DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment qua and VLN3

DIOPT Version :9

Sequence 1:	NP_001246066.1	Gene:	qua / 35058	FlyBaseID:	FBgn0003187	Length:	892	Species:	Drosophila melanogaster
Sequence 2:	NP_001319779.1	Gene:	VLN3 / 824908	AraportID:	AT3G57410	Length:	965	Species:	Arabidopsis thaliana

Alignment Length:	1066	Identity:	240/1066 - (22%)
Similarity:	387/1066 - (36%)	Gaps:	303/1066 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 VDATFRKVAKHAITFAIWKIDEDRLEAVQRSHYGTFYDSCAYIIYAASLSGHYANHETITREQKP 86
            :|..|:.|.:...| .||:|:......|.:|.:|.||....||:..             |.:.|.
plant     8 LDPAFQGVGQKPGT-EIWRIENFEPVPVPKSEHGKFYMGDTYIVLQ-------------TTQNKG 58

  Fly    87 NVSLERYIHYWLGKNVSEQNRSNVVHKIQELDSYLGNISSIYRETQNLESARFLSYFK------K 145
            ...|.. ||:|:||:.|:........|..|||:.||..:..|||.|..||.:||||||      :
plant    59 GAYLFD-IHFWIGKDTSQDEAGTAAVKTVELDAALGGRAVQYREIQGHESDKFLSYFKPCIIPLE 122

  Fly   146 GYEFRFSVRSGALISAPQRPRL-FQLYARKWLRSIEVATIDW--SHFNSDYVMVLQTDNLTYVWI 207
            |     .|.||  ...|:.... .:||..|..|::.:..:.:  |..|.|.|.:|.|....|.:.
plant   123 G-----GVASG--FKKPEEEEFETRLYTCKGKRAVHLKQVPFARSSLNHDDVFILDTKEKIYQFN 180

  Fly   208 GRSSSGIERRSALDWVQK-----HCSGSPITIVDDGY--EQAMSQEHKELWNTMLPLKKRMVCQA 265
            |.:|:..||..||..:|.     |...|.:.|||||.  .::.|.|...|:....|: .|.|...
plant   181 GANSNIQERAKALVVIQYLKDKFHEGTSDVAIVDDGKLDTESDSGEFWVLFGGFAPI-ARKVASE 244

  Fly   266 SQLVSEYADYNSNKFRIYKCNQRGRLHLDQLDVGMPAKDDLS----DAHGVYLLDNYGQSIWLWV 326
            .:::.|     :...::|.....   .::.:|      .|||    :.:..|||| .|..|::||
plant   245 DEIIPE-----TTPPKLYSIADG---QVESID------GDLSKSMLENNKCYLLD-CGSEIFIWV 294

  Fly   327 GGQAPQADALSAMGNGRAFVKKKKYPDNTLVVRVLEGHEPVEFKRLFANW----LNVWQENTRGH 387
            |......:..:|:.....||..:..|..|.:.||::|:||..||..|.:|    .....|..||.
plant   295 GRVTQVEERKTAIQAAEDFVASENRPKATRITRVIQGYEPHSFKSNFDSWPSGSATPANEEGRGK 359

  Fly   388 KPVSTKFGKLDAHSLCERPKMAADTQLVDDGRGERVIYRVFGDQVQEVPISKTVVFTTNASFVVK 452
            .....|...:....|.:...:..|...:.:|.|:..::.:..:       ||||:...:...:
plant   360 VAALLKQQGVGLKGLSKSTPVNEDIPPLLEGGGKLEVWYIDAN-------SKTVLSKDHVGKL-- 415

  Fly   453 YSVQCATVVPADLASVGIKTIIYQ------------WNGSEASVESISRADKFAKASFDGLKEPG 505
            ||..|..|:           ..|.            |.|..::.|....|.:.|....:.||...
plant   416 YSGDCYLVL-----------YTYHSGERKEDYFLCCWFGKNSNQEDQETAVRLASTMTNSLKGRP 469

