DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment qua and vil1

DIOPT Version :9

Sequence 1:	NP_001246066.1	Gene:	qua / 35058	FlyBaseID:	FBgn0003187	Length:	892	Species:	Drosophila melanogaster
Sequence 2:	NP_001096367.1	Gene:	vil1 / 100124960	XenbaseID:	XB-GENE-965127	Length:	824	Species:	Xenopus tropicalis

Alignment Length:	941	Identity:	245/941 - (26%)
Similarity:	404/941 - (42%)	Gaps:	182/941 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 IPDL--KVDATFRKVAKHAITFAIWKIDEDRLEAVQRSHYGTFYDSCAYIIYAASLSGHYANHET 79
            :|:|  ||..|..|...   ...||:::...|..|..:.||.|:|...|::.....:|:...::
Frog     1 MPELTEKVKKTLNKTTP---GLQIWRVESMNLVPVPENSYGNFFDGDCYVLLMTHKTGNNFTYD- 61

  Fly    80 ITREQKPNVSLERYIHYWLGKNVS-EQNRSNVVHKIQELDSYLGNISSIYRETQNLESARFLSYF 143
                          ||:|:|.:.| ::..:..::.|| :|.:||..:..:||.|..||..|..||
Frog    62 --------------IHFWVGNDSSMDEQGAAAIYTIQ-MDDHLGGAAIQHREVQGHESDTFKGYF 111

  Fly   144 KKGYEFRFSVRSGALISAPQR--------PRLFQLYARKWLRSIEVATIDWSHFNSDYVMVLQTD 200
            |.|..:    :||.:.|....        .||.....:|.:.:.|| .::||.||...|.:|...
Frog   112 KHGIIY----KSGGVASGMNHVETNTYNVKRLLHCKGKKNVLAGEV-PVEWSSFNVGDVFLLDLG 171

  Fly   201 NLTYVWIGRSSSGIER----RSALDWVQKHCSG-SPITIVDDGYEQAMSQ----------EHKEL 250
            .|...|.|..|:..||    ..|.|...:...| |.:.:|:...|:...|          |.||:
Frog   172 KLIIQWNGPESNKQERLRGMTLAKDIRDRERGGRSYVGVVEGDNEEQSPQLMAIMTYVLGERKEI 236

  Fly   251 WNTMLPLKKRMVCQASQLVSEYADYNSNKFRIYKCNQRGRLHLDQLDVGMPAKDDLSDAHGVYLL 315
            ...:          ..::|.:.|..:...|::  .:..|.|.:.:: ...|...||......|:|
Frog   237 RGAI----------PDEVVDQVAKTSIKLFQV--SDNSGNLMVQEV-ATQPLTQDLLKHDDCYIL 288

  Fly   316 DNYGQSIWLWVGGQAPQADALSAMGNGRAFVKKKKYPDNTLVVRVLEGHEPVEFKRLFANWLNVW 380
            |..|..|::|.|..|.:.:...||.....|::.|.||.:|.|....:|.|...||:||..|..
Frog   289 DQAGSKIFVWKGKNASKEEKQQAMTRALNFIRAKNYPASTNVEVENDGSESAVFKQLFQKWTT-- 351

  Fly   381 QENTRGHKPVST--KFGKL-----DAHSLCERPKMAADTQLVDDGRGERVIYRVFGDQVQEVPIS 438
            ::.|.|....||  |..|:     |.:|:..:|::||..::||||.||..::|:  :.::.|.:.
Frog   352 KDQTTGLGKTSTVGKVAKVEQVKFDVNSMHAKPEVAAQQKMVDDGTGETEVWRI--ENLERVLVD 414

  Fly   439 KTVVFTTNASFVVKYSVQCATVVPADLASVGIKTIIYQWNGSEASVESISRADKFAKASFDGLKE 503
            |..:    ..|   |...|..::...|.:.....|:|.|.|..||.:.|: |..:.....|  :|
Frog   415 KQYL----GHF---YGGDCYLILYKYLVNNKYHYIVYMWQGRHASQDEIT-ASAYQSVILD--QE 469

