DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment qua and Vil1

DIOPT Version :9

Sequence 1:	NP_001246066.1	Gene:	qua / 35058	FlyBaseID:	FBgn0003187	Length:	892	Species:	Drosophila melanogaster
Sequence 2:	NP_033535.2	Gene:	Vil1 / 22349	MGIID:	98930	Length:	827	Species:	Mus musculus

Alignment Length:	910	Identity:	234/910 - (25%)
Similarity:	398/910 - (43%)	Gaps:	158/910 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 IWKIDEDRLEAVQRSHYGTFYDSCAYIIYAASLSGHYANHETITREQKPNVSLERYIHYWLGKNV 102
            ||:|:..::..|..|.:|:|:|...|::.|.        |:|       :.:|...||||:|::.
Mouse    21 IWRIEAMQMVPVPSSTFGSFFDGDCYVVLAI--------HKT-------SSTLSYDIHYWIGQDS 70

  Fly   103 SEQNRSNVVHKIQELDSYLGNISSIYRETQNLESARFLSYFKKGYEFRFSVRSGALISAPQR--- 164
            |:..:........::|.||...:..:||.|..||..|.||||:|    ..:|.|.:.|..:.
Mouse    71 SQDEQGAAAIYTTQMDDYLKGRAVQHREVQGNESETFRSYFKQG----LVIRKGGVASGMKHVET 131

  Fly   165 -----PRLFQLYARKWLRSIEVATIDWSHFNSDYVMVLQTDNLTYVWIGRSSSGIERRSALDWVQ 224
                 .||..:..::.:.:.|| .:.|..||...|.:|....|...|.|..|:.:||...:...:
Mouse   132 NSCDVQRLLHVKGKRNVLAGEV-EMSWKSFNRGDVFLLDLGKLIIQWNGPESNRMERLRGMALAK 195

  Fly   225 ----KHCSGSPITIVDDGYEQAMSQEHKELWNTMLPLKKRMVCQASQLVSEYADYNSNKFRIYKC 285
                :...|.....|.||.::..|.:...:.|.:|..:|.:....|..|.|.|...:.|. .:..
Mouse   196 EIRDQERGGRTYVGVVDGEKEGDSPQLMAIMNHVLGPRKELKAAISDSVVEPAAKAALKL-YHVS 259

  Fly   286 NQRGRLHLDQLDVGMPAKDDLSDAHGVYLLDNYGQSIWLWVGGQAPQADALSAMGNGRAFVKKKK 350
            :..|:|.:.:: ...|...||......|:||..|..|::|.|..|...:...||.....|:|.|:
Mouse   260 DSEGKLVVREV-ATRPLTQDLLKHEDCYILDQGGLKIFVWKGKNANAQERSGAMSQALNFIKAKQ 323

  Fly   351 YPDNTLVVRVLEGHEPVEFKRLFANWL------NVWQENTRGH--KPVSTKFGKLDAHSLCERPK 407
            ||.:|.|....:|.|...|::||..|.      .:.:.:|.|.  |....||..|..|   .:|:
Mouse   324 YPPSTQVEVQNDGAESPIFQQLFQKWTVPNRTSGLGKTHTVGSVAKVEQVKFDALTMH---VQPQ 385

  Fly   408 MAADTQLVDDGRGERVIYRVFGDQVQEVPI-SKTVVFTTNASFVVKYSVQCATVVPADLASVGIK 471
            :||..::||||.||..::|:  :.::.||: ||.:     ..|   |...|..::...|......
Mouse   386 VAAQQKMVDDGSGEVQVWRI--EDLELVPVESKWL-----GHF---YGGDCYLLLYTYLIGEKQH 440

  Fly   472 TIIYQWNGSEASVESISRADKFAKASFDGL-------KEPGMFVQLYEFDEPPHFLQIFEGKLII 529
            .::|.|.||:||      .|:.|.:::..:       .|| :.:::....||||.:.||:|::::
Mouse   441 YLLYIWQGSQAS------QDEIAASAYQAVLLDQKYNDEP-VQIRVTMGKEPPHLMSIFKGRMVV 498

