DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fws and cog5

DIOPT Version :9

Sequence 1:	NP_001246059.1	Gene:	fws / 35054	FlyBaseID:	FBgn0024689	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_001038609.1	Gene:	cog5 / 567886	ZFINID:	ZDB-GENE-041210-47	Length:	810	Species:	Danio rerio

Alignment Length:	826	Identity:	217/826 - (26%)
Similarity:	383/826 - (46%)	Gaps:	133/826 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 DSDDNDFTA-SMSHLTIGQQIQELSKQLQNTKEELHQQVRDKHGALLQQATHAGRFDAALNALAE 79
            |.|...:|| ::.|..|.:|:..|::.:....:|||.||..:|..||.|||.....:..|..:..
Zfish    25 DFDVKTYTAQAIHHAVIAEQLARLAEGISQLDKELHCQVVARHEDLLAQATGIESLEGVLQMMQT 89

  Fly    80 DVQRVRETGHRLKNQVDTQYQQVENQTQVLGRLHDVSHLLRSAGTLLSLTAKLK-----ATKDVL 139
            .:..::....|::.::...|.::..:|..|.||.....|||....:|.|:.:|:     .::::.
Zfish    90 RISALQSAVDRIRTKIVDPYNKIVARTAQLARLQVACDLLRRIIRILYLSKRLQGQLQGGSREIT 154

  Fly   140 RLAEIHFELGQLIEDKELKDIDFIQQERAYVISSAQKIRNLTQMQLVTGLQERNENQVVNALKIF 204
            :.|:...||..|.:..:|..||.|:.:..::..:..::.|..:..|..|::.:|.:||..||::|
Zfish   155 KAAQSLNELDYLSQGVDLSGIDVIENDLLFISRARLEVENQAKRLLEQGMEIQNPSQVGTALQVF 219

  Fly   205 MNFNTLEKSLDNLLATFIADMEQSLKECFAGNDISVLNKSPTHNVSKPAPSRG-PGKT--PQLTT 266
            .|...|.:::.:::..:...:::::....   ||.||        ::|:.:|| ||:.  |....
Zfish   220 YNLGNLRETIRSVVDGYRTSVQENVVNAL---DIKVL--------TQPSNTRGAPGRAVMPTPGN 273

  Fly   267 TQNFRAKFWKSLHWLLYDELFETCTQIKLLKTAL----EQINQFGYTSE---SSDQCIPQRFWQQ 324
            |..|||..|.:|..|: |::...|.|::.|:..|    :.:....:..|   .....|...||..
Zfish   274 TAAFRAALWTNLEKLM-DQICAACGQVQHLQKVLTKKRDPVTHVCFIDEIIKDGQPDILHTFWSS 337

  Fly   325 VQQLLRKSFDECPQHVTQTLQEGLSKLLTSARGLEQRLHGEF----QFDNELF------------ 373
                           |||||.|.|.|...::..|:|.|.||:    :..|||:
Zfish   338 ---------------VTQTLSEELQKATAASTFLKQALEGEYPKLLRLYNELWKRLQQYSASIQG 387

  Fly   374 -----------------------------------------APLEVGYVSKCAA------NFKAC 391
                                                     .|.|..|:||..:      |....
Zfish   388 ALVSSGAGLDVELPATENDTEDLFTHAKPDYDPEKDLKDSLQPYEAAYLSKSLSRLFDPINLVFP 452

  Fly   392 LAGVDLPGNETVDNFIRVASTELSAALIDSRLTNAIANVFAACGKELCTKLEAQIKLGADSKQVV 456
            ..|.:.|.|:.:|:.|:..::||:.|.:||.||.|:|...|...:..|.|.|..:....|:.||:
Zfish   453 QGGRNPPSNDELDSIIKTIASELNVASVDSGLTIAVAKNAAKTVQLFCVKSEQLLCTQGDASQVI 517

  Fly   457 DLPNLQQQQNTQLANVLFYYKDSVRRMLSDLHVHFEKTPGTAREIISRSLEQADLLIGTILQQIM 521
            ......|::|..:.|.||..:.:|.:::|.|    ...|..|.:.::.|||....|:.:.:|.::
Zfish   518 GPLTEGQRRNIAVVNSLFRLQQAVAKVISGL----GSFPLAAEQSLTASLEAVQALMSSAVQPLL 578

  Fly   522 ESIITTISIIVLSMHREPGLNSERMSTTGP----SMYMKELQEFVNRSWSHHIA-------LFDD 575
            .|:..::..|:::||:| ..:|...:...|    |:||:|||.|:.|..:.:..       |:|.
Zfish   579 NSVTDSVEAILITMHQE-DFSSPLPAGGRPDVPCSLYMRELQGFIARVMNDYFRPLQCLDFLYDS 642

  Fly   576 KQMTKKCGHELAKRCIELFLHNVCILRPLSSCGRQRLKQDCQHMEQALKPLCPNLAELGKPSRLL 640
            .:       ::|:|.|.||:.:..:||||...|:.||..|...||.|:.|||..:::|||..|||
Zfish   643 TE-------KIAQRAITLFIRHASLLRPLGEGGKMRLAADFAQMELAVAPLCRRVSDLGKAYRLL 700

  Fly   641 RAMSLLIVQTAEELV-KQTIGEDSLVPSYIVLLLLFGHAGADLQSPH-TTANWSNERLIEWLDGH 703
            |:...|:.||.|.:. .|.:|:  |:|...:|..:|..|.|:|:||| ..|.||..|..:|||.|
Zfish   701 RSFRPLLFQTNEHIASSQALGD--LIPYSTILHFMFTRAPAELKSPHQQRAEWSISRYSQWLDDH 763

  Fly   704 TAEREKLELISGALQRYRDNARRKNIQQYDEVYPMMVDYFEQALKA 749
            ::|:::|.||.|||:.|..:.|.:..:::..|||:|:...::|..|
Zfish   764 SSEKDRLTLIRGALEAYVQSVRARQGKEFAPVYPIMLQMLQKATSA 809

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fws	NP_001246059.1	COG5	10..132	CDD:192566	31/116 (27%)
cog5	NP_001038609.1	COG5	19..142	CDD:192566	31/116 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574397
Domainoid	1	1.000	231	1.000	Domainoid score	I2368
eggNOG	1	0.900	-	-		E1_KOG2211
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	271	1.000	Inparanoid score	I2975
OMA	1	1.010	-	-		QHG55529
OrthoDB	1	1.010	-	-		D262104at33208
OrthoFinder	1	1.000	-	-		FOG0006137
OrthoInspector	1	1.000	-	-		oto38823
orthoMCL	1	0.900	-	-		OOG6_103489
Panther	1	1.100	-	-	LDO	PTHR13228
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3621
SonicParanoid	1	1.000	-	-		X5068
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800