DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sgt and TTC33

DIOPT Version :9

Sequence 1:	NP_001246058.1	Gene:	Sgt / 35052	FlyBaseID:	FBgn0032640	Length:	331	Species:	Drosophila melanogaster
Sequence 2:	NP_036514.1	Gene:	TTC33 / 23548	HGNCID:	29959	Length:	262	Species:	Homo sapiens

Alignment Length:	188	Identity:	42/188 - (22%)
Similarity:	82/188 - (43%)	Gaps:	14/188 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 GEE-QATTQSSSTASAPDDDAVASGSAGIGAAAAAVPNNIDMFELFQSLYTERNPESLALAESIK 120
            ||: ...|.....|.|.|:..|.....|         |.:...:..:.:..|...|.   ::.:|
Human    11 GEKVSKVTSQQFEAEAADEKDVVDNDEG---------NWLHAIKRRKEILLEGCAEK---SKQLK 63

  Fly   121 NEGNRLMKENKYNEALLQYNRAIAFDPKNPIFYCNRAAAHIRLGENERAVTDCKSALVYNNNYSK 185
            :||..|.:..:|.||:.:::.|:...|.:...|..::...:.|.|...||...:.|:..|.:..:
Human    64 DEGASLAENKRYREAIQKWDEALQLTPNDATLYEMKSQVLMSLHEMFPAVHAAEMAVQQNPHSWE 128

  Fly   186 AYCRLGVAYSNMGNFEKAEQAYAKAIELEPDN-EVYKSNLEAARNARNQPPQTGRLRE 242
            ::..||.|...:|....|.:::..|:.:.|.| |::|.:|..||..:.|.....|:::
Human   129 SWQTLGRAQLGLGEIILAIRSFQVALHIYPMNPEIWKEDLSWARTLQEQQKVAQRIKK 186

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sgt	NP_001246058.1	SGTA_dimer	9..>48	CDD:293154
		TPR_11	116..177	CDD:290150	14/60 (23%)
		TPR_2	116..149	CDD:285020	9/32 (28%)
		TPR repeat	116..144	CDD:276809	8/27 (30%)
		TPR_17	139..170	CDD:290167	5/30 (17%)
		TPR repeat	149..179	CDD:276809	6/29 (21%)
		TPR_16	156..218	CDD:290168	14/62 (23%)
		TPR_1	184..217	CDD:278916	7/32 (22%)
		TPR repeat	184..212	CDD:276809	6/27 (22%)
TTC33	NP_036514.1	TPR 1	59..92		9/32 (28%)
		TPR repeat	59..87	CDD:276809	8/27 (30%)
		YfgC	<71..192	CDD:331838	27/116 (23%)
		TPR repeat	92..122	CDD:276809	6/29 (21%)
		TPR 2	93..126		7/32 (22%)
		TPR 3	127..160		7/32 (22%)
		TPR repeat	127..154	CDD:276809	5/26 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0553
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810