DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cass and AT2G34040

DIOPT Version :9

Sequence 1:	NP_477454.1	Gene:	cass / 35053	FlyBaseID:	FBgn0286781	Length:	536	Species:	Drosophila melanogaster
Sequence 2:	NP_001324420.1	Gene:	AT2G34040 / 817965	AraportID:	AT2G34040	Length:	553	Species:	Arabidopsis thaliana

Alignment Length:	581	Identity:	177/581 - (30%)
Similarity:	279/581 - (48%)	Gaps:	90/581 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDNIERLYKCYEILSEAGDKISEHVDEYKEILKAVKGTSKEKRLASQFIGNFFKHFPDLADTAID 65
            :..||:||:..|.|:.:.|| |::|::|:.|:|..|.:.|.|:||||.|..:||.||.|:..|.|
plant     9 VQQIEKLYEFSERLNASKDK-SQNVEDYEGIIKMSKTSMKAKQLASQLIPRYFKFFPSLSTEAFD 72

  Fly    66 AQFDLCEDDDTQIRRQAIKDLPKLCQGNADATIRVGDTLAQLLILDDPTELQQVNNSLLAIIKLD 130
            |..|..:|.|..:|.|||:.||..|:...|...::.|.|.|||..::|.|...|:.:|:::::.|
plant    73 AHMDCIDDGDLGVRVQAIRGLPLFCKDTPDILSKIVDVLVQLLNTEEPVERDAVHKALMSLLRQD 137

  Fly   131 TKSSIAGLFQQIS---TGDETTRERCLKFIATKLLTMGPTVI--TKEIEDYIVEEIKKALQDVTA 190
            .|:|...||....   |.|:..||:.|.||..|::.:...::  .:|:|.:|.:.||::|:|||.
plant   138 PKASSTALFTHAGVTPTTDDQIREKVLNFIRDKVIPLKGELLKPQEEMERHITDLIKQSLEDVTG 202

  Fly   191 DEFHLCMTILGATKLGSTITGHA------ELVKLATEQAELNNTDADIIAVDDEVVERFIQCASA 249
            .||.:.|..|  |.| |...|.|      |||::...||:||   |.....|.:.::|.|.|...
plant   203 GEFKMFMDFL--TSL-SIFGGKAPPERMQELVEIIEGQADLN---AQFEFSDTDHIDRLISCLQL 261

  Fly   250 AAPYFSKTIKSTAFVAHVCDKLLPIKTWNMIATAVSQDQIQLRLLKVFAEMITNTDKLDNASERI 314
            |.|:|::...|:.|:.::...::|:  ::.:     .::.:|.|||..|::...| ....|.:.:
plant   262 ALPFFARGAPSSRFLIYLNKHIIPV--FDKL-----PEERKLDLLKALADISPYT-TAQEARQLL 318

  Fly   315 NAVYNVLLEYMPLPKLSDEDLGDTPPSFQFSHAECLLYALHTLGKNHPNSLSFV----------- 368
            .::..:|..|||..|..:|        ..|::.||||||.|.|....||:.:.:
plant   319 PSIVELLKIYMPARKTGEE--------MNFTYVECLLYAFHHLAHKVPNATNSLCGYKIVTGQPS 375

  Fly   369 ----EDAEKL-KDFRARLQYLARGTQGYIKKLEESL--------KGKTGEE---LKTEENQLKQT 417
                ||..:| |||..||..:...|:..:|||.:.:        ..||.||   :|| :.|...|
plant   376 DRLGEDFSELNKDFTERLTIVEDLTKATMKKLTQGMTEHNKAMSAAKTDEEKASIKT-KRQNTTT 439

  Fly   418 ALKTTSNINILIRDLFHSPPIFKHD--IVLSWIVPKNNKLGKRHAPITFGEKAAANGKD--KDQE 478
            .|:|.:||..:.:.|....|.|..|  :.|||   |...........|.|.|..||..:  .:..
plant   440 GLRTCNNILAMTKPLHAKVPPFIGDTNLNLSW---KEATKPLASTTTTIGGKRPANSNNGSGNNV 501

  Fly   479 PEKKSRPSNDQKFYSPPSGKYSNK-VNQSY----------GNNNRTRQRGGGGGGGSGGGY 528
            ..||.|          .||...|: ||:::          |.|....:||||.|.|.|.|:
plant   502 AAKKGR----------GSGTMQNQLVNKAFEGISSYGAGRGGNRGWGRRGGGRGRGQGRGH 552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cass	NP_477454.1	API5	4..505	CDD:283550	166/543 (31%)
AT2G34040	NP_001324420.1	API5	12..526	CDD:368669	167/550 (30%)
		HEAT repeat	70..98	CDD:293787	12/27 (44%)
		HEAT repeat	106..133	CDD:293787	9/26 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	203	1.000	Domainoid score	I845
eggNOG	1	0.900	-	-		E1_KOG2213
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4809
Inparanoid	1	1.050	207	1.000	Inparanoid score	I1272
OMA	1	1.010	-	-		QHG54362
OrthoDB	1	1.010	-	-		D1385954at2759
OrthoFinder	1	1.000	-	-		FOG0006081
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_105172
Panther	1	1.100	-	-	LDO	PTHR12758
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3853
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.840