DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment qua and Scin

DIOPT Version :9

Sequence 1:NP_001246066.1 Gene:qua / 35058 FlyBaseID:FBgn0003187 Length:892 Species:Drosophila melanogaster
Sequence 2:NP_001139668.1 Gene:Scin / 20259 MGIID:1306794 Length:715 Species:Mus musculus


Alignment Length:806 Identity:194/806 - (24%)
Similarity:322/806 - (39%) Gaps:172/806 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    38 IWKIDEDRLEAVQRSHYGTFYDSCAYIIYAASLSGHYANHETITREQKPNVSLERYIHYWLGKNV 102
            :|::::..|..|.:..||.||...||::.          |.|     |.:......:|:||||..
Mouse    21 VWRVEKLELVPVPQGAYGDFYVGDAYLVL----------HTT-----KSSRGFSYRLHFWLGKEC 70

  Fly   103 SEQNRSNVVHKIQELDSYLGNISSIYRETQNLESARFLSYFKKGYEFRF-SVRSG---ALISAPQ 163
            |:...:.......::|.|||......||.|..||..|:.|||.|.:::. .|.||   .|.:...
Mouse    71 SQDESTAAAIFTVQMDDYLGGKPVQSRELQGYESTDFVGYFKGGLKYKAGGVASGLNHVLTNDLT 135

  Fly   164 RPRLFQLYARKWLRSIEVATIDWSHFNSDYVMVLQTDNLTYVWIGRSSSGIERRSALDWV----- 223
            ..||..:..|:.:|:.|| .:.|..||.....::......|.|.|.|.:..||..|....     
Mouse   136 AKRLLHVKGRRVVRATEV-PLSWESFNKGDCFIIDLGTEIYQWCGSSCNKYERLKASQVAIGIRD 199

  Fly   224 QKHCSGSPITIVDDGYEQAMSQEHKELWNTM-----LP-----------------LKKRMVCQAS 266
            .:....|.:.:|::|      .|..||...:     ||                 .|..||..||
Mouse   200 NERKGRSQLIVVEEG------SEPSELMKVLGRKPELPDGDNDDDVVADISNRKMAKLYMVSDAS 258

  Fly   267 -----QLVSEYADYNSNKFRIYKCNQRGRLHLDQLDVGMPAKDDLSDAHGVYLLDN-YGQSIWLW 325
                 .||:|     .|.|                .:||...::      .::||: ..:.|::|
Mouse   259 GSMKVTLVAE-----ENPF----------------SMGMLLSEE------CFILDHGAAKQIFVW 296

  Fly   326 VGGQAPQADALSAMGNGRAFVKKKKYPDNTLVVRVLEGHEPVEFKRLFANWLNVWQENTRGHKPV 390
            .|..|...:..:||.....|::|.||..||.:..:.||.|...||:.|.:|.:..|.:..|...:
Mouse   297 KGKNANPQERKTAMKTAEEFLQKMKYSTNTQIQVLPEGGETPIFKQFFKDWKDKDQSDGFGKVYI 361

  Fly   391 STKFGKL-----DAHSLCERPKMAADTQLVDDGRGERVIYRVFGDQVQEVPISKTVVFTTNASFV 450
            :.|..::     ||..|...|:|||...:||||.|...|:||......::..|....|.....::
Mouse   362 TEKVAQIKQIPFDASKLHSSPQMAAQHNMVDDGSGGVEIWRVENSGRVQIDPSSYGEFYGGDCYI 426

  Fly   451 VKYSVQCATVVPADLASVGIKTIIYQWNGSEASVESISRADKFAKASFD-GLKEPGMFVQLYEFD 514
            :.|:....             .|||.|.|:.|:.:.::.: .|.....| .|....:.|::.:..
Mouse   427 ILYTYPRG-------------QIIYTWQGANATRDELTMS-AFLTVQLDRSLGGQAVQVRVSQGK 477

  Fly   515 EPPHFLQIFEGKLII--------RRGQRTEMPYNGNSNALLDTFLLKVYGDASYNAKAVE-ETHL 570
            ||.|.|.:|:.|.:|        :.||....|          |.|.:|..:.:...:.|| :...
Mouse   478 EPAHLLSLFKDKPLIIYKNGTSKKEGQAPAPP----------TRLFQVRRNLASITRIVEVDVDA 532

  Fly   571 SSISSKDCYVIK--TNHVWVWCGQSSTGDAREMAKAVG-ALMGENSLVLEGKESKEFWQSVAMYF 632
            :|::|.|.:|:|  .|:.::|.|:.::.:..:.|:.|. .|..:.|.:.||||.:|||.|     
Mouse   533 NSLNSNDTFVLKLPRNNGFIWIGKGASQEEEKGAEYVADVLKCKASRIQEGKEPEEFWNS----- 592

  Fly   633 NQTLVINGNGNSCSSSTSSSSGAGSMCNGSSNGGNISPTLSNNCYLNTSVPSKPRPPVQLFLVWW 697
                 :.|.|:.                      ..||.|...        ::..|| :|:....
Mouse   593 -----LGGRGDY----------------------QTSPLLETR--------AEDHPP-RLYGCSN 621

  Fly   698 QQSSLRYEEILG-FDQQDLSSDCTYILDTGSLTYVWLGSQAPNQERYTAI--AQSYVQNAPFGRR 759
            :......||:.| |.|.||:.|...:||.....::|:|..|...|:..::  |:.|::..|.||.
Mouse   622 KTGRFIIEEVPGEFTQDDLAEDDVMLLDAWEQIFIWIGKDANEVEKKESVKSAKMYLETDPSGRD 686

  Fly   760 SATALAVVRQFQEPNVFKGFFESWQN 785
            ..|.:.:::|..||..|.|:|..|.:
Mouse   687 KRTPIVIIKQGHEPPTFTGWFLGWDS 712

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
quaNP_001246066.1 ADF_gelsolin 26..147 CDD:301701 31/108 (29%)
gelsolin_like 164..254 CDD:200436 22/94 (23%)
gelsolin_S3_like 276..375 CDD:200448 24/99 (24%)
GEL 424..526 CDD:214590 21/102 (21%)
ADF_gelsolin 551..625 CDD:301701 21/77 (27%)
gelsolin_like 689..780 CDD:200436 27/93 (29%)
VHP 857..892 CDD:128458
ScinNP_001139668.1 Actin-severing. /evidence=ECO:0000255 1..363 95/390 (24%)
gelsolin_S1_like 10..121 CDD:200446 32/114 (28%)
Polyphosphoinositide binding. /evidence=ECO:0000250 112..119 2/6 (33%)
gelsolin_S2_like 136..225 CDD:200445 22/95 (23%)
Polyphosphoinositide binding. /evidence=ECO:0000250 138..146 2/7 (29%)
gelsolin_S3_like 246..346 CDD:200448 32/126 (25%)
Ca(2+)-dependent actin binding 364..715 99/414 (24%)
gelsolin_S4_like 390..486 CDD:200449 25/109 (23%)
gelsolin_S5_like 508..598 CDD:200444 27/109 (25%)
gelsolin_S6_like 613..711 CDD:200447 29/98 (30%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0443
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1376537at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100298
Panther 1 1.100 - - O PTHR11977
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
65.820

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