DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment qua and Scin

DIOPT Version :9

Sequence 1:	NP_001246066.1	Gene:	qua / 35058	FlyBaseID:	FBgn0003187	Length:	892	Species:	Drosophila melanogaster
Sequence 2:	NP_942043.1	Gene:	Scin / 298975	RGDID:	735034	Length:	715	Species:	Rattus norvegicus

Alignment Length:	821	Identity:	195/821 - (23%)
Similarity:	327/821 - (39%)	Gaps:	179/821 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 FRKVAKHAITFAIWKIDEDRLEAVQRSHYGTFYDSCAYIIYAASLSGHYANHETITREQKPNVSL 90
            |.:..|.| ...:|::::..|..|.:..||.||...||::.          |.|     |.:...
  Rat    10 FARAGKQA-GLQVWRVEKLELVPVPQGAYGDFYVGDAYLVL----------HTT-----KSSRGF 58

  Fly    91 ERYIHYWLGKNVSEQNRSNVVHKIQELDSYLGNISSIYRETQNLESARFLSYFKKGYEFRF-SVR 154
            ...:|:||||..|:...:.......::|.|||......||.|..||..|:.|||.|.:::. .|.
  Rat    59 SYRLHFWLGKECSQDESTAAAIFTVQMDDYLGGKPVQSRELQGYESTDFVGYFKGGLKYKAGGVA 123

  Fly   155 SG---ALISAPQRPRLFQLYARKWLRSIEVATIDWSHFNSDYVMVLQTDNLTYVWIGRSSSGIER 216
            ||   .|.:.....||..:..|:.:|:.|| .:.|..||.....::......|.|.|.|.:..||
  Rat   124 SGLNHVLTNDLTAKRLLHVKGRRVVRATEV-PLSWQSFNKGDCFIIDLGTEIYQWCGSSCNKYER 187

  Fly   217 RSALDWVQKHCSG---------SPITIVDDGYEQAMSQEHKELWNTM-----LP----------- 256
            ..|    .:..:|         |.:.:|::|      .|..||...:     ||
  Rat   188 LKA----SQVATGIRDNERKGRSQLIVVEEG------SEPPELMKVLGRKPELPDGDNDDDVIAD 242

  Fly   257 ------LKKRMVCQAS-----QLVSEYADYNSNKFRIYKCNQRGRLHLDQLDVGMPAKDDLSDAH 310
                  .|..||..||     .||:|     .|.|                .:||...::
  Rat   243 ISNRKMAKLYMVSDASGSMKVTLVAE-----ENPF----------------SMGMLLPEE----- 281

  Fly   311 GVYLLDN-YGQSIWLWVGGQAPQADALSAMGNGRAFVKKKKYPDNTLVVRVLEGHEPVEFKRLFA 374
             .::||: ..:.|::|.|..|...:..:||.....|:.|..|..||.:..:.||.|...||:.|.
  Rat   282 -CFILDHGAAKQIFVWKGKNANPQERKTAMKTAEEFLHKMNYSANTQIQVLPEGGETPIFKQFFK 345

  Fly   375 NWLNVWQENTRGHKPVSTKFGKL-----DAHSLCERPKMAADTQLVDDGRGERVIYRVFGDQVQE 434
            :|.:..|.:..|...::.|..::     ||..|...|:|||...:||||.|...|:||......:
  Rat   346 DWKDKDQSDGFGKVYITEKVAQIKQIPFDASKLHSSPQMAAQHNMVDDGSGGVEIWRVENSGRVQ 410

  Fly   435 VPISKTVVFTTNASFVVKYSVQCATVVPADLASVGIKTIIYQWNGSEASVESISRADKFAKASFD 499
            :..|....|.....:::.|:....             .|||.|.|::|:.:.::.: .|.....|
  Rat   411 IDPSSYGEFYGGDCYIILYTYPRG-------------QIIYTWQGADATRDELTMS-AFLTVQLD 461

  Fly   500 -GLKEPGMFVQLYEFDEPPHFLQIFEGKLII-------RRGQRTEMPYNGNSNALLDTFLLKVYG 556
             .|....:.|::.:..||.|.|.:|:.|.:|       ::|.:...|         .|.|.:|..
  Rat   462 RSLGGQAVQVRVSQGKEPAHLLSLFKDKPLIIYKNGTSKKGGQAPAP---------PTRLFQVRR 517

  Fly   557 DASYNAKAVE-ETHLSSISSKDCYVIK--TNHVWVWCGQSSTGDAREMAKAVG-ALMGENSLVLE 617
            :.:...:.|| :...:|::|.|.:|:|  .|:.::|.|:.::.:..:.|:.|. .|..:.:.:.|
  Rat   518 NLASITRIVEVDVDTNSLNSNDTFVLKLPRNNGFIWIGKGASQEEEKGAEYVADVLKCKTTRIQE 582

  Fly   618 GKESKEFWQSVAMYFNQTLVINGNGNSCSSSTSSSSGAGSMCNGSSNGGNISPTLSNNCYLNTSV 682
            |||..|||.|          :.|.|:.                      ..||.|...
  Rat   583 GKEPDEFWNS----------LGGRGDY----------------------QTSPLLETQ------- 608

  Fly   683 PSKPRPPVQLFLVWWQQSSLRYEEILG-FDQQDLSSDCTYILDTGSLTYVWLGSQAPNQERYTAI 746
             ::..|| :|:....:......||:.| |.|.||:.|...:||.....::|:|..|...|:..::
  Rat   609 -AEDHPP-RLYGCSNKTGRFIIEEVPGEFTQDDLAEDDVMLLDAWEQIFIWIGKDANEVEKKESV 671

  Fly   747 --AQSYVQNAPFGRRSATALAVVRQFQEPNVFKGFFESWQN 785
              |:.|::..|.||...|.:.:::|..||..|.|:|..|.:
  Rat   672 KSAKMYLETDPSGRDKRTPIVIIKQGHEPPTFTGWFLGWDS 712

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
qua	NP_001246066.1	ADF_gelsolin	26..147	CDD:301701	34/120 (28%)
		gelsolin_like	164..254	CDD:200436	23/98 (23%)
		gelsolin_S3_like	276..375	CDD:200448	23/99 (23%)
		GEL	424..526	CDD:214590	21/102 (21%)
		ADF_gelsolin	551..625	CDD:301701	20/77 (26%)
		gelsolin_like	689..780	CDD:200436	27/93 (29%)
		VHP	857..892	CDD:128458
Scin	NP_942043.1	gelsolin_S1_like	10..121	CDD:200446	35/126 (28%)
		gelsolin_S2_like	136..225	CDD:200445	23/99 (23%)
		gelsolin_S3_like	246..346	CDD:200448	31/126 (25%)
		gelsolin_S4_like	390..486	CDD:200449	25/109 (23%)
		gelsolin_S5_like	508..598	CDD:200444	26/108 (24%)
		gelsolin_S6_like	613..711	CDD:200447	29/98 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1376537at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100298
Panther	1	1.100	-	-	O	PTHR11977
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.820