Protein Alignment qua and AVIL

DIOPT Version :10

• Sequence 1: NP_001246066.1
• Gene: qua / 35058
• FlyBaseID: FBgn0003187
• Length: 892
• Species: Drosophila melanogaster
• Sequence 2: XP_047284066.1
• Gene: AVIL / 10677
• HGNCID: 14188
• Length: 863
• Species: Homo sapiens
• Alignment Length: 911
• Identity: 253/911 - (27%)
• Similarity: 426/911 - (46%)
• Gaps: 121/911 - (13%)

  Fly    38 IWKIDEDRLEAVQRSHYGTFYDSCAYIIYA----ASLSGHYANHETITREQKPNVSLERYIHYWL 98
            :|:|::..|..|..|.:|.||:...|:|.:    |||                   |.:.||:|:
Human    18 VWRIEKMELALVPVSAHGNFYEGDCYVILSTRRVASL-------------------LSQDIHFWI 63

  Fly    99 GKNVSEQNRSNVVHKIQELDSYLGNISSIYRETQNLESARFLSYFKKGYEFRFSVRSGALISAPQ 163
            ||:.|:..:|.......:||.|||.....:||.|..||..|..|||:|..:    :.|.:.|..:
Human    64 GKDSSQDEQSCAAIYTTQLDDYLGGSPVQHREVQYHESDTFRGYFKQGIIY----KQGGVASGMK 124

  Fly   164 R--------PRLFQLYARKWLRSIEVATIDWSHFNSDYVMVLQTDNLTYVWIGRSSSGIERRSAL 220
            .        .||..:..::.:|:.|| .:.|..||...|.:|....:...|.|..|:..||..|:
Human   125 HVETNTYDVKRLLHVKGKRNIRATEV-EMSWDSFNRGDVFLLDLGKVIIQWNGPESNSGERLKAM 188

  Fly   221 ----DWVQKHCSG-SPITIVDDGYEQAMSQEHKELWNTMLPLKKRMVCQASQLVSEYADY-NSNK 279
                |...:...| :.|.:::...|.|..:..|.|.:|   |.:|.:.:.: :..|..|. ..:.
Human   189 LLAKDIRDRERGGRAKIGVIEGDKEAASPELMKVLQDT---LGRRSIIKPT-VPDEIIDQKQKST 249

  Fly   280 FRIYK-CNQRGRLHLDQLDVGMPAKDDLSDAHGVYLLDNYGQSIWLWVGGQAPQADALSAMGNGR 343
            ..:|. .:..|:|.:.:: ...|...||.:....|:||..|..|::|.|..|.:|:..:||....
Human   250 IMLYHISDSAGQLAVTEV-ATRPLVQDLLNHDDCYILDQSGTKIYVWKGKGATKAEKQAAMSKAL 313

  Fly   344 AFVKKKKYPDNTLVVRVLEGHEPVEFKRLFANWLNVWQENTRG-------HKPVSTKFGKLDAHS 401
            .|:|.|.||.:|.|..|.:|.|...||:||..| :| ::.|.|       .|.......|.|...
Human   314 GFIKMKSYPSSTNVETVNDGAESAMFKQLFQKW-SV-KDQTMGLGKTFSIGKIAKVFQDKFDVTL 376

  Fly   402 LCERPKMAADTQLVDDGRGERVIYRVFGDQVQEVPISKTVVFTTNASFVVKYSVQCATVVPADLA 466
            |..:|::||..::||||.|:..::|:  :.::.||:.    :.....|   |...|..|:.....
Human   377 LHTKPEVAAQERMVDDGNGKVEVWRI--ENLELVPVE----YQWYGFF---YGGDCYLVLYTYEV 432

  Fly   467 SVGIKTIIYQWNGSEASVESISRADKFAKASFDGLKEPGMF------VQLYEFDEPPHFLQIFEG 525
            :.....|:|.|.|..||      .|:.|.:::..::....|      |::....||.||:.||:|
Human   433 NGKPHHILYIWQGRHAS------QDELAASAYQAVEVDRQFDGAAVQVRVRMGTEPRHFMAIFKG 491