  Fly   530 RRGQRTEMPYNGNSNALLDTFLLKVYGDASYNAKAVEET-HLSSISSKDCYVIKT-NHVWVWCGQ 592
            .:|..:.   ..|...:..|.|.:|.|..:.|.||.|.| ..:|::|.|.:::|| :..::|||:
Mouse   499 YQGGTSR---KNNLEPVPSTRLFQVRGTNADNTKAFEVTARATSLNSNDVFILKTPSCCYLWCGK 560

  Fly   593 SSTGDAREMAKAVGALMG--ENSLVLEGKESKEFWQSV---AMYFN------QTLVINGNGNSCS 646
            ..:||.|||||.|...:.  |..:|:||:|...||.::   |.|.|      :..||......||
Mouse   561 GCSGDEREMAKMVADTISRTEKQVVVEGQEPANFWMALGGKAPYANTKRLQEENQVITPRLFECS 625

  Fly   647 SSTSSSSGAGSMCNGSSNGGNISPTLSNNCYLNTSVPSKPRPPVQLFLVWWQQSSLRYEEILGFD 711
            :.|..                         :|.|                         ||..|:
Mouse   626 NQTGR-------------------------FLAT-------------------------EIFDFN 640

  Fly   712 QQDLSSDCTYILDTGSLTYVWLGSQAPNQERYTA--IAQSYVQNAPFGRRSATALAVVRQFQEPN 774
            |.||..:..::||.....:.|:|..|..:|:..|  ..|.|::..|..|...|.:.||:|..||.
Mouse   641 QDDLEEEDVFLLDVWDQVFFWIGKHANEEEKKAAATTVQEYLKTHPGNRDLETPIIVVKQGHEPP 705

  Fly   775 VFKGFFESWQNDYGKNFHSYEKMRKDLGNKVTSNCCFASEGSAL---ILNNRQKDFDGHKK---- 832
            .|.|:|.:|......|..||:.::.:|||        :.:.|.:   :::.:...|..:..
Mouse   706 TFTGWFLAWDPFKWSNTKSYDDLKAELGN--------SGDWSQIADEVMSPKVDVFTANTSLSSG 762

  Fly   833 ----YPLTVLI-QEMDMLPPDINPLKREVHLTHDDFVSVFNMSFYEFDELPKWKKMELKKQFKLF 892
                :||..|: :.::.||..::|.::|.||:.:||.....|:...|..||:||:..:||:..||
Mouse   763 PLPTFPLEQLVNKSVEDLPEGVDPSRKEEHLSTEDFTRALGMTPAAFSALPRWKQQNIKKEKGLF 827

Fly 893 892
Mouse 828 827

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
qua	NP_001246066.1	ADF_gelsolin	26..147	CDD:301701	32/108 (30%)
		gelsolin_like	164..254	CDD:200436	21/101 (21%)
		gelsolin_S3_like	276..375	CDD:200448	28/98 (29%)
		GEL	424..526	CDD:214590	25/109 (23%)
		ADF_gelsolin	551..625	CDD:301701	29/77 (38%)
		gelsolin_like	689..780	CDD:200436	25/92 (27%)
		VHP	857..892	CDD:128458	12/34 (35%)
Vil1	NP_033535.2	Core	1..734		209/807 (26%)
		Necessary for homodimerization. /evidence=ECO:0000250	1..126		36/123 (29%)
		gelsolin_S1_like	17..121	CDD:200446	34/118 (29%)
		LPA/PIP2-binding site 1. /evidence=ECO:0000250	112..119		2/10 (20%)
		gelsolin_S2_like	136..225	CDD:200445	20/89 (22%)
		LPA/PIP2-binding site 2. /evidence=ECO:0000250	138..146		2/7 (29%)
		gelsolin_S3_like	250..348	CDD:200448	28/99 (28%)
		gelsolin_S4_like	392..492	CDD:200449	29/116 (25%)
		gelsolin_S5_like	513..603	CDD:200444	32/89 (36%)
		gelsolin_S6_like	619..715	CDD:200447	31/145 (21%)
		Headpiece	735..827		21/91 (23%)
		VHP	793..827	CDD:280388	11/33 (33%)
		LPA/PIP2-binding site 3. /evidence=ECO:0000250	816..824		3/7 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100298
Panther	1	1.100	-	-	O	PTHR11977
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.770