPDKSQPRSR 772

  Fly   793 -----------------------SYEKM----------------RK--------DLGNKVTSNCC 810
                                   ::||:                ||        || :|:.....
plant   773 SMTFSPDRARVRGRSPAFNALAANFEKLNIRNQSTPPPMVSPMVRKLYPKSHAPDL-SKIAPKSA 836

  Fly   811 FAS---------------------------------------EGSALILNNRQKDFDGHKK---- 832
            .|:                                       |.:...:|...|:.:..::
plant   837 IAARTALFEKPTPTSQEPPTSPSSSEATNQAEAPKSTSETNEEEAMSSINEDSKEEEAEEESSLP 901

  Fly   833 -YPLTVLIQEMDMLPPDINPLKREVHLTHDDFVSVFNMSFYEFDELPKWKKMELKKQFKLF 892
             :|...|..:.:....|::..:||.:||..:|...|.|:..||.:|||||:.:||....||
plant   902 TFPYERLKTDSEDPVSDVDLTRREAYLTSVEFKEKFEMTKNEFYKLPKWKQNKLKMSVNLF 962

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
qua	NP_001246066.1	ADF_gelsolin	26..147	CDD:301701	40/116 (34%)
		gelsolin_like	164..254	CDD:200436	27/99 (27%)
		gelsolin_S3_like	276..375	CDD:200448	25/98 (26%)
		GEL	424..526	CDD:214590	16/101 (16%)
		ADF_gelsolin	551..625	CDD:301701	20/78 (26%)
		gelsolin_like	689..780	CDD:200436	24/95 (25%)
		VHP	857..892	CDD:128458	14/34 (41%)
VLN5	NP_001318818.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0443
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1376537at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100298
Panther	1	1.100	-	-	O	PTHR11977
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.780