DRSC/TRiP Functional Genomics Resources

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Protein Alignment qua and Flii

DIOPT Version :10

Sequence 1:NP_001246066.1 Gene:qua / 35058 FlyBaseID:FBgn0003187 Length:892 Species:Drosophila melanogaster
Sequence 2:NP_071292.1 Gene:Flii / 14248 MGIID:1342286 Length:1271 Species:Mus musculus


Alignment Length:879 Identity:197/879 - (22%)
Similarity:325/879 - (36%) Gaps:251/879 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    38 IWKIDEDRLEAVQRSHYGTFYDSCAYIIYAASL--SGHYANHETITREQKPNVSLERYIHYWLGK 100
            ||:|:......|:.:.:|.||::..||:....|  ||                ||...|:||:|.
Mouse   503 IWQIENFVPVLVEEAFHGKFYEADCYIVLKTFLDDSG----------------SLNWEIYYWIGG 551

  Fly   101 NVS-EQNRSNVVHKIQELDSYLGNISSIYRETQNLESARFL-------SYFKKGYEFRF-SVRSG 156
            ..: ::...:.:|.: .|.:|||......||....||..||       ||.:.|....| :|...
Mouse   552 EATLDKKACSAIHAV-NLRNYLGAECRTVREEMGDESEEFLQVFDNDISYIEGGTASGFYTVEDT 615

  Fly   157 ALISAPQRPRLFQLYARKWLRSIEVATIDWSHFNSDYVMVLQTDNLTYVWIGRS---SSGIERRS 218
            ..::     |::::|.:|.:: :|...:..|..:..:|.:|......|||.|..   |:..:.|.
Mouse   616 HYVT-----RMYRVYGKKNIK-LEPVPLKGSSLDPRFVFLLDQGLDIYVWRGAQATLSNTTKARL 674

  Fly   219 ALDWVQKH--CSGSPITIVDDGYEQAMSQEHKELWNTMLPLKKRMVCQASQLVSEYADYNSNKF- 280
            ..:.:.|:  ...:.||::..|      ||....|:.:           ....||..::..:.| 
Mouse   675 FAEKINKNERKGKAEITLLVQG------QEPPGFWDVL-----------GGEPSEIKNHVPDDFW 722

  Fly   281 ----RIYKCN-QRGRLHLDQLDV----------------GMPAKDDLSDAHGVYLLDNYGQSIWL 324
                ::||.. ..|.|.|.|::.                ||.....|.|...||:||.: ..:::
Mouse   723 PPQPKLYKVGLGLGYLELPQINYKLSVEHKKRPKVELMPGMRLLQSLLDTRCVYILDCW-SDVFI 786

  Fly   325 WVGGQAPQADALSAMGNGRAFVKKKKYPDNTLVVRVLEGHEPVEFKRLFANWLNVWQ-ENTRGHK 388
            |:|.::|:....:|:..|:........|.:|:|.|.|||.|...||..|.||.:|.. :.||..:
Mouse   787 WLGRKSPRLVRAAALKLGQELCGMLHRPRHTVVSRSLEGTEAQVFKAKFKNWDDVLTVDYTRNAE 851

  Fly   389 PVSTKFG-----------------KLDAHSLCERPKM--AADTQLVD------DGRGERVIYRVF 428
            .|....|                 .|.|..|..:|.|  |...||::      ||....|:.   
Mouse   852 AVLQGQGLSGKVKRDTEKTDQMKADLTALFLPRQPPMPLAEAEQLMEEWNEDLDGMEGFVLE--- 913

  Fly   429 GDQVQEVPISKTVVFTTNASFV--------VKYSVQCATVVPADLASV----------------- 468
            |.:...:|..:...|.|...:|        |:|..:..|......||.                 
Mouse   914 GRKFTRLPEEEFGHFYTQDCYVFLCRYWVPVEYEEEEKTEDKEGKASAEAREGEEAAAEAEEKQP 978

  Fly   469 --GIKTIIYQWNGSEAS-----VESISRADKFAKASFDGLKEPGMFVQLYEFDEPPHFLQIFEGK 526
              ..:.|:|.|.|.|||     ..:.|...|| ::.|.|..|   .|::.:..|.|.||..|:.|
Mouse   979 EEDFQCIVYFWQGREASNMGWLTFTFSLQKKF-ESLFPGKLE---VVRMTQQQENPKFLSHFKRK 1039

