DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment qua and vil1

DIOPT Version :9

Sequence 1:	NP_001246066.1	Gene:	qua / 35058	FlyBaseID:	FBgn0003187	Length:	892	Species:	Drosophila melanogaster
Sequence 2:	NP_956532.1	Gene:	vil1 / 393207	ZFINID:	ZDB-GENE-040426-799	Length:	834	Species:	Danio rerio

Alignment Length:	898	Identity:	247/898 - (27%)
Similarity:	398/898 - (44%)	Gaps:	128/898 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 IWKIDEDRLEAVQRSHYGTFYDSCAYIIYAASLSGHYANHETITREQKPNVSLERYIHYWLGKNV 102
            ||:::...|.......:|.|::..:|:|             ..|.:...|.|.:  |||||||:.
Zfish    22 IWRVENMELVPCPSKTFGQFFEGDSYVI-------------LYTHKTSNNFSYD--IHYWLGKST 71

  Fly   103 SEQNRSNVVHKIQELDSYLGNISSIYRETQNLESARFLSYFKKGYEFRFSVRSGALISAPQR--- 164
            |:...........::|.:||.::..:||||..|||.|..|||:|..:    :.|.:.|..::
Zfish    72 SQDEMGAAAIYTTQMDDHLGGVAVQHRETQGHESATFQGYFKQGIIY----KKGGVASGMKQVET 132

  Fly   165 -----PRLFQLYARKWLRSIEVATIDWSHFNSDYVMVLQTDNLTYVWIGRSSSGIER----RSAL 220
                 .||..:...|.:.:.|| .:.|:.||...|.:|...:|...|.|..|:.:||    ..|.
Zfish   133 NTYNIRRLLHVKGNKHVVAGEV-EMSWNSFNKGDVFLLDLGSLIIQWNGPKSNRMERLRGMNLAK 196

  Fly   221 DWVQKHCSGSPITIVDDGYEQAMSQEHKELWNTMLPLKKRMVCQA--SQLVSEYADYNSNKFRIY 283
            |...:...|.....|.:|.::..|:|..:|....|..:.:.:.:|  .::|.|..   ....::|
Zfish   197 DIRDRERGGRAQVAVVEGDDEQSSEEAMKLMKQSLGERPKNIKEAIPDEIVDEKL---KTAIKLY 258

  Fly   284 KCNQ-RGRLHLDQLDVGMPAKDDLSDAHGVYLLDNYGQSIWLWVGGQAPQADALSAMGNGRAFVK 347
            ..:. :|.|.:.::.| .|...||......||||..|..|::|.|.:|.:|:...::....|:||
Zfish   259 HISDAQGSLVVQEVAV-KPLTQDLLKTEDCYLLDQGGIKIFIWKGKKASKAERTESLKMAEAYVK 322

  Fly   348 KKKYPDNTLVVRVLEGHEPVEFKRLFANWLNVWQENTRG--HKP---VSTKFGKLDAHSLCERPK 407
            .|.||.:|.:..|.||.|...||:||..|.:..|....|  |.|   ...:..|.||.|:..||.
Zfish   323 AKGYPVSTYIETVSEGAESSVFKQLFQKWTDKGQTVGMGTTHNPGKIAKVEQVKFDATSMHARPD 387

  Fly   408 MAADTQLVDDGRGERVIYRVFGDQVQEVPISKTVVFTTNASFVVKYSVQCATVVPADLASVGIKT 472
            :||..::||||.||..::|:..:::..|.......|.....:::.|..:         .|.....
Zfish   388 IAAQQKMVDDGSGEAEVWRIEDNELAPVDRKWLGHFYGGDCYLILYKYE---------VSSKFHY 443

  Fly   473 IIYQWNGSEASVESISRADKFA---KASFDGLKEPGMFVQLYEFDEPPHFLQIFEGKLII-RRGQ 533
            |:|.|.|..||...::.....|   ...::|  || :.|::....||.|.:.||:||:|: ..|.
Zfish   444 ILYMWQGRHASTAELTACAYQAVILDQKYNG--EP-VQVRVPMGKEPMHLMAIFKGKMIVYEEGS 505

