DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment qua and VLN2

DIOPT Version :9

Sequence 1:	NP_001246066.1	Gene:	qua / 35058	FlyBaseID:	FBgn0003187	Length:	892	Species:	Drosophila melanogaster
Sequence 2:	NP_001323674.1	Gene:	VLN2 / 818773	AraportID:	AT2G41740	Length:	976	Species:	Arabidopsis thaliana

Alignment Length:	1064	Identity:	235/1064 - (22%)
Similarity:	384/1064 - (36%)	Gaps:	317/1064 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 IWKIDEDRLEAVQRSHYGTFYDSCAYIIYAASLSGHYANHETITREQKPNVSLERYIHYWLGKNV 102
            ||:|:......|.:|.:|.||....||:..             |.:.|....|.. ||:|:||:.
plant    21 IWRIENFEAVPVPKSEHGKFYMGDTYIVLQ-------------TTQNKGGAYLFD-IHFWIGKDT 71

  Fly   103 SEQNRSNVVHKIQELDSYLGNISSIYRETQNLESARFLSYFK------KGYEFRFSVRSGALISA 161
            |:........|..|||:.||..:..:||.|..||.:||||||      :|     .|.||   ..
plant    72 SQDEAGTAAVKTVELDAVLGGRAVQHREIQGHESDKFLSYFKPCIIPLEG-----GVASG---FK 128

  Fly   162 PQRPRLFQ--LYARKWLRSIEVATIDW--SHFNSDYVMVLQTDNLTYVWIGRSSSGIERRSALDW 222
            .....:|:  ||..|..|:|.:..:.:  |..|.|.|.:|.|:...|.:.|.:|:..||..||:.
plant   129 TVEEEVFETRLYTCKGKRAIRLKQVPFARSSLNHDDVFILDTEEKIYQFNGANSNIQERAKALEV 193

  Fly   223 VQ----KHCSGS-PITIVDDGY--EQAMSQEHKELWNTMLPLKKRMVCQASQLVSEYADYNSNKF 280
            ||    |:..|: .:.|||||.  .::.|.....|:....|: .|.|.....:|.|     |...
plant   194 VQYLKDKYHEGTCDVAIVDDGKLDTESDSGAFWVLFGGFAPI-GRKVANDDDIVPE-----STPP 252

  Fly   281 RIYKCNQRGRLHLDQLDVGMPAKDDLS----DAHGVYLLDNYGQSIWLWVGGQAPQADALSAMGN 341
            ::| |...|::.        |...|||    :....|||| .|..|::|||......:..:|..:
plant   253 KLY-CITDGKME--------PIDGDLSKSMLENTKCYLLD-CGAEIYIWVGRVTQVDERKAASQS 307

  Fly   342 GRAFVKKKKYPDNTLVVRVLEGHEPVEFKRLFANW----LNVWQENTRGHKPVSTKFGKLDAHSL 402
            ...|:..:..|..|.|.||::|:|...||..|.:|    .....|..||......|...:....:
plant   308 AEEFLASENRPKATHVTRVIQGYESHSFKSNFDSWPSGSATPGNEEGRGKVAALLKQQGVGLKGI 372

  Fly   403 CERPKMAADTQLVDDGRGERVIYRVFGDQVQEVP---ISKTVVFTTNASFVV----------KYS 454
            .:...:..|...:.:..|:..::.|.|.....:|   |.|  :::.:...|:          :|.
plant   373 AKSAPVNEDIPPLLESGGKLEVWYVNGKVKTPLPKEDIGK--LYSGDCYLVLYTYHSGERKDEYF 435

  Fly   455 VQCATVVPADLASVGIKTIIYQWNGSEASVESISRADKFAKASFDGLKEPGMFVQLYEFDEPPHF 519
            :.|                   |.|.::..|....|.:.|....:.||...:..::||..|||.|
plant   436 LSC-------------------WFGKKSIPEDQDTAIRLANTMSNSLKGRPVQGRIYEGKEPPQF 481

