Protein Alignment GCS2beta and prkcsh

DIOPT Version :10

• Sequence 1: NP_609844.1
• Gene: GCS2beta / 35056
• FlyBaseID: FBgn0032643
• Length: 548
• Species: Drosophila melanogaster
• Sequence 2: XP_005164280.1
• Gene: prkcsh / 394028
• ZFINID: ZDB-GENE-040426-770
• Length: 572
• Species: Danio rerio
• Alignment Length: 566
• Identity: 224/566 - (39%)
• Similarity: 317/566 - (56%)
• Gaps: 53/566 - (9%)

  Fly     4 LQLSQVLLIPLLLALV-ATNVGSASEVPRPLGVPLAKASLYQPRAGENS-WTCLDGSRTIPFSHI 66
            |.|..:..:.|||.|| |.::|:..||.||.||||:|...|:    ||. :||||||:||.|..:
Zfish    39 LHLGIMTCVHLLLTLVFAVSLGTPVEVHRPRGVPLSKKPFYE----ENKPFTCLDGSKTILFDQV 99

  Fly    67 NDDYCDCADGSDEPGTAACPQGQFHCVNKGHQPVNIPSSQVQDGICDCCDGSDE-SETVGCPNTC 130
            |||||||.||||||||||||.|:|||.|.|::|..||||::.||||||||.:|| :....|.|||
Zfish   100 NDDYCDCKDGSDEPGTAACPNGKFHCTNAGYKPTFIPSSRINDGICDCCDTTDEYNSGAKCENTC 164

  Fly   131 LELGAAAAVQRRNAAELHKRGAERRQEMITRGKQMRAEREARRLELDQRRKEQELLRAEKEQLKQ 195
            .|||.......:..||:.|.|...:|::|...|:.|.|::::..|:...:|:.|........:|:
Zfish   165 KELGRKEREVLQKMAEITKEGFLLKQQLIEEAKKGRGEKQSKVTEMQDNKKQLEEKVEALRTVKE 229

  Fly   196 TAEALEAEA----IEIFKEQQREVDADTAQAEREPQQMRQEATLTFVRYDTNKDGFVEVTELMVD 256
            |||..|.||    ::.::||:..:     :..::..:|.:    .|:..|.|.||.|.|:||...
Zfish   230 TAEQPEREAKERHLKAWEEQKAAI-----RLVKDKAKMAE----AFLELDDNADGLVSVSELQSH 285

  Fly   257 MNLDRDRNGVVTVEEAKYFLDERERVDLDAFVTLAWPRIKSLQMLAEGLFQPPQPEEVA------ 315
            ..||.|.:|.::..|||..:...|:||...|.:: |..||      :......||||.|
Zfish   286 AELDSDTDGTLSEAEAKGLMGGVEQVDTATFESV-WENIK------DKYHSESQPEEPAPVETPV 343

  Fly   316 ---QQPEVTTESIQPTPPKLSEEQAELAGDDDIEADEEGEEDQYDDEE----PDVGVGEASPDAE 373
               ::|.|..|| :|.|..:|||:.|   |||       ::|:|.:|:    |.:...|.|.:.|
Zfish   344 DEVKEPVVDNES-EPYPEDISEEEDE---DDD-------DDDEYHEEDEKAPPTMKTPEKSQEDE 397

  Fly   374 EATPPNYDPETQRLIQQANEARNALEEVERSLREIQQEVNEIDDQNNKGYGLTEEWAVHDGQCYN 438
            ||.|| |:.:||.||:.|.:||:..||.|::|||:..::..|:.:.:..:|...|:.....|||.
Zfish   398 EAMPP-YEADTQVLIEAAQKARDDFEEAEKALREMDDQIRNIEKELSFDFGPNAEFTYLYSQCYE 461

  Fly   439 FEDREYVYTLCPFDRASQKSRSGGPETTLGRWDKWSG-EPKQYSQQKYTNGAACWNGPNRSAIIN 502
            ....||:|.||||:|.|||.:.||.||.||.|..||| |..:|...||.:|..||.|||||..:.
Zfish   462 LSTSEYIYRLCPFNRVSQKPKFGGSETNLGTWGSWSGPENNKYLSMKYEHGTGCWQGPNRSTTVK 526

  Fly   503 ISCALEPKITAVSEPNRCEYYFEFETPAACDSEAFQSESENLHDEL 548
            ::|..|..:|:.|||:||||..||.|||.|...:....|.:.|.||
Zfish   527 LTCGKETMLTSTSEPSRCEYLMEFITPAVCQEPSNIDLSAHGHTEL 572

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GCS2beta	NP_609844.1	PRKCSH-like	26..193	CDD:372423	80/168 (48%)
		SMC_prok_B	<154..428	CDD:274008	86/290 (30%)
		PRKCSH	398..547	CDD:414904	63/149 (42%)
prkcsh	XP_005164280.1	PRKCSH-like	50..212	CDD:372423	84/165 (51%)
		COG4372	161..446	CDD:443500	95/312 (30%)
		PRK00409	<188..>262	CDD:234750	17/78 (22%)
		PRKCSH	424..556	CDD:414904	58/131 (44%)