DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fws and COG5

DIOPT Version :9

Sequence 1:	NP_001246059.1	Gene:	fws / 35054	FlyBaseID:	FBgn0024689	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_006339.4	Gene:	COG5 / 10466	HGNCID:	14857	Length:	829	Species:	Homo sapiens

Alignment Length:	803	Identity:	209/803 - (26%)
Similarity:	372/803 - (46%)	Gaps:	83/803 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 DSDDNDFTASMSH-LTIGQQIQELSKQLQNTKEELHQQVRDKHGALLQQATHAGRFDAALNALAE 79
            |.|...:|:...| ..|.:|:.:|::.:.....|||.||..:|..||.|||.....:..|..:..
Human    41 DFDVKTYTSQSIHQAVIAEQLAKLAQGISQLDRELHLQVVARHEDLLAQATGIESLEGVLQMMQT 105

  Fly    80 DVQRVRETGHRLKNQVDTQYQQVENQTQVLGRLHDVSHLLRSAGTLLSLTAKLK-----ATKDVL 139
            .:..::....|:|.::...|.::..:|..|.||.....|||....:|:|:.:|:     .::::.
Human   106 RIGALQGAVDRIKAKIVEPYNKIVARTAQLARLQVACDLLRRIIRILNLSKRLQGQLQGGSREIT 170

  Fly   140 RLAEIHFELGQLIEDKELKDIDFIQQERAYVISSAQKIRNLTQMQLVTGLQERNENQVVNALKIF 204
            :.|:...||..|.:..:|..|:.|:.:..::..:..::.|..:..|..||:.:|..||..||::|
Human   171 KAAQSLNELDYLSQGIDLSGIEVIENDLLFIARARLEVENQAKRLLEQGLETQNPTQVGTALQVF 235

  Fly   205 MNFNTLEKSLDNLLATFIADMEQSLKECFAGNDISVLNKSPTHNVSKPAPSRGPGKTPQLTTTQN 269
            .|..||:.::.:::..:.|.:|:::....   ||.||.: |:.:..:..|.|....||  ..|..
Human   236 YNLGTLKDTITSVVDGYCATLEENINSAL---DIKVLTQ-PSQSAVRGGPGRSTMPTP--GNTAA 294

  Fly   270 FRAKFWKSLHWLLYDELFETCTQIKLLKTAL----EQINQFGYTSESSDQCIPQ---RFWQQVQQ 327
            .||.||.::..|: |.::..|.|::.|:..|    :.::...:..|......|:   .||..|.|
Human   295 LRASFWTNMEKLM-DHIYAVCGQVQHLQKVLAKKRDPVSHICFIEEIVKDGQPEIFYTFWNSVTQ 358

  Fly   328 LLRKSF---DECPQHVTQTLQEGLSKLLTSARGL-------EQRLHGEF---------------- 366
            .|...|   ......:.|..:....|||.....|       .|.:.|.|
Human   359 ALSSQFHMATNSSMFLKQAFEGEYPKLLRLYNDLWKRLQQYSQHIQGNFNASGTTDLYVDLQHME 423

  Fly   367 ------------QFDNE-----LFAPLEVGYVSKCAA------NFKACLAGVDLPGNETVDNFIR 408
                        .:|.|     ...|.|..|:||..:      |......|.:.|.::.:|..|:
Human   424 DDAQDIFIPKKPDYDPEKALKDSLQPYEAAYLSKSLSRLFDPINLVFPPGGRNPPSSDELDGIIK 488

  Fly   409 VASTELSAALIDSRLTNAIANVFAACGKELCTKLEAQIKLGADSKQVVDLPNLQQQQNTQLANVL 473
            ..::||:.|.:|:.||.|::...|...:....|.|..:....|:.||:......|::|..:.|.|
Human   489 TIASELNVAAVDTNLTLAVSKNVAKTIQLYSVKSEQLLSTQGDASQVIGPLTEGQRRNVAVVNSL 553

  Fly   474 FYYKDSVRRMLSDLHVHFEKTPGTAREIISRSLEQADLLIGTILQQIMESIITTISIIVLSMHRE 538
            :....||.:::|..    ...|..|.:.|..:|:....|:...:|.::.|:...|..|:::||:|
Human   554 YKLHQSVTKVVSSQ----SSFPLAAEQTIISALKAIHALMENAVQPLLTSVGDAIEAIIITMHQE 614

  Fly   539 PGLNSERMSTTGP-----SMYMKELQEFVNRSWSHHIALFDDKQMTKKCGHELAKRCIELFLHNV 598
            ....|  :|::|.     |:||||||.|:.|..|.:...|:...........:|:|.:|||:.:.
Human   615 DFSGS--LSSSGKPDVPCSLYMKELQGFIARVMSDYFKHFECLDFVFDNTEAIAQRAVELFIRHA 677

  Fly   599 CILRPLSSCGRQRLKQDCQHMEQALKPLCPNLAELGKPSRLLRAMSLLIVQTAEELVKQ-TIGED 662
            .::|||...|:.||..|...||.|:.|.|..:::|||..|:||:...|:.|.:|.:... .:|:
Human   678 SLIRPLGEGGKMRLAADFAQMELAVGPFCRRVSDLGKSYRMLRSFRPLLFQASEHVASSPALGD- 741

  Fly   663 SLVPSYIVLLLLFGHAGADLQSPHTTANWSNERLIEWLDGHTAEREKLELISGALQRYRDNARRK 727
             ::|..|::..||..|.|:|:||...|.||:.|..:|||.|.:|:::|.||.|||:.|..:.|.:
Human   742 -VIPFSIIIQFLFTRAPAELKSPFQRAEWSHTRFSQWLDDHPSEKDRLLLIRGALEAYVQSVRSR 805

  Fly   728 NIQQYDEVYPMMVDYFEQALKAL 750
            ..:::..|||:||...::|:.||
Human   806 EGKEFAPVYPIMVQLLQKAMSAL 828

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fws	NP_001246059.1	COG5	10..132	CDD:192566	31/116 (27%)
COG5	NP_006339.4	COG5	35..158	CDD:192566	31/116 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141450
Domainoid	1	1.000	220	1.000	Domainoid score	I2632
eggNOG	1	0.900	-	-		E1_KOG2211
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	258	1.000	Inparanoid score	I3146
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55529
OrthoDB	1	1.010	-	-		D262104at33208
OrthoFinder	1	1.000	-	-		FOG0006137
OrthoInspector	1	1.000	-	-		oto91552
orthoMCL	1	0.900	-	-		OOG6_103489
Panther	1	1.100	-	-	LDO	PTHR13228
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3621
SonicParanoid	1	1.000	-	-		X5068
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800