  Fly   520 LQIFEGKLIIR----RGQRTEMPYNGNSNALLDTF------LLKVYGDASYNAKAVE-ETHLSSI 573
            :.:|:..::::    .|.::.|   |.|.:..:|:      |::|.|...:|.|||: ||..:|:
plant   482 VALFQPMVVLKGGLSSGYKSSM---GESESTDETYTPESIALVQVSGTGVHNNKAVQVETVATSL 543

  Fly   574 SSKDCYVIKT-NHVWVWCGQSSTGDAREMAKAVGALMGENSLVL----EGKESKEFWQSVAMYFN 633
            :|.:|::::: ..:::|.|..||.:..|:|..|...: :..:.|    ||.||..||
plant   544 NSYECFLLQSGTSMFLWHGNQSTHEQLELATKVAEFL-KPGITLKHAKEGTESSTFW-------- 599

  Fly   634 QTLVINGNGNSCSSSTSSSSGAGSMCNGSSNGGNISPTLSNNCYLNTSVPSKPRPPVQLFLVWWQ 698
              ..:.|..|..|...||.:                                .|.| .||...:.
plant   600 --FALGGKQNFTSKKASSET--------------------------------IRDP-HLFSFAFN 629

  Fly   699 QSSLRYEEILGFDQQDLSSDCTYILDTGSLTYVWLGSQAPNQERYTA--IAQSYVQNAPF--GRR 759
            :...:.|||..|.|.||.::..|.|||.:..:||:|.....:|:.|.  |.|.|:..|..  |..
plant   630 RGKFQVEEIYNFAQDDLLTEDIYFLDTHAEVFVWVGQCVEPKEKQTVFEIGQKYIDLAGSLEGLH 694

  Fly   760 SATALAVVRQFQEPNVFKGFFESWQ--------NDYGK------NFHSYEKMRKDLGNK------ 804
            ....:..:.:..||..|..:| ||.        |.:.|      ..|...:.:.:.||:
plant   695 PKVPIYKINEGNEPCFFTTYF-SWDATKAIVQGNSFQKKASLLFGTHHVVEDKSNGGNQGLRQRA 758

  Fly   805 ---VTSNCCFASEGSALILNNRQKDFDGH------------------------KKYP-------- 834
               ...|..|.|..:....:::.:..:.|                        |..|
plant   759 EALAALNSAFNSSSNRPAYSSQDRLNESHDGPRQRAEALAALSSAFNSSSSSTKSPPPPRPVGTS 823

  Fly   835 ------------LTVLIQEMDMLPPDINPL----------------------------------- 852
                        ..||:.| :...||.:|.
plant   824 QASQRAAAVAALSQVLVAE-NKKSPDTSPTRRSTSSNPADDIPLTEAKDEEEASEVAGLEAKEEE 887

  Fly   853 -------------------------------------------------KREVHLTHDDFVSVFN 868
                                                             :||.:|:.::|.|||.
plant   888 EVSPAADETEAKQETEEQGDSEIQPSGATFTYEQLRAKSENPVTGIDFKRREAYLSEEEFQSVFG 952

  Fly   869 MSFYEFDELPKWKKMELKKQFKLF 892
            :....|:.||:||:..|||:|.||
plant   953 IEKEAFNNLPRWKQDLLKKKFDLF 976

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
qua	NP_001246066.1	ADF_gelsolin	26..147	CDD:301701	36/114 (32%)
		gelsolin_like	164..254	CDD:200436	30/100 (30%)
		gelsolin_S3_like	276..375	CDD:200448	29/102 (28%)
		GEL	424..526	CDD:214590	22/114 (19%)
		ADF_gelsolin	551..625	CDD:301701	24/79 (30%)
		gelsolin_like	689..780	CDD:200436	27/94 (29%)
		VHP	857..892	CDD:128458	14/34 (41%)
VLN2	NP_001323674.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0443
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1376537at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100298
Panther	1	1.100	-	-	O	PTHR11977
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.780