  Fly   534 RTEMPYNGNSNALLDTFLLKVYGDASYNAKAVE-ETHLSSISSKDCYVIKTNH-VWVWCGQSSTG 596
            ..|    |:|.:.....|..|:|...:|.:|.| ....||::|.|.:|:.|:. .::|.|:..:|
Zfish   506 SRE----GSSQSRPSVRLFHVHGTNEFNTRATEVPPRSSSLNSNDVFVLSTDKCCYLWYGKGCSG 566

  Fly   597 DAREMAKAVGALMG--ENSLVLEGKESKEFWQSVAMYFNQTLVINGNGNSCSSSTSSSSGAGSMC 659
            |.|||||::..::.  |..::.||:|..:||            :|..|.|..:|
Zfish   567 DEREMAKSLADIISEREKQVIAEGQEPADFW------------VNLGGKSQYAS----------- 608

  Fly   660 NGSSNGGNISPTLSNNCYLNTSVPSKPRPPVQLFLVWWQQSSLRYEEILGFDQQDLSSDCTYILD 724
            |......|||.|              ||    ||....|.......||..|:|.||..|...:||
Zfish   609 NKRLQDENISIT--------------PR----LFECSNQTGRFIATEITNFNQDDLDEDDVMLLD 655

  Fly   725 TGSLTYVWLGSQAPNQERYTAI--AQSYVQNAPFGRRSATALAVVRQFQEPNVFKGFFESWQNDY 787
            .....|:|:|..|.:.|:..|:  ||.|:::.|.||...|.:.||:|..||..|.|:|.:|....
Zfish   656 IWDQVYLWIGKGANDTEKREAVVTAQEYLKSHPAGRDLDTPVLVVKQGFEPPTFTGWFHAWDPQK 720

  Fly   788 GKNFHSYEKMRKDLGN-----KVTSNCCFASEGSALILNNRQKDFDGHKKYPLT--------VLI 839
            .....||::::.:||:     |:|.:....|.......|:.|   .|....|:|        |.:
Zfish   721 WSEGKSYDQLKAELGDATDVIKITVDLTQPSSNQTNSSNSTQ---GGSMPRPVTQTFPAEKLVNV 782

  Fly   840 QEMDMLPPDINPLKREVHLTHDDFVSVFNMSFYEFDELPKWKKMELKKQFKLF 892
            |..| ||..::|.::|.:|:.|||.....:|...|..:|.||::.|||:..||
Zfish   783 QTED-LPEGVDPTRKEDYLSDDDFALAMGISRMNFYAMPSWKQLNLKKEKGLF 834

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
qua	NP_001246066.1	ADF_gelsolin	26..147	CDD:301701	32/108 (30%)
		gelsolin_like	164..254	CDD:200436	24/101 (24%)
		gelsolin_S3_like	276..375	CDD:200448	32/99 (32%)
		GEL	424..526	CDD:214590	21/104 (20%)
		ADF_gelsolin	551..625	CDD:301701	25/77 (32%)
		gelsolin_like	689..780	CDD:200436	32/92 (35%)
		VHP	857..892	CDD:128458	12/34 (35%)
vil1	NP_956532.1	gelsolin_S1_like	18..122	CDD:200446	33/118 (28%)
		gelsolin_S2_like	139..225	CDD:200445	23/86 (27%)
		gelsolin_S3_like	252..350	CDD:200448	32/98 (33%)
		gelsolin_S4_like	394..494	CDD:200449	25/111 (23%)
		gelsolin_S5_like	515..605	CDD:200444	29/101 (29%)
		gelsolin_S6_like	621..717	CDD:200447	35/99 (35%)
		VHP	800..834	CDD:280388	12/33 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1376537at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100298
Panther	1	1.100	-	-	O	PTHR11977
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	7	6.780