DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5131 and ATP23

DIOPT Version :9

Sequence 1:	NP_609845.1	Gene:	CG5131 / 35057	FlyBaseID:	FBgn0032644	Length:	283	Species:	Drosophila melanogaster
Sequence 2:	NP_150592.1	Gene:	ATP23 / 91419	HGNCID:	29452	Length:	246	Species:	Homo sapiens

Alignment Length:	261	Identity:	96/261 - (36%)
Similarity:	147/261 - (56%)	Gaps:	33/261 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 ITGAAQEKQNAKTEKASASKETSTEETTTAQKDWGYDLYPERRGETFKPKWTRVLFGLEGQENID 85
            :.||..|::     :..|:.|...::..:.|      ::|||..:           |...|....
Human     1 MAGAPDERR-----RGPAAGEQLQQQHVSCQ------VFPERLAQ-----------GNPQQGFFS 43

  Fly    86 RF-----KCEENVYWCVKNGPLVKLMMGALKSSGCPIDLRRHISCEVCDPTVTGGYDPKLNQIVV 145
            .|     ||:..:...::..|.|||::.|:|.|||.::..||.|||.|:..|:||:|...:|||:
Human    44 SFFTSNQKCQLRLLKTLETNPYVKLLLDAMKHSGCAVNKDRHFSCEDCNGNVSGGFDASTSQIVL 108

  Fly   146 CQNMARNKSMVHGVLTHEMIHMFDYCNNDMD-FRNVDHLACTEIRAANLA-HCSFLSAMFQGDAS 208
            |||...|::.::.|:|||:||.||:|...:| |.|:.||||:|:|||||: .||.::.:|:   .
Human   109 CQNNIHNQAHMNRVVTHELIHAFDHCRAHVDWFTNIRHLACSEVRAANLSGDCSLVNEIFR---L 170

  Fly   209 PFNVKEAHQNCVKSKALASVLAVRNISKADAVAAVERVFPKCYADLEPIGRRIRRNSTDQQKAYM 273
            .|.:|:.||.||:.:|..|:||||||||..|..||:.||..|:.|.||.| ||..|.|..:.|:.
Human   171 HFGLKQHHQTCVRDRATLSILAVRNISKEVAKKAVDEVFESCFNDHEPFG-RIPHNKTYARYAHR 234

  Fly   274 E 274
            :
Human   235 D 235

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5131	NP_609845.1	Peptidase_M76	88..258	CDD:286809	78/171 (46%)
ATP23	NP_150592.1	Peptidase_M76	50..220	CDD:313061	78/172 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159511
Domainoid	1	1.000	158	1.000	Domainoid score	I4121
eggNOG	1	0.900	-	-		E1_KOG3314
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41699
Inparanoid	1	1.050	164	1.000	Inparanoid score	I4202
Isobase	1	0.950	-	0	Normalized mean entropy	S3406
OMA	1	1.010	-	-		QHG55218
OrthoDB	1	1.010	-	-		D1288109at2759
OrthoFinder	1	1.000	-	-		FOG0005453
OrthoInspector	1	1.000	-	-		oto90560
orthoMCL	1	0.900	-	-		OOG6_102968
Panther	1	1.100	-	-	LDO	PTHR21711
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R114
SonicParanoid	1	1.000	-	-		X3877
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750