DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment qua and Gel

DIOPT Version :9

Sequence 1:	NP_001246066.1	Gene:	qua / 35058	FlyBaseID:	FBgn0003187	Length:	892	Species:	Drosophila melanogaster
Sequence 2:	NP_524865.2	Gene:	Gel / 46008	FlyBaseID:	FBgn0010225	Length:	798	Species:	Drosophila melanogaster

Alignment Length:	826	Identity:	207/826 - (25%)
Similarity:	342/826 - (41%)	Gaps:	159/826 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 IWKIDEDRLEAVQRSHYGTFYDSCAYIIYAASLSGHYANHETITREQKPNVSLERYIHYWLGKNV 102
            ||:|:........:::||.||...::|:..             |.|.|.:..|...:|:|||...
  Fly    74 IWRIENFEPVIYPKTNYGKFYTGDSFIVLN-------------TIENKKDKKLSWDVHFWLGLET 125

  Fly   103 SEQNRSNVVHKIQELDSYLGNISSIYRETQNLESARFLSYFKKGYEF-RFSVRSG---ALISAPQ 163
            |............:||..|......:||.|:.||..||||||.|..: :..|.:|   ...:|..
  Fly   126 STDEAGAAAILTVQLDDLLNGGPVQHREVQDHESQLFLSYFKNGIRYEQGGVGTGFKHVETNAQG 190

  Fly   164 RPRLFQLYARKWLRSIEVATIDWSHFNSDYVMVLQTDNLTYVWIGRSSSGIERRSALDWV----- 223
            ..||||:..::.:| :....:..|..|:....:|...:..||::|..:..:|:..|:...
  Fly   191 ETRLFQVKGKRNVR-VRQVNLSVSSMNTGDCFILDAGSDIYVYVGSQAKRVEKLKAISAANQIRD 254

  Fly   224 QKHCSGSPITIVDDGYEQAMSQEHKELWNTMLPLKKRMVCQASQLVSEYADYNSNKFR------- 281
            |.|...:.:.||||....|..|...::..:         ..|.|:..|......:.|.
  Fly   255 QDHNGRARVQIVDDFSTDADKQHFFDVLGS---------GSADQVPDESTADEDSAFERTDAAAV 310

  Fly   282 -IYKCNQ-RGRLHLDQLDVGM-PAKDDLSDAHGVYLLDNYGQSIWLWVGGQAPQADALSAMGNGR 343
             :||.:. .|:|.:|  .:|. |....:.|....::||. |..|::|||..|.|.:...||...:
  Fly   311 SLYKVSDASGKLKVD--IIGQKPLTQAMLDTRECFILDT-GSGIFVWVGKGATQKEKTDAMAKAQ 372

  Fly   344 AFVKKKKYPDNTLVVRVLEGHEPVEFKRLFANWLNVWQENTRGHKPVSTKFGKLDAHSLCERPKM 408
            .|::.||||..|.:.|::||.|...||:.|..|.:....::|   .:.:..|......|.:....
  Fly   373 EFLRTKKYPAWTQIHRIVEGSESAPFKQYFDTWRDAGMSHSR---LIRSALGIGSDELLNDDEID 434

  Fly   409 AADTQLVDDG---------RGERVIYRVF-------GDQ--VQEVPISKTVVFTTNASFVVKYSV 455
            :..|||...|         .|:.||..:.       .|:  |..||..:.:.....||:|:.|:.
  Fly   435 SVVTQLKKSGGRAFGFMPDHGQNVIETITQYVAKPGSDEIVVSTVPFDEKLPLLGFASYVLTYNY 499

  Fly   456 QCATVVPADLASVGIKTIIYQWNGSEASVESISRADKFAKASFDGL--KEPGMFVQLYEFDEPPH 518
            :      |:....|  ::.|.|:|.:||..:..||.:      :||  .:.|:.||..:..||.|
  Fly   500 E------ANNGDTG--SLTYVWHGVKASAAARKRAFE------EGLVGSKDGLLVQTNQGHEPRH 550

  Fly   519 FLQIFEGKLIIRRGQRTEMPYNGNSNALLDTFLLKVYGDASYNAKAVE-ETHLSSISSKDCYVI- 581
            |.:||:|||:.   ..|.:|....        |.::.|....:..|.| ....||::|.|.:|:
  Fly   551 FYKIFKGKLLT---SFTALPVTAQ--------LFRIRGTVESDVHASEVAADSSSLASSDAFVLH 604

  Fly   582 --KTNHVWVWCGQSSTGDAREMAKAVGALMG-----ENSLVLEGKESKEFWQSVAMYFNQTLVIN 639
              |::.:::|.|..::  |.|...||.....     |...|.||.|..|||:.          :|
  Fly   605 SGKSHKIYIWNGLGAS--AFEKQAAVDRFSDYWDDVELEQVEEGAEPDEFWEE----------LN 657

  Fly   640 GNGNSCSSSTSSSSGAGSMCNGSSNGGNISPTLSN---NCYLNTSVPSKPRPPVQLFLVWWQQSS 701
            |.|.                ...|.|.:.:|.|.:   :|:|::.                  ..
  Fly   658 GEGQ----------------YDRSLGDDGAPLLESRLFHCHLSSG------------------GF 688

  Fly   702 LRYEEILGFDQQDLSSDCTYILDTGSLTYVWLGSQAPNQE--RYTAIAQSYVQNAPFGRRSATAL 764
            |:.||:..::|:||.||...:||.|...|:|:|.....:|  :....|:.|....|.. ||...:
  Fly   689 LKVEEVAQYEQEDLDSDDIMLLDAGDEIYLWVGYGVSEEENGKLLDTAKLYFNLEPTA-RSFDTV 752

  Fly   765 AVVR--QFQEPNVFKGFFESWQNDYGKNFHSYEKMRK---DLGNKV 805
            :::|  |.:||.|||..|.:|.::|.:|..|||.|::   |..|:|
  Fly   753 SIIRVPQGKEPRVFKRMFPNWDDNYWQNQPSYEDMKQLVIDANNEV 798

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
qua	NP_001246066.1	ADF_gelsolin	26..147	CDD:301701	31/108 (29%)
		gelsolin_like	164..254	CDD:200436	21/94 (22%)
		gelsolin_S3_like	276..375	CDD:200448	33/108 (31%)
		GEL	424..526	CDD:214590	29/112 (26%)
		ADF_gelsolin	551..625	CDD:301701	22/82 (27%)
		gelsolin_like	689..780	CDD:200436	27/94 (29%)
		VHP	857..892	CDD:128458
Gel	NP_524865.2	gelsolin_S1_like	63..176	CDD:200446	32/114 (28%)
		gelsolin_S2_like	191..283	CDD:200445	21/92 (23%)
		gelsolin_S3_like	307..404	CDD:200448	32/99 (32%)
		ADF_gelsolin	470..558	CDD:301701	28/101 (28%)
		ADF_gelsolin	569..661	CDD:301701	26/111 (23%)
		gelsolin_S6_like	675..774	CDD:200447	30/117 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0443
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.861654	Normalized mean entropy	S5343
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1376537at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100298
Panther	1	1.100	-	-	P	PTHR11977
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.770