  Fly   526 KLIIRRGQRTEMPYNGNSNALLDTFLLKVYGDASYNAKAVE-ETHLSSISSKDCYVIKT--NHVW 587
            ||:|..|..:.   .||:.......|.:::|:...|.|||| ....||::|.|.::::|  .| :
Human   492 KLVIFEGGTSR---KGNAEPDPPVRLFQIHGNDKSNTKAVEVPAFASSLNSNDVFLLRTQAEH-Y 552

  Fly   588 VWCGQSSTGDAREMAKAVGALM--GENSLVLEGKESKEFWQSVAMYFNQTLVINGN--GNSCSSS 648
            :|.|:.|:||.|.|||.:.:|:  |..:.|.||:|..|||..:.   .:|...|..  ||:.|.|
Human   553 LWYGKGSSGDERAMAKELASLLCDGSENTVAEGQEPAEFWDLLG---GKTPYANDKRYGNTASPS 614

  Fly   649 TSSSSGAGSM-CNGSSNG------GNISPTLSNNCYLNTSVPSKPRPPVQ--LFLVWWQQSSLRY 704
            :.....|..: |..:...      .::.|.....|.|...:..     ||  ||....:......
Human   615 SGLPLPARLVNCTKAKTSVLKTFLSSLMPLNGLYCRLQQEILD-----VQSRLFECSNKTGQFVV 674

  Fly   705 EEILGFDQQDLSSDCTYILDTGSLTYVWLGSQAPNQERYTAI--AQSYVQNAPFGRRSATALAVV 767
            .||..|.|.||:.....:|||....::|:|::|...|:.:|:  ||.|:...|.||...|.:.::
Human   675 TEITDFTQDDLNPTDVMLLDTWDQVFLWIGAEANATEKESALATAQQYLHTHPSGRDPDTPILII 739

  Fly   768 RQFQEPNVFKGFFESWQNDYGKNFHSYEKMRKDLGN-----KVTSNCCFASEGSALILNNRQKDF 827
            :|..||.:|.|:|.:|..:......:||:::::||:     ::|::    .:.:.|.||:...:
Human   740 KQGFEPPIFTGWFLAWDPNIWSAGKTYEQLKEELGDAAAIMRITAD----MKNATLSLNSNDSE- 799

  Fly   828 DGHKKYPLTVLIQEMDM-LPPDINPLKREVHLTHDDFVSVFNMSFYEFDELPKWKKMELKKQFKL 891
              .|.||:.||::..:. ||.|:||.|:|.:|:..||||||.::..:|..||.||::::||:..|
Human   800 --PKYYPIAVLLKNQNQELPEDVNPAKKENYLSEQDFVSVFGITRGQFAALPGWKQLQMKKEKGL 862

  Fly   892 F 892
            |
Human   863 F 863

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
qua	NP_001246066.1	ADF_gelsolin	26..147	CDD:472830	35/112 (31%)
		gelsolin_like	164..254	CDD:200436	23/102 (23%)
		gelsolin_S3_like	276..375	CDD:200448	31/99 (31%)
		GEL	424..526	CDD:214590	23/107 (21%)
		ADF_gelsolin	551..625	CDD:472830	29/78 (37%)
		gelsolin_like	689..780	CDD:200436	30/94 (32%)
		VHP	857..892	CDD:128458	14/34 (41%)
AVIL	XP_047284066.1	gelsolin_S1_like	7..118	CDD:200446	36/122 (30%)
		gelsolin_S2_like	133..223	CDD:200445	22/90 (24%)
		gelsolin_S3_like	247..345	CDD:200448	31/98 (32%)
		gelsolin_S4_like	389..489	CDD:200449	26/114 (23%)
		gelsolin_S5_like	510..600	CDD:200444	31/93 (33%)
		gelsolin_S6_like	659..756	CDD:200447	30/96 (31%)
		VHP	828..863	CDD:460493	14/34 (41%)