  Fly   527 LIIRRGQR-----TEMP--YNGNSN-ALLDTFLLKVYGDASYNAKAVEETHLSSISSKDCYVIKT 583
            .||.||:|     |..|  |...:| :.|.|..:::..|:|.            ::|:.|:::|.
Mouse  1040 FIIHRGKRKVTQGTLQPTLYQIRTNGSALCTRCIQINTDSSL------------LNSEFCFILKV 1092

  Fly   584 --------NHVWVWCGQSSTGDAREMAKAVGALMGENS----LVLEGKESKE-FWQSV------- 628
                    ..|:.|.|::|..|..::|:.:...|.:.|    ::.||:|.:. ||..:       
Mouse  1093 PFESEDNQGIVYAWVGRASDPDEAKLAEDILNTMFDASYSKQVINEGEEPENFFWVGIGAQKPYD 1157

  Fly   629 --AMYFNQTLVINGNGNSCSSSTSSSSGAGSMCNGSSNGGNISPTLSNNCYLNTSVPSKPRPPVQ 691
              |.|...|.:..     ||:..                |..:.|                    
Mouse  1158 DDAEYMKHTRLFR-----CSNEK----------------GYFAVT-------------------- 1181

  Fly   692 LFLVWWQQSSLRYEEILGFDQQDLSSDCTYILDTGSLTYVWLGSQAPNQERYTAI--AQSYVQNA 754
                         |:...|.|.||:.|...:||.|...|:|:|:|....|...::  .|.|:|:.
Mouse  1182 -------------EKCSDFCQDDLADDDIMLLDNGQEVYMWVGTQTSQVEIKLSLKACQVYIQHT 1233

  Fly   755 PFGRRS-----ATALAVVRQFQEPNVFKGFFESW 783
                ||     ...|.:||:..|...|...|.:|
Mouse  1234 ----RSKEHERPRRLRLVRKGNEQRAFTRCFHAW 1263

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
quaNP_001246066.1 ADF_gelsolin 26..147 CDD:472830 31/118 (26%)
gelsolin_like 164..254 CDD:200436 20/94 (21%)
gelsolin_S3_like 276..375 CDD:200448 31/120 (26%)
GEL 424..526 CDD:214590 29/133 (22%)
ADF_gelsolin 551..625 CDD:472830 16/86 (19%)
gelsolin_like 689..780 CDD:200436 24/97 (25%)
VHP 857..892 CDD:128458
FliiNP_071292.1 Interaction with LRRFIP1 and LRRFIP2. /evidence=ECO:0000250 1..427
leucine-rich repeat 10..34 CDD:275380
leucine-rich repeat 35..57 CDD:275380
LRR 38..>374 CDD:443914
leucine-rich repeat 58..80 CDD:275380
leucine-rich repeat 106..128 CDD:275380
leucine-rich repeat 129..152 CDD:275380
leucine-rich repeat 153..175 CDD:275380
leucine-rich repeat 176..199 CDD:275380
leucine-rich repeat 200..224 CDD:275380
leucine-rich repeat 225..247 CDD:275380
leucine-rich repeat 248..270 CDD:275380
leucine-rich repeat 271..318 CDD:275380
leucine-rich repeat 319..341 CDD:275380
gelsolin_S1_like 492..604 CDD:200446 31/117 (26%)
Interaction with ACTL6A. /evidence=ECO:0000250 495..827 83/364 (23%)
gelsolin_like 619..703 CDD:200436 19/95 (20%)
gelsolin_S3_like 723..837 CDD:200448 30/114 (26%)
Gelsolin-like 3. /evidence=ECO:0000255 759..831 21/72 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 951..977 3/25 (12%)
gelsolin_like <981..1036 CDD:200436 18/58 (31%)
gelsolin_S5_like 1055..1154 CDD:200444 23/110 (21%)
gelsolin_S6_like 1165..1264 CDD:200447 31/157 (20%)
Gelsolin-like 4. /evidence=ECO:0000255 1183..1256 22/76 (29%)
Blue background indicates that the domain is not in the aligned region.

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