DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment qua and CAPG

DIOPT Version :9

Sequence 1:NP_001246066.1 Gene:qua / 35058 FlyBaseID:FBgn0003187 Length:892 Species:Drosophila melanogaster
Sequence 2:NP_001243068.1 Gene:CAPG / 822 HGNCID:1474 Length:348 Species:Homo sapiens


Alignment Length:359 Identity:84/359 - (23%)
Similarity:159/359 - (44%) Gaps:54/359 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    38 IWKIDEDRLEAVQRSHYGTFYDSCAYIIYAASLSGHYANHETITREQKPNVSLERYIHYWLGKNV 102
            :|::::.:...|.:.:.|.|:...:|::.      |....|.            .::|.|:|:..
Human    23 VWRVEKLKPVPVAQENQGVFFSGDSYLVL------HNGPEEV------------SHLHLWIGQQS 69

  Fly   103 SEQNRSNVVHKIQELDSYLGNISSIYRETQNLESARFLSYFKKGYEFRFSVRSGALISAPQR--- 164
            |...:.........|::.||.....:||.|..||..|:|||.:|.::    :.|.:.||..:   
Human    70 SRDEQGACAVLAVHLNTLLGERPVQHREVQGNESDLFMSYFPRGLKY----QEGG
VESAFHKTST 130

  Fly   165 ------PRLFQLYARKWLRSIEVATIDWSHFNSDYVMVLQTDNLTYVWIGRSSSGIERRSALDWV 223
                  .:|:|:..:|.:|:.|.| ::|..||:....:|......:.|.|..|:.:||..|.|..
Human   131 GAPAAIKKLYQVKGKKNIRATERA-LNWDSFNTGDCFILDLGQNIFAWCGGKSNILERNKARDLA 194

  Fly   224 -----QKHCSGSPITIVDDGYEQAMSQEHKELWNTMLP---LKKRMVCQASQLVSEYADYNSNKF 280
                 .:....:.:.||.||.|.|      |:...:.|   ||:..  ....|.::.|  |:...
Human   195 LAIRDSERQGKAQVEIVTDGEEPA------EMIQVLGPKPALKEGN--PEEDLTADKA--NAQAA 249

  Fly   281 RIYKCNQ-RGRLHLDQLDVGMPAKDDLSDAHGVYLLDN--YGQSIWLWVGGQAPQADALSAMGNG 342
            .:||.:. .|:::|.::....|...:|..:...::|||  .|: |::|.|.:|.:.:..:|:...
Human   250 ALYKVSDATGQMNLTKVADSSPFALELLISDDCFVLDNGLCGK-IYIWKGRKANEKERQAALQVA 313

  Fly   343 RAFVKKKKYPDNTLVVRVLEGHEPVEFKRLFANW 376
            ..|:.:.:|..||.|..:.:|||...||:.|.:|
Human   314 EGFISRMQYAPNTQVEILPQGHESPIFKQFFKDW 347

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
quaNP_001246066.1 ADF_gelsolin 26..147 CDD:301701 23/108 (21%)
gelsolin_like 164..254 CDD:200436 24/103 (23%)
gelsolin_S3_like 276..375 CDD:200448 27/101 (27%)
GEL 424..526 CDD:214590
ADF_gelsolin 551..625 CDD:301701
gelsolin_like 689..780 CDD:200436
VHP 857..892 CDD:128458
CAPGNP_001243068.1 gelsolin_S1_like 17..120 CDD:200446 24/118 (20%)
Gelsolin-like 1 27..75 10/65 (15%)
gelsolin_S2_like 137..225 CDD:200445 24/94 (26%)
Nuclear localization signal. /evidence=ECO:0000255 137..146 2/8 (25%)
Gelsolin-like 2 148..188 11/40 (28%)
gelsolin_S3_like 251..346 CDD:200448 26/95 (27%)
Gelsolin-like 3 261..307 11/46 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0443
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1376537at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11977
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.920

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