DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment qua and scin

DIOPT Version :9

Sequence 1:	NP_001246066.1	Gene:	qua / 35058	FlyBaseID:	FBgn0003187	Length:	892	Species:	Drosophila melanogaster
Sequence 2:	NP_001038583.1	Gene:	scin / 566764	ZFINID:	ZDB-GENE-060503-6	Length:	733	Species:	Danio rerio

Alignment Length:	815	Identity:	211/815 - (25%)
Similarity:	347/815 - (42%)	Gaps:	166/815 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 FRKVAKHAITFAIWKIDEDRLEAVQRSHYGTFYDSCAYIIYAASLSGHYANHETITREQKPNVSL 90
            |.|..|:: ...||:|::..:..|..|.||:||...||::.          |   |.:||.:...
Zfish     8 FEKAGKYS-GLQIWRIEKMEIVPVPESFYGSFYTGDAYLVL----------H---TVKQKDSSFY 58

  Fly    91 ERYIHYWLGKNVSEQNRSNVVHKIQELDSYLGNISSIYRETQNLESARFLSYFKKGYEFRFSVRS 155
            :  :|:||||..|:...:.......::|.|||.....|||.|..||..|.||||.|.::    :|
Zfish    59 D--LHFWLGKECSQDESTAAAIFSTQMDDYLGGKPVQYREIQGFESTVFTSYFKGGIKY----KS 117

  Fly   156 GALISAPQR--------PRLFQLYARKWLRSIEVATIDWSHFNSDYVMVLQTDNLTYVWIGRSSS 212
            |.:.|..|.        .|||.:..|:.:|:.|| .:.|:.||:....::....:.|.|.|...:
Zfish   118 GGVASGFQHVITNDLTARRLFHIKGRRTVRATEV-PLSWASFNNGDCFIVDLGPVIYQWCGSKCN 181

  Fly   213 GIERRSAL-------DWVQKHCSGSPITIVDDGYEQAMSQEHKELWNTMLPLKKRMVCQASQLVS 270
            ..||..|.       |  .:....:.:.::::|.|.|...|       :|.:|.. :.:......
Zfish   182 KFERIKAAQVGTGIRD--NERSGRAKLVVIEEGQEPAEMTE-------VLGVKPE-IPEGDDSED 236

  Fly   271 EYADYNSNKF-RIYKCNQRGRLHLDQLDVGMPAKDD-------LSDAHGVYLLDNYGQS--IWLW 325
            ..||.::.|. .:|..:..    ..::.|.:.:||:       |||.  .::|| :|::  |::|
Zfish   237 AVADVSNRKMASLYMVSDA----TGKMQVSLVSKDNPFDQSNLLSDE--CFILD-HGKNKMIFVW 294

  Fly   326 VGGQAPQADALSAMGNGRAFVKKKKYPDNTLVVRVLEGHEPVEFKRLFANWLNVWQENTRGHKPV 390
            .|..|..::...||....:|:|:..||.||.:..:.||.|...||:.|.:|....|....|...|
Zfish   295 KGHNANPSERKEAMKTAESFIKQMGYPQNTQIQVLPEGGETPIFKQFFKSWKEKDQAEGLGRVFV 359

  Fly   391 STKFGKL-----DAHSLCERPKMAADTQLVDDGRGERVIYRV-----FGDQVQEVPISKTVVFTT 445
            :.:..|:     ||..|.|..:|||...:||||.|:..|:||     .||  .:||:..    .|
Zfish   360 TERIAKIKQEKFDASKLHESRQMAAQYNMVDDGAGKTEIWRVECGATKGD--TKVPVDP----ET 418

  Fly   446 NASFVVKYSVQCATVVPADLASVGIKTIIYQWNGSEASVESISRADKFAKASFD-GLKEPGMFVQ 509
            ...|   |...|..:    |.......|||.|.||.::::.:: |..|.....| .|....:.|:
Zfish   419 YGQF---YGGDCYII----LYRYSKGEIIYTWQGSRSTIDELT-ASAFLTVELDRSLGGNAVQVR 475

  Fly   510 LYEFDEPPHFLQIFEGKLII--------RRGQRTEMPYNGNSNALLDTFLLKVYGD-------AS 559
            :.:..||||.|.:|:.|.:|        :.||....|          |.|.:|..:       :.
Zfish   476 VTQGKEPPHLLSLFKDKPLIVYKDGTSRKGGQAPAAP----------TRLFQVRKNLGTITRISE 530

  Fly   560 YNAKAVEETHLSSISSKDCYVIK--TNHVWVWCGQSSTGDAREMAKAVGALMG-ENSLVLEGKES 621
            .:|||      ||::|.|.|::|  ....::|.|:.::.:..:.||.:...:. :..:|:||||.
Zfish   531 VDAKA------SSLNSNDVYLLKLPQGDGYIWKGKGASEEEEKAAKYMSEKLNCKTKMVVEGKEP 589

  Fly   622 KEFWQSVAMYFNQTLVINGNGNSCSSSTSSSSGAGSMCNGSSNGGNISPTLSNNCYLNTSVPSKP 686
            ..||.::                           |......::|...|.|:::
Zfish   590 DVFWMAL---------------------------GGKTEYQTSGLLESRTIAH------------ 615

  Fly   687 RPPVQLFLVWWQQSSLRYEEILG-FDQQDLSSDCTYILDTGSLTYVWLGSQAPNQERYTAI--AQ 748
              |.:||....:......||:.| |:|.||:.|...:||.....:||:|..|...||..::  |:
Zfish   616 --PPRLFACSNKTGKFIIEEVPGEFNQDDLAEDDVMLLDVWDSVFVWIGKDANEVERTESVKSAK 678

  Fly   749 SYVQNAPFGRRSATALAVVRQFQEPNVFKGFFESW 783
            .|::..|.||...|.|.||:|..||..|.|:|.:|
Zfish   679 IYIETDPSGRDKGTPLVVVKQGHEPPTFTGWFLAW 713

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
qua	NP_001246066.1	ADF_gelsolin	26..147	CDD:301701	39/120 (33%)
		gelsolin_like	164..254	CDD:200436	21/104 (20%)
		gelsolin_S3_like	276..375	CDD:200448	29/108 (27%)
		GEL	424..526	CDD:214590	29/107 (27%)
		ADF_gelsolin	551..625	CDD:301701	20/83 (24%)
		gelsolin_like	689..780	CDD:200436	33/93 (35%)
		VHP	857..892	CDD:128458
scin	NP_001038583.1	gelsolin_S1_like	8..119	CDD:200446	41/130 (32%)
		gelsolin_S2_like	136..223	CDD:200445	21/96 (22%)
		gelsolin_S3_like	244..344	CDD:200448	29/106 (27%)
		gelsolin_S4_like	388..489	CDD:200449	33/114 (29%)
		gelsolin_S5_like	511..601	CDD:200444	25/132 (19%)
		gelsolin_S6_like	616..714	CDD:200447	35/98 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1376537at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100298
Panther	1	1.100	-	-	O	PTHR11977
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.820