DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment qua and Gsn

DIOPT Version :9

Sequence 1:	NP_001246066.1	Gene:	qua / 35058	FlyBaseID:	FBgn0003187	Length:	892	Species:	Drosophila melanogaster
Sequence 2:	NP_001004080.1	Gene:	Gsn / 296654	RGDID:	1303089	Length:	780	Species:	Rattus norvegicus

Alignment Length:	816	Identity:	216/816 - (26%)
Similarity:	351/816 - (43%)	Gaps:	131/816 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 TEIRPNTI----PDLKVDATFRKVAKHAITFAIWKIDEDRLEAVQRSHYGTFYDSCAYIIYAASL 70
            :|.||:|:    |:      |.|..|.. ...||::::..|..|..:.||.|:...||:|.
  Rat    43 SETRPSTMVVEHPE------FLKAGKEP-GLQIWRVEKFDLVPVPPNLYGDFFTGDAYVIL---- 96

  Fly    71 SGHYANHETITREQKPNVSLERYIHYWLGKNVSEQNRSNVVHKIQELDSYLGNISSIYRETQNLE 135
                   :|:   |..|.:|:..:|||||...|:...........:||.||...:..:||.|..|
  Rat    97 -------KTV---QLRNGNLQYDLHYWLGNECSQDESGAAAIFTVQLDDYLNGRAVQHREVQGFE 151

  Fly   136 SARFLSYFKKGYEF-RFSVRSGALISAPQR---PRLFQLYARKWLRSIEVATIDWSHFNSDYVMV 196
            |:.|..|||.|.:: :..|.||.....|..   .||||:..|:.:|:.|| .:.|..||:....:
  Rat   152 SSTFQGYFKSGLKYKKGGVASGFKHVVPNEVVVQRLFQVKGRRVVRATEV-PVSWDSFNNGDCFI 215

  Fly   197 LQTDNLTYVWIGRSSSGIERRSALDWVQK-----HCSG-SPITIVDDGYE-QAMSQEHKELWNTM 254
            |...|..|.|.|..|:..||..|.. |.|     ..|| :.:.:.::|.| :||.|       .:
  Rat   216 LDLGNNIYQWCGSGSNKFERLKATQ-VSKGIRDNERSGRAQVHVSEEGSEPEAMLQ-------VL 272

  Fly   255 LPLKKRMVCQASQLVSEYADYNSNKFRIYK-CNQRGRLHLDQLDVGMPAKDDLSDAHGVYLLDNY 318
            .|  |..:.|.::..::....|....::|| .|..|.:.:..:....|.......:...::|| :
  Rat   273 GP--KPDLPQGTEDTAKEDAANRRLAKLYKVSNSGGSMSVSLVADENPFAQSALRSEDCFILD-H 334

  Fly   319 GQ--SIWLWVGGQAPQADALSAMGNGRAFVKKKKYPDNTLVVRVLEGHEPVEFKRLFANWLNVWQ 381
            |:  .|::|.|.||...:..:|:.....|:.|.:||..|.|..:.||.|...||:.|.||.:..|
  Rat   335 GRDGKIFVWKGKQANMDERKAALKTASDFISKMQYPRQTQVSVLPEGGETPLFKQFFKNWRDPDQ 399

  Fly   382 ENTRGHKPVSTKFGKL-----DAHSLCERPKMAADTQLVDDGRGERVIYRVFGDQVQEVPISKTV 441
            .:..|...:|:....:     ||.:|.....|||...:.|||.|::.|:|:.|.....|..:...
  Rat   400 TDGPGLSYLSSHIANVERVPFDAATLHTSTAMAAQHGMDDDGTGQKQIWRIEGSNKVLVDPATYG 464

  Fly   442 VFTTNASFVVKYSVQCATVVPADLASVGIK-TIIYQWNGSEASVESISRADKFAKASFDGLKEPG 505
            .|....|:::.|:.:..          |.: .|||.|.|::::.:.:: |.....|..|  :|.|
  Rat   465 QFYGGDSYIILYNYRHG----------GRQGQIIYNWQGAQSTQDEVA-ASAILTAQLD--EELG 516