  Fly   506 MFVQLYEFDEPPHFLQIFEGKLIIR----RGQRTEMPYNGNSNALLDTF------LLKVYGDASY 560
            :..:::|..|||.|:.:|:..::::    .|.:..|...|:|.   :|:      |::|.|...:
plant   470 VQARIFEGKEPPQFVALFQHMVVLKGGLSSGYKNSMTEKGSSG---ETYTPESIALIQVSGTGVH 531

  Fly   561 NAKAVE-ETHLSSISSKDCYVIKT-NHVWVWCGQSSTGDAREMAKAVGALMGENSLV---LEGKE 620
            |.||:: |...:|::|.||::::: ..:::|.|..||.:.:|:|..|...:...:.:   .||.|
plant   532 NNKALQVEAVATSLNSYDCFLLQSGTSMFLWVGNHSTHEQQELAAKVAEFLKPGTTIKHAKEGTE 596

  Fly   621 SKEFWQSVAMYFNQTLVINGNGNSCSSSTSSSSGAGSMCNGSSNGGNISPTLSNNCYLNTSVPSK 685
            |..||          ..:.|..|..|...||.:
plant   597 SSSFW----------FALGGKQNFTSKKVSSET-------------------------------- 619

  Fly   686 PRPPVQLFLVWWQQSSLRYEEILGFDQQDLSSDCTYILDTGSLTYVWLGSQAPNQERYTA--IAQ 748
            .|.| .||...:.:...:.|||..|||.||.::..::|||.:..:||:|.....:|:.||  |.|
plant   620 VRDP-HLFSFSFNRGKFQVEEIHNFDQDDLLTEEMHLLDTHAEVFVWVGQCVDPKEKQTAFEIGQ 683

  Fly   749 SYVQNAPF--GRRSATALAVVRQFQEPNVFKGFFESWQ--------NDYGK------NFHSYEKM 797
            .|:..|..  |......|..:.:..||..|..:| ||.        |.|.|      ..|...:.
plant   684 RYINLAGSLEGLSPKVPLYKITEGNEPCFFTTYF-SWDSTKATVQGNSYQKKAALLLGTHHVVED 747

  Fly   798 RKDLGNK-----------VTSNCCFASEGSALILNNRQKDFDGHKKYP------LTVLIQEMDML 845
            :...||:           :||  .|.|........:|.:. :|.:..|      |..|....:..
plant   748 QSSSGNQGPRQRAAALAALTS--AFNSSSGRTSSPSRDRS-NGSQGGPRQRAEALAALTSAFNSS 809

  Fly   846 P------------------------------------PDINP----------------------- 851
            |                                    ||.:|
plant   810 PSSKSPPRRSGLTSQASQRAAAVAALSQVLTAEKKKSPDTSPSAEAKDEKAFSEVEATEEATEAK 874

  Fly   852 --------------------------------------------------LKREVHLTHDDFVSV 866
                                                              .:||.:|:..:|.:|
plant   875 EEEEVSPAAEASAEEAKPKQDDSEVETTGVTFTYERLQAKSEKPVTGIDFKRREAYLSEVEFKTV 939

  Fly   867 FNMSFYEFDELPKWKKMELKKQFKLF 892
            |.|....|.:||.||:..|||:|.||
plant   940 FGMEKESFYKLPGWKQDLLKKKFNLF 965

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
qua	NP_001246066.1	ADF_gelsolin	26..147	CDD:301701	40/126 (32%)
		gelsolin_like	164..254	CDD:200436	28/99 (28%)
		gelsolin_S3_like	276..375	CDD:200448	27/102 (26%)
		GEL	424..526	CDD:214590	22/113 (19%)
		ADF_gelsolin	551..625	CDD:301701	22/78 (28%)
		gelsolin_like	689..780	CDD:200436	29/94 (31%)
		VHP	857..892	CDD:128458	14/34 (41%)
VLN3	NP_001319779.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0443
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1376537at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100298
Panther	1	1.100	-	-	O	PTHR11977
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.780