Protein Alignment Sgt and Stub1

DIOPT Version :10

• Sequence 1: NP_609842.1
• Gene: Sgt / 35052
• FlyBaseID: FBgn0032640
• Length: 331
• Species: Drosophila melanogaster
• Sequence 2: NP_001020796.2
• Gene: Stub1 / 287155
• RGDID: 1306167
• Length: 304
• Species: Rattus norvegicus
• Alignment Length: 164
• Identity: 46/164 - (28%)
• Similarity: 84/164 - (51%)
• Gaps: 9/164 - (5%)

  Fly   109 NPESLALAESIKNEGNRLMKENKYNEALLQYNRAIAFDPKNPIFYCNRAAAHIRLGENERAVTDC 173
            :|:....|:.:|.:||||....||.||...|.|||..:|...::|.|||..::::.:.|:|:.||
  Rat    20 SPDKSPSAQELKEQGNRLFVGRKYPEAAACYGRAITRNPLVAVYYTNRALCYLKMQQPEQALADC 84

  Fly   174 KSALVYNNNYSKAYCRLGVAYSNMGNFEKA----EQAY--AKAIELEPDNEVYKSNLEAARNARN 232
            :.||..:....||:..||.....|.::::|    ::||  ||...|...::: .|.|..|:..|.
  Rat    85 RRALELDGQSVKAHFFLGQCQLEMESYDEAIANLQRAYSLAKEQRLNFGDDI-PSALRIAKKKRW 148

  Fly   233 QPPQTGRLREDLINMLSQPMVRNLFNNAEIDVEQ 266
            ...:..|:.::  :.|...:.|.:....|.::|:
  Rat   149 NSIEERRIHQE--SELHSYLTRLIAAERERELEE 180

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sgt	NP_609842.1	SGTA_dimer	7..>48	CDD:465168
		TPR	116..>233	CDD:440225	40/122 (33%)
		TPR repeat	116..144	CDD:276809	13/27 (48%)
		TPR repeat	149..179	CDD:276809	10/29 (34%)
		TPR repeat	184..212	CDD:276809	10/33 (30%)
Stub1	NP_001020796.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..30		2/9 (22%)
		Spy	26..>125	CDD:443119	33/98 (34%)
		TPR 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	27..60		15/32 (47%)
		TPR repeat	27..55	CDD:276809	13/27 (48%)
		TPR repeat	60..90	CDD:276809	10/29 (34%)
		TPR 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	61..94		10/32 (31%)
		TPR repeat	95..123	CDD:276809	7/27 (26%)
		TPR 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	96..128		10/31 (32%)
		Required for interaction with MAPK7. /evidence=ECO:0000250|UniProtKB:Q9UNE7	102..201		17/82 (21%)
		CHIP_TPR_N	143..226	CDD:436460	7/40 (18%)
		Required for interaction with and ubiquitination of MYOCD. /evidence=ECO:0000269|PubMed:19237536	143..197		7/40 (18%)
		Required for ubiquitination of FOXO1. /evidence=ECO:0000250|UniProtKB:Q9UNE7	144..304		6/39 (15%)
		Required for interaction with FOXO1. /evidence=ECO:0000250|UniProtKB:Q9UNE7	144..198		6/39 (15%)
		RING-Ubox_CHIP	228..298	CDD:438316