DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment qua and AVIL

DIOPT Version :9

Sequence 1:	NP_001246066.1	Gene:	qua / 35058	FlyBaseID:	FBgn0003187	Length:	892	Species:	Drosophila melanogaster
Sequence 2:	NP_006567.3	Gene:	AVIL / 10677	HGNCID:	14188	Length:	819	Species:	Homo sapiens

Alignment Length:	909	Identity:	246/909 - (27%)
Similarity:	414/909 - (45%)	Gaps:	161/909 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 IWKIDEDRLEAVQRSHYGTFYDSCAYIIYA----ASLSGHYANHETITREQKPNVSLERYIHYWL 98
            :|:|::..|..|..|.:|.||:...|:|.:    |||                   |.:.||:|:
Human    18 VWRIEKMELALVPVSAHGNFYEGDCYVILSTRRVASL-------------------LSQDIHFWI 63

  Fly    99 GKNVSEQNRSNVVHKIQELDSYLGNISSIYRETQNLESARFLSYFKKGYEFRFSVRSGALISAPQ 163
            ||:.|:..:|.......:||.|||.....:||.|..||..|..|||:|..:    :.|.:.|..:
Human    64 GKDSSQDEQSCAAIYTTQLDDYLGGSPVQHREVQYHESDTFRGYFKQGIIY----KQGGVASGMK 124

  Fly   164 R--------PRLFQLYARKWLRSIEVATIDWSHFNSDYVMVLQTDNLTYVWIGRSSSGIERRSAL 220
            .        .||..:..::.:|:.|| .:.|..||...|.:|....:...|.|..|:..||..|:
Human   125 HVETNTYDVKRLLHVKGKRNIRATEV-EMSWDSFNRGDVFLLDLGKVIIQWNGPESNSGERLKAM 188

  Fly   221 ----DWVQKHCSG-SPITIVDDGYEQAMSQEHKELWNTMLPLKKRMVCQASQLVSEYADY-NSNK 279
                |...:...| :.|.:::...|.|..:..|.|.:|   |.:|.:.:.: :..|..|. ..:.
Human   189 LLAKDIRDRERGGRAKIGVIEGDKEAASPELMKVLQDT---LGRRSIIKPT-VPDEIIDQKQKST 249

  Fly   280 FRIYK-CNQRGRLHLDQLDVGMPAKDDLSDAHGVYLLDNYGQSIWLWVGGQAPQADALSAMGNGR 343
            ..:|. .:..|:|.:.:: ...|...||.:....|:||..|..|::|.|..|.:|:..:||....
Human   250 IMLYHISDSAGQLAVTEV-ATRPLVQDLLNHDDCYILDQSGTKIYVWKGKGATKAEKQAAMSKAL 313

  Fly   344 AFVKKKKYPDNTLVVRVLEGHEPVEFKRLFANWLNVWQENTRG-------HKPVSTKFGKLDAHS 401
            .|:|.|.||.:|.|..|.:|.|...||:||..| :| ::.|.|       .|.......|.|...
Human   314 GFIKMKSYPSSTNVETVNDGAESAMFKQLFQKW-SV-KDQTMGLGKTFSIGKIAKVFQDKFDVTL 376

  Fly   402 LCERPKMAADTQLVDDGRGERVIYRVFGDQVQEVPISKTVVFTTNASFVVKYSVQCATVVPADLA 466
            |..:|::||..::||||.|:..::|:  :.::.||:.    :.....|   |...|..|:.....
Human   377 LHTKPEVAAQERMVDDGNGKVEVWRI--ENLELVPVE----YQWYGFF---YGGDCYLVLYTYEV 432

  Fly   467 SVGIKTIIYQWNGSEASVESISRADKFAKASFDGLKEPGMF------VQLYEFDEPPHFLQIFEG 525
            :.....|:|.|.|..||      .|:.|.:::..::....|      |::....||.||:.||:|
Human   433 NGKPHHILYIWQGRHAS------QDELAASAYQAVEVDRQFDGAAVQVRVRMGTEPRHFMAIFKG 491

