DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment GCS2beta and PRKCSH

DIOPT Version :9

Sequence 1:NP_001246063.1 Gene:GCS2beta / 35056 FlyBaseID:FBgn0032643 Length:548 Species:Drosophila melanogaster
Sequence 2:NP_001276032.1 Gene:PRKCSH / 5589 HGNCID:9411 Length:535 Species:Homo sapiens


Alignment Length:556 Identity:216/556 - (38%)
Similarity:298/556 - (53%) Gaps:38/556 - (6%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 LLIPLLLALVATNVGSASEVPRPLGVPLAKASLYQPRAGENSWTCLDGSRTIPFSHINDDYCDCA 74
            :|:||||.|   .:..|.||.||.||.|.....|..   ...:||||||.||||..:|||||||.
Human     1 MLLPLLLLL---PMCWAVEVKRPRGVSLTNHHFYDE---SKPFTCLDGSATIPFDQVNDDYCDCK 59

  Fly    75 DGSDEPGTAACPQGQFHCVNKGHQPVNIPSSQVQDGICDCCDGSDE-SETVGCPNTCLELGAAAA 138
            ||||||||||||.|.|||.|.|::|:.|||::|.||:||||||:|| :..|.|.|||.|.|....
Human    60 DGSDEPGTAACPNGSFHCTNTGYKPLYIPSNRVNDGVCDCCDGTDEYNSGVICENTCKEKGRKER 124

  Fly   139 VQRRNAAELHKRGAERRQEMITRGKQMRAEREARRLELDQRRK----EQELLRAEKEQLKQTAEA 199
            ...:..||:.:.|...::.:|...|:.|.|::.:.:||...:|    :.|:||..||:    ||.
Human   125 ESLQQMAEVTREGFRLKKILIEDWKKAREEKQKKLIELQAGKKSLEDQVEMLRTVKEE----AEK 185

  Fly   200 LEAEAIEIFKEQQREVDADTAQAEREPQQMRQEATLTFVRYDTNKDGFVEVTELMVDMNLDRDRN 264
            .|.||    |||.:::..:...|.: .||.::.|...|...|.:.||.|.||||.....||.|.:
Human   186 PEREA----KEQHQKLWEEQLAAAK-AQQEQELAADAFKELDDDMDGTVSVTELQTHPELDTDGD 245

  Fly   265 GVVTVEEAKYFLDERERVDLDAFVTLAWPRIKS---LQMLAEGLFQPPQP---EEVAQQPEVTTE 323
            |.::..||:..|....:.|..:|....|..|:.   .:.|...|..|..|   |...:||.|   
Human   246 GALSEAEAQALLSGDTQTDATSFYDRVWAAIRDKYRSEALPTDLPAPSAPDLTEPKEEQPPV--- 307

  Fly   324 SIQPTPPKLSEEQAELAGDDDIEADEEGEEDQYDDEEPDVGVGEASP-----DAEEATPPNYDPE 383
               |:.|...||:.|...:::.|.:||.|:.:...|:|.......||     .|||...|.||.:
Human   308 ---PSSPTEEEEEEEEEEEEEAEEEEEEEDSEVQGEQPKEAPPPLSPPQPASPAEEDKMPPYDEQ 369

  Fly   384 TQRLIQQANEARNALEEVERSLREIQQEVNEIDDQNNKGYGLTEEWAVHDGQCYNFEDREYVYTL 448
            ||..|..|.||||..||.||||:::::.:..::.:.:..:|...|:|....|||.....||||.|
Human   370 TQAFIDAAQEARNKFEEAERSLKDMEESIRNLEQEISFDFGPNGEFAYLYSQCYELTTNEYVYRL 434

  Fly   449 CPFDRASQKSRSGGPETTLGRWDKWSG-EPKQYSQQKYTNGAACWNGPNRSAIINISCALEPKIT 512
            |||...|||.:.||..|:||.|..|.| :..::|..||..|..||.|||||..:.:.|..|..:|
Human   435 CPFKLVSQKPKLGGSPTSLGTWGSWIGPDHDKFSAMKYEQGTGCWQGPNRSTTVRLLCGKETMVT 499

  Fly   513 AVSEPNRCEYYFEFETPAACDSEAFQSESENLHDEL 548
            :.:||:||||..|..|||||.....::.:|:.||||
Human   500 STTEPSRCEYLMELMTPAACPEPPPEAPTEDDHDEL 535

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GCS2betaNP_001246063.1 PRKCSH-like 26..193 CDD:193472 81/171 (47%)
LDLa 85..120 CDD:238060 21/34 (62%)
PRKCSH 398..547 CDD:297835 59/149 (40%)
PRKCSHNP_001276032.1 PRKCSH-like 21..163 CDD:193472 69/144 (48%)
LDLa 70..105 CDD:197566 21/34 (62%)
tolA_full <118..>279 CDD:274303 49/169 (29%)
Ax_dynein_light <137..211 CDD:287215 24/82 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 234..266 9/31 (29%)
PRKCSH 383..>514 CDD:297835 52/130 (40%)
Prevents secretion from ER. /evidence=ECO:0000255|PROSITE-ProRule:PRU10138, ECO:0000269|PubMed:10929008 532..535 2/2 (100%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 156 1.000 Domainoid score I4196
eggNOG 1 0.900 - - E1_KOG2397
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H2056
Inparanoid 1 1.050 372 1.000 Inparanoid score I2124
Isobase 1 0.950 - 0.859108 Normalized mean entropy S3335
OMA 1 1.010 - - QHG54562
OrthoDB 1 1.010 - - D250167at33208
OrthoFinder 1 1.000 - - FOG0003054
OrthoInspector 1 1.000 - - oto90249
orthoMCL 1 0.900 - - OOG6_102618
Panther 1 1.100 - - LDO PTHR12630
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R500
SonicParanoid 1 1.000 - - X3410
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
1514.860

Return to query results.
Submit another query.