DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sgt and TOM70

DIOPT Version :9

Sequence 1:	NP_001246058.1	Gene:	Sgt / 35052	FlyBaseID:	FBgn0032640	Length:	331	Species:	Drosophila melanogaster
Sequence 2:	NP_014278.3	Gene:	TOM70 / 855602	SGDID:	S000005065	Length:	617	Species:	Saccharomyces cerevisiae

Alignment Length:	256	Identity:	52/256 - (20%)
Similarity:	97/256 - (37%)	Gaps:	73/256 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 GAAAAAVPNNIDMFELF---------QSLYTERNPESLALAESIKNEGNRLMKENKYNEALLQYN 140
            ||..:..|:|..::.:.         ::.:|....:..|||  :|::||:..:..||::|:..||
Yeast    61 GAKKSTAPSNPPIYPVSSNGEPDFSNKANFTAEEKDKYALA--LKDKGNQFFRNKKYDDAIKYYN 123

  Fly   141 RAIAFDPKNPIFYCNRAAAHIRLGENERAVTDCKSALVYNNNYSKAYCRLGVAYSNMGNFEKAEQ 205
            .|:.. .::|:||.|.:|.::.:|:.::.|.....||....:|||...|...|...:|.|
Yeast   124 WALEL-KEDPVFYSNLSACYVSVGDLKKVVEMSTKALELKPDYSKVLLRRASANEGLGKF----- 182

  Fly   206 AYAKAIELEPDNEVYKSNLEAARNARNQPPQTGRLREDLINMLSQPMVRNLFNNAEIDVEQLLSM 270
                                                .|.:..||...:...||:|.|  |.:|..
Yeast   183 ------------------------------------ADAMFDLSVLSLNGDFNDASI--EPMLER 209

  Fly   271 LQNPMIMNTIRQQFGG-GNAPTLPNDMVQMIYNMTSQLTGFPNSNANPGNEQQPGNQPPPS 330
            ..|...|:.::::||. ..|...|.::                 :..|..|::...:..||
Yeast   210 NLNKQAMSKLKEKFGDIDTATATPTEL-----------------STQPAKERKDKQENLPS 253

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sgt	NP_001246058.1	SGTA_dimer	9..>48	CDD:293154
		TPR_11	116..177	CDD:290150	17/60 (28%)
		TPR_2	116..149	CDD:285020	10/32 (31%)
		TPR repeat	116..144	CDD:276809	10/27 (37%)
		TPR_17	139..170	CDD:290167	9/30 (30%)
		TPR repeat	149..179	CDD:276809	9/29 (31%)
		TPR_16	156..218	CDD:290168	12/61 (20%)
		TPR_1	184..217	CDD:278916	6/32 (19%)
		TPR repeat	184..212	CDD:276809	6/27 (22%)
TOM70	NP_014278.3	3a0801s09	1..614	CDD:273380	52/256 (20%)
		TPR repeat	99..127	CDD:276809	12/29 (41%)
		TPR repeat	131..161	CDD:276809	9/29 (31%)
		TPR repeat	166..189	CDD:276809	7/63 (11%)
		TPR repeat	330..358	CDD:276809
		TPR repeat	363..391	CDD:276809
		TPR repeat	396..426	CDD:276809
		TPR repeat	431..459	CDD:276809
		TPR repeat	465..493	CDD:276809
		TPR repeat	498..537	CDD:276809
		TPR repeat	542..567	CDD:276809
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345397
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840