DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cass and Api5

DIOPT Version :9

Sequence 1:	NP_477454.1	Gene:	cass / 35053	FlyBaseID:	FBgn0286781	Length:	536	Species:	Drosophila melanogaster
Sequence 2:	NP_001292187.1	Gene:	Api5 / 11800	MGIID:	1888993	Length:	524	Species:	Mus musculus

Alignment Length:	539	Identity:	244/539 - (45%)
Similarity:	334/539 - (61%)	Gaps:	28/539 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDNIERLYKCYEILSEAGDKISEHVDEYKEILKAVKGTSKEKRLASQFIGNFFKHFPDLADTAID 65
            |..:|.||:.|.||::|.:::.:|.|.|:.||..|||.:||||||:|||..||||||:|||:||:
Mouse     1 MPTVEELYRNYGILADATEQVGQHKDAYQVILDGVKGGTKEKRLAAQFIPKFFKHFPELADSAIN 65

  Fly    66 AQFDLCEDDDTQIRRQAIKDLPKLCQGNADATIRVGDTLAQLLILDDPTELQQVNNSLLAIIKLD 130
            ||.|||||:|..|||||||:||:...|  :...||.|.|.|||..||..|...|||:||:|.|:|
Mouse    66 AQLDLCEDEDVSIRRQAIKELPQFATG--ENLPRVADILTQLLQTDDSAEFNLVNNALLSIFKMD 128

  Fly   131 TKSSIAGLFQQISTGDETTRERCLKFIATKLLTMGPTVITKEIEDYIVEEIKKALQDVTADEFHL 195
            .|.::.|||.||..|::..|||.:||::|||.|:...|:|||:|:.|:.|.||.|:|||.:||.|
Mouse   129 AKGTLGGLFSQILQGEDIVRERAIKFLSTKLKTLPDEVLTKEVEELILTESKKVLEDVTGEEFVL 193

  Fly   196 CMTILGATKLGSTITGHAELVKLATEQAELNNTDADIIAVDDEVVERFIQCASAAAPYFSKTIKS 260
            .|.||...|...|::|..:||:|..|||:|...   ....|.:.|:|.:||...|.|.|||.:.|
Mouse   194 FMKILSGLKSLQTVSGRQQLVELVAEQADLEQA---FSPSDPDCVDRLLQCTRQAVPLFSKNVHS 255

  Fly   261 TAFVAHVCDKLLPIKTWNMIATAVSQDQIQLRLLKVFAEMITNTDKLDNASERINAVYNVLLEYM 325
            |.||.:.|:::||  ..:.:.|.|....|||.:||:.|||.:....::.....:..:::.|||||
Mouse   256 TRFVTYFCEQVLP--NLSTLTTPVEGLDIQLEVLKLLAEMSSFCGDMEKLETNLRKLFDKLLEYM 318

  Fly   326 PLP---KLSDEDLGDTPPSFQFSHAECLLYALHTLGKNHPNSLSFVEDAEKLKDFRARLQYLARG 387
            |||   ..:.|:.|:..|..|||:.|||||:.|.||:..|:.|:...:|||||||:.||||.|||
Mouse   319 PLPPEEAENGENAGNEEPKLQFSYVECLLYSFHQLGRKLPDFLTAKLNAEKLKDFKIRLQYFARG 383

  Fly   388 TQGYIKKLEESLKGKTGEELKTEENQLKQTALKTTSNINILIRDLFHSPPIFKHDIVLSWIVPKN 452
            .|.||::|..:|:|||||.||||||::|..|||.|:|||:||:||||.||.:|..:.|||
Mouse   384 LQVYIRQLRLALQGKTGEALKTEENKIKVVALKITNNINVLIKDLFHIPPSYKSTVTLSW----- 443

  Fly   453 NKLGKRHAPITFGEKAAANGKDKDQEPEKK-SRPSND-QKFYSPPSGKYSNKVNQSYGNNNRTRQ 515
                |....:..|:|..:........|:|. ..|..| ::.|:|||||||:.:     :|....|
Mouse   444 ----KPVQKVEIGQKRTSEDTSSGSPPKKSPGGPKRDARQIYNPPSGKYSSNL-----SNFNYEQ 499

  Fly   516 RGG--GGGGGSGGGYRNRR 532
            ||.  |..||.|.|.|..|
Mouse   500 RGAFRGNRGGRGWGTRGNR 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cass	NP_477454.1	API5	4..505	CDD:283550	232/505 (46%)
Api5	NP_001292187.1	ARM-like and Heat-like helical repeats. /evidence=ECO:0000250	1..360		167/365 (46%)
		API5	4..495	CDD:283550	232/511 (45%)
		HEAT repeat	63..91	CDD:293787	19/27 (70%)
		HEAT_2	70..156	CDD:290374	45/87 (52%)
		HEAT repeat	97..139	CDD:293787	22/41 (54%)
		Leucine-zipper	370..391		14/20 (70%)
		Nuclear localization signal. /evidence=ECO:0000250	454..475		4/20 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845824
Domainoid	1	1.000	428	1.000	Domainoid score	I594
eggNOG	1	0.900	-	-		E1_KOG2213
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4809
Inparanoid	1	1.050	431	1.000	Inparanoid score	I1714
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54362
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006081
OrthoInspector	1	1.000	-	-		oto92279
orthoMCL	1	0.900	-	-		OOG6_105172
Panther	1	1.100	-	-	LDO	PTHR12758
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4470
SonicParanoid	1	1.000	-	-		X3853
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.790