Protein Alignment cass and Api5

DIOPT Version :10

• Sequence 1: NP_477454.1
• Gene: cass / 35053
• FlyBaseID: FBgn0286781
• Length: 536
• Species: Drosophila melanogaster
• Sequence 2: NP_001386658.1
• Gene: Api5 / 362170
• RGDID: 1309772
• Length: 524
• Species: Rattus norvegicus
• Alignment Length: 539
• Identity: 247/539 - (45%)
• Similarity: 336/539 - (62%)
• Gaps: 28/539 - (5%)

  Fly     1 MDNIERLYKCYEILSEAGDKISEHVDEYKEILKAVKGTSKEKRLASQFIGNFFKHFPDLADTAID 65
            |..:|.||:.|.||::|.:::.:|.|.|:.||..|||.:||||||:|||..||||||:|||:||:
  Rat     1 MPTVEELYRNYGILADATEQVGQHKDAYQVILDGVKGGTKEKRLAAQFIPKFFKHFPELADSAIN 65

  Fly    66 AQFDLCEDDDTQIRRQAIKDLPKLCQGNADATIRVGDTLAQLLILDDPTELQQVNNSLLAIIKLD 130
            ||.|||||:|..|||||||:||:...|  :...||.|.|.|||..||..|...|||:||:|.|:|
  Rat    66 AQLDLCEDEDVSIRRQAIKELPQFATG--ENLPRVADILTQLLQTDDSAEFNLVNNALLSIFKMD 128

  Fly   131 TKSSIAGLFQQISTGDETTRERCLKFIATKLLTMGPTVITKEIEDYIVEEIKKALQDVTADEFHL 195
            .|.::.|||.||..|::..|||.:||::|||.|:...|:|||:|:.|:.|.||.|:|||.:||.|
  Rat   129 AKGTLGGLFSQILQGEDIVRERAIKFLSTKLKTLPDEVLTKEVEELILTESKKVLEDVTGEEFVL 193

  Fly   196 CMTILGATKLGSTITGHAELVKLATEQAELNNTDADIIAVDDEVVERFIQCASAAAPYFSKTIKS 260
            .|.||...|...|::|..:||:|..|||:|..|   ....|.:.|:|.:||...|.|.|||.:.|
  Rat   194 FMKILSGLKSLQTVSGRQQLVELVAEQADLEQT---FSPSDPDCVDRLLQCTRQAVPLFSKNVHS 255

  Fly   261 TAFVAHVCDKLLPIKTWNMIATAVSQDQIQLRLLKVFAEMITNTDKLDNASERINAVYNVLLEYM 325
            |.||.:.|:::||  ..:.:.|.|....|||.:||:.|||.:....::.....:..:::.|||||
  Rat   256 TRFVTYFCEQVLP--NLSTLTTPVEGLDIQLEVLKLLAEMSSFCGDMEKLETNLRKLFDKLLEYM 318

  Fly   326 PLP---KLSDEDLGDTPPSFQFSHAECLLYALHTLGKNHPNSLSFVEDAEKLKDFRARLQYLARG 387
            |||   ..:.|:.|:..|..|||:.|||||:.|.||:..|:.|:...:|||||||:.||||.|||
  Rat   319 PLPPEEAENGENAGNEEPKLQFSYVECLLYSFHQLGRKLPDFLTAKLNAEKLKDFKIRLQYFARG 383

  Fly   388 TQGYIKKLEESLKGKTGEELKTEENQLKQTALKTTSNINILIRDLFHSPPIFKHDIVLSWIVPKN 452
            .|.||::|..:|:|||||.||||||::|..|||.|:|||:||:||||.||.:|..:.|||
  Rat   384 LQVYIRQLRLALQGKTGEALKTEENKIKVVALKITNNINVLIKDLFHIPPSYKSTVTLSW----- 443

  Fly   453 NKLGKRHAPITFGEKAAANGKDKDQEPEKK-SRPSND-QKFYSPPSGKYSNKVNQSYGNNNRTRQ 515
                |....:..|:|..:........|:|. ..|..| ::.|:|||||||:.:    ||.| ..|
  Rat   444 ----KPVQKVEIGQKRTSEDTSSGSPPKKSPGGPKRDARQIYNPPSGKYSSNL----GNFN-YEQ 499

  Fly   516 RGG--GGGGGSGGGYRNRR 532
            ||.  |..||.|.|.|..|
  Rat   500 RGAFRGSRGGRGWGTRGNR 518

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cass	NP_477454.1	API5	4..516	CDD:428672	236/516 (46%)
Api5	NP_001386658.1	API5	4..497	CDD:428672	236/513 (46%)
		HEAT repeat	63..91	CDD:293787	19/27 (70%)
		HEAT repeat	97..139	CDD:293787	22/41 (54%)