  Fly   504 PG---MFVQLYEFDEPPHFLQIFEGKLII-----RRGQRTEMPYNGNSNALLDTFLLKVYGDASY 560
            .|   :.|::....||.|.:.||:||:::     .|...:|:|        .|..|.:|:|...|
Frog   470 YGGQPVQVRVPMGKEPAHLMAIFKGKMVVYEGGTSRADSSEIP--------ADIRLFQVHGANEY 526

  Fly   561 NAKAVE-ETHLSSISSKDCYVIKTNHV-WVWCGQSSTGDAREMAKAVGALM--GENSLVLEGKES 621
            :.||.| ....||::|.|.:|:||... ::|||:..:||.|.|||.|..::  ||..::.||:|.
Frog   527 STKAFEVPVRASSLNSNDVFVLKTKGTCYLWCGKGCSGDERAMAKNVADIISKGEKVVIAEGQEP 591

  Fly   622 KEFWQSV---AMYFN------QTLVINGNGNSCSSSTSSSSGAGSMCNGSSNGGNISPTLSNNCY 677
            .:||.::   :.|.|      :||.|......||:.|                |....|
Frog   592 SDFWLALGGKSQYANNKRLQEETLDITPRLFECSNKT----------------GKFVAT------ 634

  Fly   678 LNTSVPSKPRPPVQLFLVWWQQSSLRYEEILGFDQQDLSSDCTYILDTGSLTYVWLGSQAPNQER 742
                                        ||..|:|.||..|..::||.....::|:|..:...|:
Frog   635 ----------------------------EISDFNQDDLDEDDVFLLDAWDQIFMWIGKNSNETEK 671

  Fly   743 YTA--IAQSYVQNAPFGRRSATALAVVRQFQEPNVFKGFFESWQNDYGKNFHSYEKMRKDLGNKV 805
            ..|  .||.|::..|.||...|.:.||:|..||..|.|:|.:|.....:|..||..::.:||:
Frog   672 KEAAMTAQEYLKTHPGGRDINTPIIVVKQDYEPPTFTGWFLAWDPFKWENMKSYNDLKSELGD-- 734

  Fly   806 TSNCCFASEGSALILNNRQKDFDGH--------KKYPLTVLIQEM-DMLPPDINPLKREVHLTHD 861
                  ||....:.|....:.|...        :.||..:::.:. |.||..::|.::|.:|:.|
Frog   735 ------ASTFEQISLEMTTQQFTAQTQISSPSFQTYPAEMIVNKSPDELPAGVDPSRKEEYLSTD 793

  Fly   862 DFVSVFNMSFYEFDELPKWKKMELKKQFKLF 892
            :|.::|.|:..||..||:||:..:||...||
Frog   794 EFRTIFGMTRSEFQALPEWKRQNIKKTKGLF 824

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
qua	NP_001246066.1	ADF_gelsolin	26..147	CDD:301701	30/121 (25%)
		gelsolin_like	164..254	CDD:200436	27/112 (24%)
		gelsolin_S3_like	276..375	CDD:200448	28/98 (29%)
		GEL	424..526	CDD:214590	24/104 (23%)
		ADF_gelsolin	551..625	CDD:301701	29/77 (38%)
		gelsolin_like	689..780	CDD:200436	27/92 (29%)
		VHP	857..892	CDD:128458	13/34 (38%)
vil1	NP_001096367.1	gelsolin_S1_like	17..121	CDD:200446	31/126 (25%)
		gelsolin_S2_like	136..227	CDD:200445	24/91 (26%)
		gelsolin_S3_like	253..348	CDD:200448	28/97 (29%)
		gelsolin_S4_like	392..492	CDD:200449	28/111 (25%)
		gelsolin_S5_like	515..603	CDD:200444	31/87 (36%)
		gelsolin_S6_like	619..715	CDD:200447	33/145 (23%)
		VHP	790..824	CDD:280388	13/33 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1376537at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11977
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020