DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sgt and TTC12

DIOPT Version :9

Sequence 1:	NP_001246058.1	Gene:	Sgt / 35052	FlyBaseID:	FBgn0032640	Length:	331	Species:	Drosophila melanogaster
Sequence 2:	XP_005271661.1	Gene:	TTC12 / 54970	HGNCID:	23700	Length:	777	Species:	Homo sapiens

Alignment Length:	319	Identity:	74/319 - (23%)
Similarity:	134/319 - (42%)	Gaps:	45/319 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 QSFVRSFIDYLKKQGDVMSPDQTESIEVAIQCLQAAFDLGDDVEAAPAAAGEEQATTQSSSTASA 71
            |.|:::..:......::.|.|.....:..::..:....:.:|.|       |::..|..:.|..:
Human    10 QKFLKNVDEISNLIQEMNSDDPVVQQKAVLETEKRLLLMEEDQE-------EDECRTTLNKTMIS 67

  Fly    72 PDDDAVASGSAGIGAAAAAVPNNIDMFELFQSLYTERNPESLALAESIKNEGNRLMKENKYNEAL 136
            |...|:.|... |.:.|.......|..|     ..:|..|:..||:::|.:||....|..|..|:
Human    68 PPQTAMKSAEE-INSEAFLASVEKDAKE-----RAKRRRENKVLADALKEKGNEAFAEGNYETAI 126

  Fly   137 LQYNRAIAFDPKNPIFYCNRAAAHIRLGENERAVTDCKSALVYNNNYSKAYCRLGVAYSNMGNFE 201
            |:|:..:.......:.|.|||.|:::|.:.|:|:.||:.||..:...:|||..:|.|...:.|:.
Human   127 LRYSEGLEKLKDMKVLYTNRAQAYMKLEDYEKALVDCEWALKCDEKCTKAYFHMGKANLALKNYS 191

  Fly   202 KAEQAYAKAIELEPD---------NEV---YKSNLE--AARNARNQPPQTGRLREDLINMLSQPM 252
            .:.:.|.|.:|:.|.         |:|   .|::|:  .|....:....|....::|:..||:|.
Human   192 VSRECYKKILEINPKLQTQVKGYLNQVDLQEKADLQEKEAHELLDSGKNTAVTTKNLLETLSKPD 256

  Fly   253 VRNLFNNAEIDV---------EQLLSMLQNPMIM----NTIRQQFGGGNAPTLPNDMVQ 298
            ...||....|::         ||.|..:.|...:    ..||:.|.     |..||.|:
Human   257 QIPLFYAGGIEILTEMINECTEQTLFRMHNGFSIISDNEVIRRCFS-----TAGNDAVE 310

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sgt	NP_001246058.1	SGTA_dimer	9..>48	CDD:293154	3/38 (8%)
		TPR_11	116..177	CDD:290150	19/60 (32%)
		TPR_2	116..149	CDD:285020	9/32 (28%)
		TPR repeat	116..144	CDD:276809	9/27 (33%)
		TPR_17	139..170	CDD:290167	8/30 (27%)
		TPR repeat	149..179	CDD:276809	12/29 (41%)
		TPR_16	156..218	CDD:290168	20/70 (29%)
		TPR_1	184..217	CDD:278916	10/41 (24%)
		TPR repeat	184..212	CDD:276809	8/27 (30%)
TTC12	XP_005271661.1	TPR_11	106..171	CDD:290150	21/64 (33%)
		BamD	106..>164	CDD:276939	18/57 (32%)
		TPR repeat	106..138	CDD:276939	9/31 (29%)
		TPR repeat	106..134	CDD:276809	9/27 (33%)
		TPR repeat	139..169	CDD:276809	12/29 (41%)
		TPR_11	142..205	CDD:290150	21/62 (34%)
		TPR_1	143..173	CDD:278916	12/29 (41%)
		TPR repeat	174..202	CDD:276809	8/27 (30%)
		TPR repeat	211..236	CDD:276809	5/24 (21%)
		ARM	526..631	CDD:237987
		armadillo repeat	555..591	CDD:293788
		armadillo repeat	597..631	CDD:293788
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155691
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840