Protein Alignment GCS2beta and Prkcsh

DIOPT Version :10

• Sequence 1: NP_609844.1
• Gene: GCS2beta / 35056
• FlyBaseID: FBgn0032643
• Length: 548
• Species: Drosophila melanogaster
• Sequence 2: NP_001280579.1
• Gene: Prkcsh / 19089
• MGIID: 107877
• Length: 528
• Species: Mus musculus
• Alignment Length: 559
• Identity: 219/559 - (39%)
• Similarity: 300/559 - (53%)
• Gaps: 55/559 - (9%)

  Fly     9 VLLIPLLLALVATNVGSASEVPRPLGVPLAKASLYQPRAGENSWTCLDGSRTIPFSHINDDYCDC 73
            :||:||..|:         ||.||.||.|:....|:.   ...:|||||:.||||..:|||||||
Mouse     6 LLLLPLCWAV---------EVKRPRGVSLSNHHFYEE---SKPFTCLDGTATIPFDQVNDDYCDC 58

  Fly    74 ADGSDEPGTAACPQGQFHCVNKGHQPVNIPSSQVQDGICDCCDGSDE--SETVGCPNTCLELGAA 136
            .||||||||||||.|.|||.|.|::|:.|.||:|.||:||||||:||  |.|| |.|||.|.|..
Mouse    59 KDGSDEPGTAACPNGSFHCTNTGYKPLYILSSRVNDGVCDCCDGTDEYNSGTV-CENTCREKGRK 122

  Fly   137 AAVQRRNAAELHKRGAERRQEMITRGKQMRAEREARRLELDQRRK----EQELLRAEKEQLKQTA 197
            .....:..||:.:.|...::.:|...|..|.|::::.|||...:|    :.|.|||.||:    |
Mouse   123 EKESLQQLAEVTREGFRLKKILIEEWKTAREEKQSKLLELQAGKKSLEDQVETLRAAKEE----A 183

  Fly   198 EALEAEAIEIFKEQQR---EVDADTAQAEREPQQMRQEATLTFVRYDTNKDGFVEVTELMVDMNL 259
            |..|.||    |:|.|   |.....|:|.||    ::.|...|...|.|.||.|.:.||.....|
Mouse   184 ERPEKEA----KDQHRKLWEEQQAAAKARRE----QERAASAFQELDDNMDGMVSLAELQTHPEL 240

  Fly   260 DRDRNGVVTVEEAKYFLDERERVDLDAFVTLAWPRIKSLQMLAEGLFQPPQPEEVAQQPEVTTES 324
            |.|.:|.::.|||:..|....:.|..:|....|..|:. :..:|   .||....|.::.|...|.
Mouse   241 DTDGDGALSEEEAQALLSGDTQTDTTSFYDRVWAAIRD-KYRSE---VPPTDIPVPEETEPKEEK 301

  Fly   325 IQPTPPKLSEEQAELAGDDDIEADEEGEEDQYDDEEPDVGVGEASPDAEEATPPN---------Y 380
            ....||...||:.|   ::..|.:||.||::...|:|.    ||.|..:...||:         |
Mouse   302 PPVLPPTEEEEEEE---EEPEEEEEEEEEEEVQGEQPK----EAPPPLQPPQPPSPTEDEKMPPY 359

  Fly   381 DPETQRLIQQANEARNALEEVERSLREIQQEVNEIDDQNNKGYGLTEEWAVHDGQCYNFEDREYV 445
            |.|||.:|..|.|||:..|||||||:|:::.:..::.:.:..:|.:.|:|....|||.....|||
Mouse   360 DEETQAIIDAAQEARSKFEEVERSLKEMEESIRSLEQEISFDFGPSGEFAYLYSQCYELTTNEYV 424

  Fly   446 YTLCPFDRASQKSRSGGPETTLGRWDKWSG-EPKQYSQQKYTNGAACWNGPNRSAIINISCALEP 509
            |.||||...|||.:.||..|:||.|..|:| :..::|..||..|..||.|||||..:.:.|..|.
Mouse   425 YRLCPFKLVSQKPKHGGSPTSLGTWGSWAGPDHDKFSAMKYEQGTGCWQGPNRSTTVRLLCGKET 489

  Fly   510 KITAVSEPNRCEYYFEFETPAACDSEAFQSESENLHDEL 548
            .:|:.:||:||||..|..|||||.....::.|:..||||
Mouse   490 VVTSTTEPSRCEYLMELMTPAACPEPPPEAPSDGDHDEL 528

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GCS2beta	NP_609844.1	PRKCSH-like	26..193	CDD:372423	83/172 (48%)
		SMC_prok_B	<154..428	CDD:274008	90/289 (31%)
		PRKCSH	398..547	CDD:414904	61/149 (41%)
Prkcsh	NP_001280579.1	PRKCSH-like	21..163	CDD:372423	71/145 (49%)
		PLN02316	<169..>214	CDD:215180	19/56 (34%)
		FRQ1	<198..257	CDD:444056	21/62 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	226..267		14/40 (35%)
		PRKCSH	380..>508	CDD:414904	52/127 (41%)
		Prevents secretion from ER. /evidence=ECO:0000255|PROSITE-ProRule:PRU10138	525..528		2/2 (100%)