  Fly   526 KLIIRRGQRTEMPYNGNSNALLDTFLLKVYGDASYNAKAVE-ETHLSSISSKDCYVIKT--NHVW 587
            ||:|..|..:.   .||:.......|.:::|:...|.|||| ....||::|.|.::::|  .| :
Human   492 KLVIFEGGTSR---KGNAEPDPPVRLFQIHGNDKSNTKAVEVPAFASSLNSNDVFLLRTQAEH-Y 552

  Fly   588 VWCGQSSTGDAREMAKAVGALM--GENSLVLEGKESKEFWQSV---AMYFN------QTLVINGN 641
            :|.|:.|:||.|.|||.:.:|:  |..:.|.||:|..|||..:   ..|.|      :.|.:...
Human   553 LWYGKGSSGDERAMAKELASLLCDGSENTVAEGQEPAEFWDLLGGKTPYANDKRLQQEILDVQSR 617

  Fly   642 GNSCSSSTSSSSGAGSMCNGSSNGGNISPTLSNNCYLNTSVPSKPRPPVQLFLVWWQQSSLRYEE 706
            ...||:.|..                                         |:|         .|
Human   618 LFECSNKTGQ-----------------------------------------FVV---------TE 632

  Fly   707 ILGFDQQDLSSDCTYILDTGSLTYVWLGSQAPNQERYTAI--AQSYVQNAPFGRRSATALAVVRQ 769
            |..|.|.||:.....:|||....::|:|::|...|:.:|:  ||.|:...|.||...|.:.:::|
Human   633 ITDFTQDDLNPTDVMLLDTWDQVFLWIGAEANATEKESALATAQQYLHTHPSGRDPDTPILIIKQ 697

  Fly   770 FQEPNVFKGFFESWQNDYGKNFHSYEKMRKDLGN-----KVTSNCCFASEGSALILNNRQKDFDG 829
            ..||.:|.|:|.:|..:......:||:::::||:     ::|::    .:.:.|.||:...:
Human   698 GFEPPIFTGWFLAWDPNIWSAGKTYEQLKEELGDAAAIMRITAD----MKNATLSLNSNDSE--- 755

  Fly   830 HKKYPLTVLIQEMDM-LPPDINPLKREVHLTHDDFVSVFNMSFYEFDELPKWKKMELKKQFKLF 892
            .|.||:.||::..:. ||.|:||.|:|.:|:..||||||.::..:|..||.||::::||:..||
Human   756 PKYYPIAVLLKNQNQELPEDVNPAKKENYLSEQDFVSVFGITRGQFAALPGWKQLQMKKEKGLF 819

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
qua	NP_001246066.1	ADF_gelsolin	26..147	CDD:301701	35/112 (31%)
		gelsolin_like	164..254	CDD:200436	23/102 (23%)
		gelsolin_S3_like	276..375	CDD:200448	31/99 (31%)
		GEL	424..526	CDD:214590	23/107 (21%)
		ADF_gelsolin	551..625	CDD:301701	29/78 (37%)
		gelsolin_like	689..780	CDD:200436	28/92 (30%)
		VHP	857..892	CDD:128458	14/34 (41%)
AVIL	NP_006567.3	Core. /evidence=ECO:0000250	1..731		213/812 (26%)
		gelsolin_S1_like	7..118	CDD:200446	36/122 (30%)
		Polyphosphoinositide binding. /evidence=ECO:0000250	109..116		2/10 (20%)
		gelsolin_S2_like	133..223	CDD:200445	22/90 (24%)
		Polyphosphoinositide binding. /evidence=ECO:0000250	135..143		2/7 (29%)
		gelsolin_S3_like	247..345	CDD:200448	31/98 (32%)
		gelsolin_S4_like	389..489	CDD:200449	26/114 (23%)
		gelsolin_S5_like	510..600	CDD:200444	31/90 (34%)
		gelsolin_S6_like	615..712	CDD:200447	32/146 (22%)
		Required for interaction with F-actin. /evidence=ECO:0000269\|PubMed:29058690	628..819		64/206 (31%)
		Headpiece. /evidence=ECO:0000250	731..819		30/94 (32%)
		VHP	784..819	CDD:128458	14/34 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1376537at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100298
Panther	1	1.100	-	-	O	PTHR11977
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	6	5.780