DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sgt and Ttc12

DIOPT Version :9

Sequence 1:	NP_001246058.1	Gene:	Sgt / 35052	FlyBaseID:	FBgn0032640	Length:	331	Species:	Drosophila melanogaster
Sequence 2:	NP_766358.1	Gene:	Ttc12 / 235330	MGIID:	2444588	Length:	704	Species:	Mus musculus

Alignment Length:	194	Identity:	53/194 - (27%)
Similarity:	95/194 - (48%)	Gaps:	17/194 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 ERNPESLALAESIKNEGNRLMKENKYNEALLQYNRAIAFDPKNPIFYCNRAAAHIRLGENERAVT 171
            :|..|:..||:::|.:||.......|..|:..|:..:.......:.|.|||.|.|:||:.::|:.
Mouse    96 KRRRENRVLADALKEKGNEAFVRGDYETAIFFYSEGLGKLKDMKVLYTNRAQAFIKLGDYQKALV 160

  Fly   172 DCKSALVYNNNYSKAYCRLGVAYSNMGNFEKAEQAYAKAIELEPD---------NEV---YKSNL 224
            ||..||..:.|.:|||..:|.|:..:.|:.||::.|.|..|:.|.         |:|   .|::|
Mouse   161 DCDWALKCDENCTKAYFHMGKAHVALKNYSKAKECYQKIEEINPKLKAQVKEHLNQVTLREKADL 225

  Fly   225 E--AARNARNQPPQTGRLREDLINMLSQPMVRNLFNNAEIDVEQLLSMLQNPMIMNTIRQQFGG 286
            :  .|:.:.:....|....::|:..||:|....||....|::   |:.:.......|:.:.:||
Mouse   226 QEKEAQESLDSGKNTAVTTKNLLETLSKPGQTPLFYAGGIEI---LTEMMADCTERTLFRTYGG 286

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sgt	NP_001246058.1	SGTA_dimer	9..>48	CDD:293154
		TPR_11	116..177	CDD:290150	18/60 (30%)
		TPR_2	116..149	CDD:285020	7/32 (22%)
		TPR repeat	116..144	CDD:276809	7/27 (26%)
		TPR_17	139..170	CDD:290167	9/30 (30%)
		TPR repeat	149..179	CDD:276809	13/29 (45%)
		TPR_16	156..218	CDD:290168	24/70 (34%)
		TPR_1	184..217	CDD:278916	12/41 (29%)
		TPR repeat	184..212	CDD:276809	10/27 (37%)
Ttc12	NP_766358.1	TPR_11	105..170	CDD:290150	20/64 (31%)
		TPR 1	105..138		7/32 (22%)
		TPR repeat	105..133	CDD:276809	7/27 (26%)
		TPR repeat	138..168	CDD:276809	13/29 (45%)
		TPR 2	139..172		13/32 (41%)
		TPR_11	141..204	CDD:290150	25/62 (40%)
		TPR_1	142..172	CDD:278916	13/29 (45%)
		TPR 3	173..206		12/32 (38%)
		TPR repeat	173..198	CDD:276809	9/24 (38%)
		TPR_1	174..205	CDD:278916	11/30 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846131
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840