DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment qua and Vill

DIOPT Version :9

Sequence 1:	NP_001246066.1	Gene:	qua / 35058	FlyBaseID:	FBgn0003187	Length:	892	Species:	Drosophila melanogaster
Sequence 2:	XP_006512122.1	Gene:	Vill / 22351	MGIID:	1201781	Length:	865	Species:	Mus musculus

Alignment Length:	952	Identity:	249/952 - (26%)
Similarity:	401/952 - (42%)	Gaps:	201/952 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 IWKIDED--RLEAVQRSHYGTFYDSCAYIIYAASLSGHYANHETITREQKPNVSLERY--IHYWL 98
            || |.|:  .|...:|:| |.|::.|.|::              :...|.|..:...:  :|||:
Mouse    18 IW-ITENLKMLPLPERAH-GNFFEECCYVV--------------LHVPQSPKATQGGFSDLHYWI 66

  Fly    99 GKNVSEQNRSNVVHKIQELDSYLGNISSIYRETQNLESARFLSYFKKGYEFRFSVRSGALISAPQ 163
            ||:.|.:.|...|..:|.|...||:.:.::||:|..||..|.|||..|..:|...|..||..|..
Mouse    67 GKDASAEAREAAVSFVQCLQEDLGDQTVLHRESQGHESDCFHSYFHPGVIYRKGGRDSALKFAET 131

  Fly   164 R----PRLFQLYARKWLRSIEVATIDWSHFNSDYVMVLQTDNLTYVWIGRSSSGIERRSALDWV- 223
            .    .||..:..||.:.:.||| :.|:.||...:.:|....:...|.|..:|..|:..||...
Mouse   132 NMYNVQRLLHIRGRKHVSATEVA-LSWNSFNKGDIFLLDLGKVMIQWNGPKASISEKARALTLTC 195

  Fly   224 ----QKHCSGSPITIVDDGYEQAMSQEHKELWNTMLPLKKRMVCQASQL--------VSEYADYN 276
                ::....:.|.:||         ...|..|.:..::..:.|::..|        ||:....|
Mouse   196 NLRDRERGGRAQIAVVD---------AENEATNLLRIMEAVLGCRSGSLCPSVPSNSVSQLQKAN 251

  Fly   277 SNKFRIYKCNQRGRLHLDQLDVGMPAKDDLSDAHGVYLLDNYGQSIWLWVGGQAPQADALSAMGN 341
               .|:|...::|...:.|.....|...||....|.||||..|..|::|.|.::...:..:|:..
Mouse   252 ---VRLYHVCEKGTDLVVQELATRPLTQDLLQEDGCYLLDQGGFKIYMWQGRKSSPQEKKAALSR 313

  Fly   342 GRAFVKKKKYPDNTLVVRVLEGHEPVEFKRLFANWLNVWQENTRGHKPVSTKF--GKLDAHSLCE 404
            ...|::.|.||:.|.|..|.:|.|...|::||.:|.   :|..|...|..:|.  |.|:...|..
Mouse   314 AVGFIQAKGYPNYTNVEVVNDGAESTAFQQLFWSWS---KELDRKKHPEKSKLVQGNLEVGKLHT 375

  Fly   405 RPKMAADTQLVDDGRGERVIYRVFGDQVQEVPISKTVVFTTNASFVVKYSVQCATVVPADLASVG 469
            :|::||..::||||.|:..::.:...|.|.|.........:...::|.|:.|          .:|
Mouse   376 QPELAAQLRMVDDGSGKVEVWYIQDLQRQPVHPKYYGQLCSGNCYLVLYTYQ----------KLG 430

  Fly   470 -IKTIIYQWNGSEASVESISRADKFAKASFDGLKEPGMFVQ--LYEFDEPPHFLQIFEGKLIIRR 531
             ::.::|.|.|.:::||. ::|...:....| |...|...|  :....||||||.||:|:|::.:
Mouse   431 CVQYLLYLWQGHQSTVED-TKALNCSAEELD-LMHQGALAQGHVTMGSEPPHFLAIFQGRLVVFQ 493

