DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment qua and vill

DIOPT Version :9

Sequence 1:	NP_001246066.1	Gene:	qua / 35058	FlyBaseID:	FBgn0003187	Length:	892	Species:	Drosophila melanogaster
Sequence 2:	XP_021325987.1	Gene:	vill / 555361	ZFINID:	ZDB-GENE-081222-1	Length:	910	Species:	Danio rerio

Alignment Length:	913	Identity:	241/913 - (26%)
Similarity:	386/913 - (42%)	Gaps:	139/913 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 IWKIDEDRLEAVQRSHYGTFYDSCAYIIYAASLSGHYANHETITREQKPNVSLERYIHYWLGKNV 102
            ||.|::.::.||....:|.|::...|||...|              ..|..|::  ||||:|.:.
Zfish    79 IWTINKMQMVAVPEQAFGNFFEGDCYIILNVS--------------NNPAQSID--IHYWIGNSS 127

  Fly   103 SEQNRSNVVHKIQELDSYLGNISSIYRETQNLESARFLSYFKKGYEF-RFSVRSG---ALISAPQ 163
            |:..:......:.:||...|.....|||.|..||.:|.||||.|..: :..|.||   ...:...
Zfish   128 SQDEQGAAAIYVTQLDENFGGSPVQYREVQGHESVKFKSYFKNGLIYKKGGVASGFTHVETNVYN 192

  Fly   164 RPRLFQLYARKWLRSIEVATIDWSHFNSDYVMVLQTDNLTYVWIGRSSSGIERRSALDWVQ---- 224
            ..||..:...|.:...|| .:.|:.||...|.:|........|.|..|:..|:..|:...|
Zfish   193 IQRLLHVKGTKHVTGREV-EVSWNSFNLGDVFLLDLGKAIIQWNGPQSNRQEKLKAVMLAQDIRD 256

  Fly   225 -KHCSGSPITIVDDGYEQAMSQEHKELWNTMLPLKKRMVCQASQLV--SEYADYNSNKFRIYKCN 286
             :....:.|.:::...|:|    ..||...|:.:..:.:.|..:.:  .:......:..::|:.:
Zfish   257 RERGGRAQIGVIEGAQEEA----SPELMKVMVSVLGQRIGQMKEAIPDDKPGQNQISNVKLYQVS 317

  Fly   287 Q-RGRLHLDQLDVGMPAKDDLSDAHGVYLLDNYGQSIWLWVGGQAPQADALSAMGNGRAFVKKKK 350
            . .|:|.:.::.|. |...||..:...|:||..|.||.:|.|..|...:..||||....|:|.|.
Zfish   318 DASGQLLVQEVAVS-PLTQDLLCSSDCYILDQGGTSIMVWKGKGASNEERRSAMGRAVGFIKAKN 381

  Fly   351 YPDNTLVVRVLEGHEPVEFKRLFANWLNVWQENTRGH--------KPVSTKFGKLDAHSLCERPK 407
            ||.:|.|..:.||.|...||:||.:|....|....|.        |....||..::.|:   :||
Zfish   382 YPASTKVEVMSEGGESAMFKQLFKSWTEKGQTQGLGKTHSVGKIAKVDQVKFDVMELHA---QPK 443

  Fly   408 MAADTQLVDDGRGERVIYRVFGDQVQEVPISKTVVFTTNASFVVKYSVQCATVVPADLASVGIKT 472
            :||..::|||..|:..::|:...:::||..|....|.....::|.|:...|...         :.
Zfish   444 LAAQERMVDDASGQVQVWRIENLELKEVDRSTYGQFYGGDCYLVLYTYNRANKP---------QY 499

  Fly   473 IIYQWNGSEASVESISRADKFAKASFDGLKEPG--MFVQLYEFDEPPHFLQIFEGKLIIRRGQRT 535
            |:|.|.|..|:.:.:: |..:...:.|. |..|  ..|::....||.||:.||:|:|||..|...
Zfish   500 ILYIWQGRHATQDEVT-ASAYQAVNLDN-KYNGAPTQVRVVMGKEPRHFMAIFKGRLIIFEGGTG 562