  Fly   506 ---MFVQLYEFDEPPHFLQIFEGK-LIIRRGQRTEMPYNGNSNALLDTFLLKVYGDASYNAKAVE 566
               :..::.:..||.|.:.:|.|| :||.:|..:.   :|.......|.|.:|...:|...:|||
  Rat   517 GTPVQSRVVQGKEPAHLMSLFGGKPMIIYKGGTSR---DGGQTTPASTRLFQVRASSSGATRAVE 578

  Fly   567 -ETHLSSISSKDCYVIKT---NHVWVWCGQS---STGDAREMAKAVGALMGENSLVLEGKESKEF 624
             .....:::|.|.:|:||   .::||..|.|   .|| |.|:.|   .|..::..|.||.|...|
  Rat   579 VMPKAGALNSNDAFVLKTPSAAYLWVGTGASDAEKTG-ALELLK---VLRAQHVQVEEGSEPDGF 639

  Fly   625 WQSVAMYFNQTLVINGNGNSCSSSTSSSSGAGSMCNGSSNGGNISPTLSNNCYLNTSVPSKPRPP 689
            |:::                                |.......||.|.:.       .....||
  Rat   640 WEAL--------------------------------GGKTAYRTSPRLKDK-------KMDAHPP 665

  Fly   690 VQLFLVWWQQSSLRYEEILG-FDQQDLSSDCTYILDTGSLTYVWLGSQAPNQERYTAI--AQSYV 751
             :||....:......||:.| ..|:||::|...:|||....:||:|..:..:|:..|:  |:.|:
  Rat   666 -RLFACSNRIGRFVIEEVPGELMQEDLATDDVMLLDTWDQVFVWVGKDSQEEEKTEALTSAKRYI 729

  Fly   752 QNAPFGRRSATALAVVRQFQEPNVFKGFFESWQNDY 787
            :..|..|...|.:.||||..||..|.|:|..|.:||
  Rat   730 ETDPANRDRRTPITVVRQGFEPPSFVGWFLGWDDDY 765

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
qua	NP_001246066.1	ADF_gelsolin	26..147	CDD:301701	36/120 (30%)
		gelsolin_like	164..254	CDD:200436	29/99 (29%)
		gelsolin_S3_like	276..375	CDD:200448	27/101 (27%)
		GEL	424..526	CDD:214590	22/105 (21%)
		ADF_gelsolin	551..625	CDD:301701	25/80 (31%)
		gelsolin_like	689..780	CDD:200436	31/93 (33%)
		VHP	857..892	CDD:128458
Gsn	NP_001004080.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	28..48		2/4 (50%)
		Actin-severing. /evidence=ECO:0000255	51..174		40/143 (28%)
		gelsolin_S1_like	57..169	CDD:200446	37/126 (29%)
		Actin-actin interfilament contact point. /evidence=ECO:0000250	121..124		0/2 (0%)
		Polyphosphoinositide binding. /evidence=ECO:0000250	160..167		2/6 (33%)
		gelsolin_S2_like	184..273	CDD:200445	29/97 (30%)
		Polyphosphoinositide binding. /evidence=ECO:0000250	186..194		4/7 (57%)
		Gelsolin-like 2	196..236		13/40 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	244..286		10/50 (20%)
		gelsolin_S3_like	296..393	CDD:200448	26/97 (27%)
		Gelsolin-like 3	312..354		9/42 (21%)
		Actin-binding, Ca-sensitive. /evidence=ECO:0000255	432..780		102/394 (26%)
		gelsolin_S4_like	437..537	CDD:200449	25/112 (22%)
		gelsolin_S5_like	559..647	CDD:200444	29/123 (24%)
		gelsolin_S6_like	664..762	CDD:200447	33/98 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1376537at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100298
Panther	1	1.100	-	-	O	PTHR11977
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.820