  Fly   532 GQRTEMPYNGNSNALLDTFLLKVYGDASYNAKAVE-ETHLSSISSKDCYVIKTNHV-WVWCGQSS 594
            |....   .|....:.||.|..|.|..|:|.:.:| ....||::|.|.:.:.|:|| ::|.|:..
Mouse   494 GNAGN---KGERPPVSDTRLFHVQGTESHNTRTMEVPARASSLTSGDVFFLITSHVCYLWFGKGC 555

  Fly   595 TGDAREMAKAVGALMGENS--LVLEGKESKEFWQSVAMYFNQTLVINGNGNSCSSSTSSSSGAGS 657
            .||.||||:.|.::...|:  .||||:|...||:::
Mouse   556 HGDQREMARTVVSVFPGNNKETVLEGQEPLYFWEAL----------------------------- 591

  Fly   658 MCNGSSNGGNISPTLSNNCYLNTSVPSKPRPPVQLFLVWWQQSSLRYE-----------EILGFD 711
                   ||            ....||..|.|.:   ||..|..| :|           |:|.|.
Mouse   592 -------GG------------RAPYPSNKRLPEE---VWSIQPRL-FECSSHAGCLVLTEVLFFG 633

  Fly   712 QQDLSSDCTYILDT----GSLT--YVWLGSQAPNQERYTAIA--QSYVQNAPFGRRSATALAVVR 768
            |:||......:|||    .|:.  ::||| :|..:.:..|:|  ..|::..|..|..||.:.||:
Mouse   634 QEDLDKYDIMLLDTCQEASSVAQIFLWLG-EAAGEWKKEAVAWGLEYLRTHPAERSLATPIFVVK 697

  Fly   769 QFQEPNVFKGFFESWQNDYGKNFHSYEKMRKDLGNKVTSNCCFASEGSALI----LNNRQKD--- 826
            |..||..|.|:|.:|......|..|||:|   :||.:...... ||.:|.:    |..|..|
Mouse   698 QGHEPATFTGWFVTWDPYKWMNSQSYEEM---VGNSLGPGSAI-SEMTAEVHNFQLTPRLSDNKA 758

  Fly   827 -------FDGHKKYPLT----------------------------------VLIQEMDMLPPDIN 850
                   |.|.:..|..                                  ::.|.::.|||.::
Mouse   759 GHPALQAFKGSQDSPENELGLDLRVDGANPSMNHTSSCSDSMVNGSLPRERLMHQALEDLPPGVD 823

  Fly   851 PLKREVHLTHDDFVSVFNMSFYEFDELPKWKKMELKKQFKLF 892
            |.::|.:|:..||..:|..|..||..:.|||:.:.||:...|
Mouse   824 PARKEFYLSDSDFQDIFGKSKEEFYSMAKWKQQQAKKKLGFF 865

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
qua	NP_001246066.1	ADF_gelsolin	26..147	CDD:301701	34/112 (30%)
		gelsolin_like	164..254	CDD:200436	22/98 (22%)
		gelsolin_S3_like	276..375	CDD:200448	30/98 (31%)
		GEL	424..526	CDD:214590	25/104 (24%)
		ADF_gelsolin	551..625	CDD:301701	28/77 (36%)
		gelsolin_like	689..780	CDD:200436	34/109 (31%)
		VHP	857..892	CDD:128458	12/34 (35%)
Vill	XP_006512122.1	ADF_gelsolin	16..121	CDD:387665	36/118 (31%)
		gelsolin_S2_like	136..229	CDD:200445	22/102 (22%)
		gelsolin_S3_like	249..345	CDD:200448	28/98 (29%)
		gelsolin_S4_like	385..485	CDD:200449	28/111 (25%)
		gelsolin_S5_like	508..596	CDD:200444	33/135 (24%)
		gelsolin_S6_like	611..713	CDD:200447	32/103 (31%)
		VHP	830..>850	CDD:366982	7/19 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1376537at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100298
Panther	1	1.100	-	-	O	PTHR11977
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.780