Protein Alignment GCS2beta and GTB1

DIOPT Version :10

• Sequence 1: NP_609844.1
• Gene: GCS2beta / 35056
• FlyBaseID: FBgn0032643
• Length: 548
• Species: Drosophila melanogaster
• Sequence 2: NP_010507.3
• Gene: GTB1 / 851807
• SGDID: S000002629
• Length: 702
• Species: Saccharomyces cerevisiae
• Alignment Length: 727
• Identity: 168/727 - (23%)
• Similarity: 270/727 - (37%)
• Gaps: 229/727 - (31%)

  Fly     9 VLLIPLLLALVATN--VGSASEVPRPL-GVPLAKASLYQPRAGE-NSWTCLDGSR-TIPFSHIND 68
            |.:..|.|.|:..:  |.|..:..|.: |||..|..||.....: ..|.||:... .:..|.|||
Yeast     2 VSMFSLFLLLIEQSPLVASLQQSQRHIVGVPWEKQHLYDSNEPDLTKWHCLNHEDIVLDISQIND 66

  Fly    69 DYCDCADGSDEPGTAACPQG--------------QFHCVNKGHQPVNIPSSQVQDGICDCCDGSD 119
            ..|||.|||||||:|||.:.              .|:|.|||..|..|..|:|.||||||||.||
Yeast    67 GVCDCPDGSDEPGSAACVEDIFKSVAEGGGKVNKYFYCDNKGFIPRYIRKSEVADGICDCCDCSD 131

  Fly   120 E----SETVGCPNTCLELGAAAAVQRRNAAELHKRGAE----------RRQEMITRGKQMRAERE 170
            |    .|.....:.|.:|.....:........::.|.|          .::|.||||..:..::|
Yeast   132 ELLSGYELFDAGSNCSQLKNEFDIMASKELSSYREGKEALEELERKYGTKEEAITRGNCLEEDKE 196

  Fly   171 ARRLE-------LDQRRKEQELLRAEK-------------EQLKQT------------------- 196
            ....|       |.:.|.:.|.||.|.             |||..|
Yeast   197 KASAEIKVLSNRLSENRAKLEQLRGEYFNQLSHDPILYQFEQLNSTRLGSDILTSFTMVSRVSKG 261

  Fly   197 --------AEALEA-----------EAIEIFKEQQR-----EVDADT----AQA--------ERE 225
                    ::..||           :.|:.|::.:|     :::||:    .||        |..
Yeast   262 YQDIFKILSDLSEAYTPSLNDKVVNDNIKKFRKVRRRAEKAKINADSKIDDEQADNLYLYFTEEV 326

  Fly   226 PQQMRQEATLTFVRYDTNKDGFVEVTELMVDMNLDRDRNGVVTVEEAKYFLD---ERERVDL-DA 286
            ||...:..:...:||...|..||:.   :|:..::...:.:..:.|.:..:|   :...|:. ||
Yeast   327 PQIFLKRESENTLRYVIGKSNFVQA---LVEGKINYTNDILEYIREFRLIMDDISQNYNVNFQDA 388

  Fly   287 FVTLAWPRIKS----LQMLAEGLFQPPQPEE--VAQQPEVTTESIQPTPPKLSEEQAELAGDDDI 345
            .|..|....|:    ...|||  .:|..|.|  :....|||:        .::|...::...|.:
Yeast   389 GVKSAVDSYKNYLGEYGELAE--LEPAHPSESLLRSLSEVTS--------FVNENAPKVLPPDAV 443

  Fly   346 EADEEGEEDQYDDEEPDVGVGEASPDAEEATPPNYDPETQRLIQQAN--EARNALEEVERSLREI 408
            |::::...|.         :|         |..:...:.:.::.:.|  .:|..|..:|:..|..
Yeast   444 ESEQDTNSDH---------IG---------TSGDLRNKLKEILSKLNIFSSRKDLVSLEKRFRSC 490

  Fly   409 QQEV-----------------NEIDDQ--NNKGYGLTEEWAVHDGQCYNFED--REYVYTLCPFD 452
            :.:|                 :|.:|:  |:....|||...:...|.|..:|  ..||||:| |.
Yeast   491 ESQVSLLENELKQKMDYKKLLDETEDEGTNSTAGNLTELLELMGSQSYCLDDILDNYVYTIC-FQ 554

  Fly   453 RA-------SQKSRSGGPETTLGRWDKWSG-----EPKQYSQQ---------------------- 483
            |.       ..:.:..|.:..:||: |.||     ..::|::.
Yeast   555 RPMTEGVIYQAEDKVDGKKVLIGRF-KTSGFNVDLNMEKYAEHLKATYDEKSDLISNLAAIQDDD 618

  Fly   484 --------------------KYTNGAACWNGPNRSAIINISCALEPKITAVSEPNRCEYYFEFET 528
                                :|.||..|||||.|||.:.:.|:.:.||.:|.|..:|.|.|:...
Yeast   619 GNMQHYVFGNLNELNNGLVLEYENGDQCWNGPRRSATVFVRCSDKFKIRSVHEATKCNYIFDVVG 683

  Fly   529 PAACDSEAFQSE 540
            |..| ::.|:.|
Yeast   684 PLGC-NKTFEYE 694

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GCS2beta	NP_609844.1	PRKCSH-like	26..193	CDD:372423	66/217 (30%)
		SMC_prok_B	<154..428	CDD:274008	69/379 (18%)
		PRKCSH	398..547	CDD:414904	50/218 (23%)
GTB1	NP_010507.3	PRKCSH-like	28..187	CDD:372423	53/158 (34%)
		CwlO1	168..>315	CDD:443091	25/146 (17%)
		PRKCSH	<635..695	CDD:414904	23/61 (38%)