DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sgt and TPR8

DIOPT Version :9

Sequence 1:	NP_001246058.1	Gene:	Sgt / 35052	FlyBaseID:	FBgn0032640	Length:	331	Species:	Drosophila melanogaster
Sequence 2:	NP_001031594.1	Gene:	TPR8 / 826386	AraportID:	AT4G08320	Length:	427	Species:	Arabidopsis thaliana

Alignment Length:	381	Identity:	99/381 - (25%)
Similarity:	152/381 - (39%)	Gaps:	106/381 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 QSFVRSFIDYLKKQGDVMSPDQTESIEVAIQCLQAAFDLG-------DDVEAAPAAAGEEQATTQ 64
            :..||||:::|.........|: |.:|||.:||:.||.|.       ||....|.:......:..
plant    12 RKIVRSFLNFLDSVEVAPGVDE-EGLEVARECLREAFKLNSDSSRDDDDDSFKPISLVNLFTSLD 75

  Fly    65 SSSTASAPDDDAVASGSAGIGAAAAAVPNNIDMF-----------ELFQSLY------------- 105
            ::.|...|....||:.:....::.:.|  ::|..           |||..|:
plant    76 NNETIPPPPPPPVAATTQDPSSSGSHV--SVDTCKEPSFTGTSRDELFGQLFGALEKVRYFRNTP 138

  Fly   106 -TERNPESL-------------------------ALAESIKNEGNRLMKENKYNEALLQYNRAIA 144
             .:.:|..|                         :|||::|.:||:.|:.|.|.||:..|:.|||
plant   139 DGDDDPAQLEKATRIFHDCVNEMEKSGCQTFDVNSLAETLKCQGNKAMQSNLYLEAVELYSFAIA 203

  Fly   145 FDPKNPIFYCNRAAAHIRLGENERAVTDCKSALVYNNNYSKAYCRLGVAYSNMGNFEKA-EQAYA 208
            ...||.:||||||||:.::.....|:.||..::..:.||||||.|||:||...|.:.:| |:.:.
plant   204 LTDKNAVFYCNRAAAYTQINMCSEAIKDCLKSIEIDPNYSKAYSRLGLAYYAQGKYAEAIEKGFK 268

  Fly   209 KAIELEPDNEVYKSNLEAARNARNQPPQTGRLREDLINMLSQPMVRNLFNNAEIDVEQLLSMLQN 273
            ||:.|:|.||..|.|:..|.....:..|..|..:                             ||
plant   269 KALLLDPHNESVKENIRVAEQKIREEQQRQRRSQ-----------------------------QN 304

  Fly   274 PMIMNTIRQQFGGG-------NAPTLPNDMVQMIYNMTSQLTGFPNSNANPGNEQQ 322
            .....|...:.|||       :.|..| |::.|..||.        .|..|||..:
plant   305 TSTFYTQEPEMGGGQGIPSQFSMPVNP-DLMSMFMNMA--------GNTFPGNHSR 351

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sgt	NP_001246058.1	SGTA_dimer	9..>48	CDD:293154	15/45 (33%)
		TPR_11	116..177	CDD:290150	27/60 (45%)
		TPR_2	116..149	CDD:285020	14/32 (44%)
		TPR repeat	116..144	CDD:276809	12/27 (44%)
		TPR_17	139..170	CDD:290167	14/30 (47%)
		TPR repeat	149..179	CDD:276809	12/29 (41%)
		TPR_16	156..218	CDD:290168	25/62 (40%)
		TPR_1	184..217	CDD:278916	16/33 (48%)
		TPR repeat	184..212	CDD:276809	14/28 (50%)
TPR8	NP_001031594.1	SGTA_dimer	13..73	CDD:293154	18/60 (30%)
		TPR_11	175..240	CDD:290150	27/64 (42%)
		TPR repeat	175..203	CDD:276809	12/27 (44%)
		TPR_11	208..275	CDD:290150	29/66 (44%)
		TPR repeat	208..238	CDD:276809	12/29 (41%)
		TPR	209..242	CDD:197478	11/32 (34%)
		TPR_1	243..277	CDD:278916	16/33 (48%)
		TPR repeat	243..271	CDD:276809	13/27 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0553
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	102	1.000	Inparanoid score	I2154
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D687493at2759
OrthoFinder	1	1.000	-	-		FOG0002425
OrthoInspector	1	1.000	-	-		oto4201
orthoMCL	1	0.900	-	-		OOG6_102652
Panther	1	1.100	-	-	LDO	PTHR45831
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1609
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.830