  Fly   536 EMPYNGNSNALLDTFLLKVYGDASYNAKAVE-ETHLSSISSKDCYVIKT-NHVWVWCGQSSTGDA 598
            .   :|..|......|.:|.|....|.||.| ....||:::.|.:::|| ..|::|.|:..:||.
Zfish   563 R---SGVVNPDPAARLFQVRGTHELNTKATEVPARASSLNTNDVFLLKTYQTVFLWYGKGCSGDE 624

  Fly   599 REMAKAVGALMG--ENSLVLEGKESKEFWQSVAMYFNQTLVINGNGNSCSSSTSSSSGAGSMCNG 661
            |||.|||..|:.  :...|:||:|...||..:
Zfish   625 REMGKAVADLLSGQDKQTVMEGQEPAAFWVPL--------------------------------- 656

  Fly   662 SSNGGNISPTLSNNCYLNTSVPSKPRPPVQLFLVWWQQSSLRYEEILGFDQQDLSSDCTYILDTG 726
                |..:|..|:..........:||    ||....|.......|:..|.|.||..|...:|||.
Zfish   657 ----GGKAPYASDKRLEEEVSLHEPR----LFECSNQTGRFLMTEVADFTQDDLDEDDVMLLDTW 713

  Fly   727 SLTYVWLGSQAPNQ---ERYTAIAQSYVQNAPFGRRSATALAVVRQFQEPNVFKGFFESWQNDYG 788
            ...::|:|:.| ||   :..::.|..|::..|.||.:.|.:..|:|..||..|.|:|.:|.....
Zfish   714 DEIFLWIGNSA-NQYEIQESSSSAVEYLKTHPAGRDAGTPITTVKQGYEPPTFTGWFNAWDAHKW 777

  Fly   789 KNFHSYEKMRKDLG--------------NK-----VTSNCCFASEGSALILNNRQKDF---DG-- 829
            ....|||:|:..||              ||     |.:.......||....|.|....   ||
Zfish   778 SGGLSYEEMKSKLGDVSQITVSLNNTDLNKKPGGGVGNYSAPGGPGSIRSHNQRMSSVQFGDGSQ 842

  Fly   830 HKKYPLTV-----LIQEMDMLPPDINPLKREVHLTHDDFVSVFNMSFYEFDELPKWKKMELKKQF 889
            ::..|..:     |::..:.||..::|.|||.:|:..:|.::...:...|..||||::.:|||:.
Zfish   843 NRAKPSGMQNSEQLVKMPNQLPQGLDPEKREEYLSDAEFENLLGCTRANFQRLPKWRQNDLKKKA 907

  Fly   890 KLF 892
            .||
Zfish   908 GLF 910

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
qua	NP_001246066.1	ADF_gelsolin	26..147	CDD:301701	33/108 (31%)
		gelsolin_like	164..254	CDD:200436	21/94 (22%)
		gelsolin_S3_like	276..375	CDD:200448	34/99 (34%)
		GEL	424..526	CDD:214590	24/103 (23%)
		ADF_gelsolin	551..625	CDD:301701	28/77 (36%)
		gelsolin_like	689..780	CDD:200436	29/93 (31%)
		VHP	857..892	CDD:128458	10/34 (29%)
vill	XP_021325987.1	gelsolin_S1_like	68..178	CDD:200446	34/114 (30%)
		gelsolin_S2_like	194..282	CDD:200445	21/92 (23%)
		gelsolin_S3_like	309..406	CDD:200448	34/97 (35%)
		gelsolin_S4_like	450..550	CDD:200449	26/110 (24%)
		gelsolin_S5_like	571..661	CDD:200444	31/126 (25%)
		gelsolin_S6_like	676..773	CDD:200447	32/101 (32%)
		VHP	876..910	CDD:308044	10/33 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1376537at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100298
Panther	1	1.100	-	-	O	PTHR11977
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	7	6.780