DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment qua and gsna

DIOPT Version :9

Sequence 1:	NP_001246066.1	Gene:	qua / 35058	FlyBaseID:	FBgn0003187	Length:	892	Species:	Drosophila melanogaster
Sequence 2:	XP_021324427.1	Gene:	gsna / 321099	ZFINID:	ZDB-GENE-030131-9653	Length:	738	Species:	Danio rerio

Alignment Length:	787	Identity:	201/787 - (25%)
Similarity:	345/787 - (43%)	Gaps:	118/787 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 IWKIDEDRLEAVQRSHYGTFYDSCAYIIYAASLSGHYANHETITREQKPNVSLERYIHYWLGKNV 102
            :|:|::..|.||..:.||.||...||::...            |::...|:..:  :|:|||...
Zfish    18 VWRIEKFDLVAVPENLYGGFYTGDAYLVLKT------------TKQTSGNLQYD--LHFWLGDYC 68

  Fly   103 SEQNRSNVVHKIQELDSYLGNISSIYRETQNLESARFLSYFKKGYEF-RFSVRSG---ALISAPQ 163
            ::....:......::|.|||.....|||.|..||..||.|||||.:: :..|.||   .:.:...
Zfish    69 TQDESGSAAIFTVQMDDYLGGKPIQYREVQGHESKAFLGYFKKGLQYMQGGVASGFKHVVTNEVV 133

  Fly   164 RPRLFQLYARKWLRSIEVATIDWSHFNSDYVMVLQTDNLTYVWIGRSSSGIERRSALDWVQ---- 224
            ..|:.|:..|:.:|:.|| .:.|..||.....:|...|..|.|.|..|:..|:..|....:
Zfish   134 MQRVLQVKGRRVVRATEV-PVSWDSFNQGDCFILDLGNEIYQWCGSKSNRFEKLKATQLAKGIRD 197

  Fly   225 -KHCSGSPITIVDDGYEQAMSQEHKELWNTMLPLKKRMVCQASQLVSEYADYNSNKF-RIYKCNQ 287
             :....:.:.:.|:|.|:....|       :|..|..:...||..|.  ||.::.|. ::||.:.
Zfish   198 NERSGRARVYVCDEGVEREKMLE-------VLGEKPDLPEGASDDVK--ADASNRKMAKLYKVSD 253

  Fly   288 -RGRLHLDQLDVGMPAKDDLSDAHGVYLLDNYGQ-SIWLWVGGQAPQADALSAMGNGRAFVKKKK 350
             .|.:.:..:....|......::...::||:... .|::|.|..|...:..:||.....|:||..
Zfish   254 ASGDMAIALVAAENPFTQSALESSDCFILDHGSDGKIFVWKGKDANMEERKAAMKAADEFIKKMG 318

  Fly   351 YPDNTLVVRVLEGHEPVEFKRLFANWLNVWQENTRGHKPVSTKFGKL-----DAHSLCERPKMAA 410
            ||.:|.|..:.|..|...||:.|.||.:|.|....|...||....|:     ||.:|.:.|.|||
Zfish   319 YPKHTQVQILPEMGETPLFKQFFKNWRDVDQTEGMGVAYVSNSIAKIEKVPFDASTLHDSPAMAA 383

  Fly   411 DTQLVDDGRGERVIYRVFGDQVQEVPISKTVV--FTTNASFVVKYSVQCATVVPADLASVGIK-T 472
            ...::|.|.||:.|:|:.|.  .:||:..:..  |....|:::.||.:..          |.: .
Zfish   384 QHGMIDSGNGEKQIWRIEGS--DKVPVDPSTYGQFYGGDSYIILYSYRHG----------GRQGH 436

  Fly   473 IIYQWNGSEASVESISRADKFAKASFDGLKEPGMF----------VQLYEFDEPPHFLQIFEGK- 526
            |||.|.|::::.:.|. |.....|..|.....|..          |::.:..||.|.:.:|.|:
Zfish   437 IIYIWQGADSTQDEIG-ASAILGAQLDDELGGGPVQMAGAPLTTQVRVVQGKEPAHLMSLFGGQP 500

  Fly   527 LIIRRGQRTEMPYNGNSNALLDTFLLKVYGDASYNAKAVEETHLSS-ISSKDCYVIKTNHV-WVW 589
            :::.:|..:.   .|...|..:|.|.:|..:::...:|||...:|| ::|.|.:|:.|... ::|
Zfish   501 MVVHKGGTSR---EGGQTAPAETRLFQVRSNSAGCTRAVEIDAVSSNLNSNDAFVLVTPAASFIW 562

  Fly   590 CGQSSTGDAREMAKAVGALMGEN-SLVLEGKESKEFWQSVAMYFNQTLVINGNGNSCSSSTSSSS 653
            .||.::...:..|:.:..::|.: |.:.||.|...||.::             |...:..|||
Zfish   563 VGQGASDIEKRGAQQLCGILGVSPSELSEGGEDGGFWDAL-------------GGKAAYRTSS-- 612

  Fly   654 GAGSMCNGSSNGGNISPTLSNNCYLNTSVPSKPRPPVQLFLVWWQQSSLRYEEILG-FDQQDLSS 717
                         .:...::.:             |.:||....:......||:.| ..|:||::
Zfish   613 -------------RLKDKMNAH-------------PPRLFACSNKTGRFIIEEVPGEMTQEDLAT 651

  Fly   718 DCTYILDTGSLTYVWLGSQAPNQERYTAI--AQSYVQNAPFGRRSATALAVVRQFQEPNVFKGFF 780
            |...||||....:||:|::|.::|:..|:  |..|:|..|..|...||:..::|..||..|.|:|
Zfish   652 DDVMILDTWDQVFVWIGNEAHDEEKMEAMTSAAQYIQTDPANRDPRTAIVKIKQGFEPPTFTGWF 716

  Fly   781 ESWQNDY 787
            ..|.:||
Zfish   717 LGWDHDY 723

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
qua	NP_001246066.1	ADF_gelsolin	26..147	CDD:301701	33/108 (31%)
		gelsolin_like	164..254	CDD:200436	21/94 (22%)
		gelsolin_S3_like	276..375	CDD:200448	25/101 (25%)
		GEL	424..526	CDD:214590	25/114 (22%)
		ADF_gelsolin	551..625	CDD:301701	20/76 (26%)
		gelsolin_like	689..780	CDD:200436	32/93 (34%)
		VHP	857..892	CDD:128458
gsna	XP_021324427.1	gelsolin_S1_like	7..119	CDD:200446	34/114 (30%)
		gelsolin_S2_like	135..223	CDD:200445	21/95 (22%)
		gelsolin_S3_like	243..343	CDD:200448	25/99 (25%)
		gelsolin_S4_like	387..496	CDD:200449	28/121 (23%)
		gelsolin_S5_like	518..606	CDD:200444	24/100 (24%)
		gelsolin_S6_like	622..720	CDD:200447	33/97 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1376537at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100298
Panther	1	1.100	-	-	O	PTHR11977
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.820