DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sgt and sgt-1

DIOPT Version :9

Sequence 1:	NP_001246058.1	Gene:	Sgt / 35052	FlyBaseID:	FBgn0032640	Length:	331	Species:	Drosophila melanogaster
Sequence 2:	NP_494893.1	Gene:	sgt-1 / 173846	WormBaseID:	WBGene00019893	Length:	337	Species:	Caenorhabditis elegans

Alignment Length:	357	Identity:	105/357 - (29%)
Similarity:	174/357 - (48%)	Gaps:	96/357 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 PDAV---------QQSFVRSFIDYLKKQ--GDVMSPDQTESIEVAIQCLQAAFDLGDDVEAAPAA 55
            |||.         :|:.|.||:.:::::  .:..:.:|.|::|||||||:.:|.|.|   |:.|.
Worm    10 PDAPTASPIVTRDEQNLVVSFLQFIRQKVSQNQATAEQAEALEVAIQCLEHSFGLDD---ASYAF 71

  Fly    56 AGEEQATTQSSSTASAPDDDAVASGSAGIGAAAAAVPNNIDMFELFQSLYTERNPESLALAESIK 120
            ...........|....|:           |.:|...|::.|                ::.|..:|
Worm    72 QPSRPILELFKSAEGLPE-----------GESALPTPSDSD----------------ISQANKLK 109

  Fly   121 NEGNRLMKENKYNEALLQYNRAIAFDPKNPIFYCNRAAAHIRLGENERAVTDCKSALVYNNNYSK 185
            .|||.|||.:::..|:.:||.||..: ::|:::||||||:.||.:.:.|:.||::||..:.:|||
Worm   110 EEGNDLMKASQFEAAVQKYNAAIKLN-RDPVYFCNRAAAYCRLEQYDLAIQDCRTALALDPSYSK 173

  Fly   186 AYCRLGVAYSNMGNFEKAEQAYAKAIELEPDNEVYKSN----------LEAARNARNQPPQTGRL 240
            |:.|:|:|||....:|.|.:||.||:||||:.|.||:|          ||::|.|....|..|.|
Worm   174 AWGRMGLAYSCQNRYEHAAEAYKKALELEPNQESYKNNLKIAEDKLKELESSRPAPGANPLAGLL 238

  Fly   241 ------------------REDLIN----------MLSQPMVRNLFNN--------AEIDV--EQL 267
                              .::|:|          |:|.|.:.::|||        |::..  :|:
Worm   239 GAMGGGPGGMPAMPGMPNMQNLMNEPGLMQAASQMMSDPALSDMFNNMMSGNGSIADLMAAGQQM 303

  Fly   268 LSMLQ--NPMIMNTIRQQFG----GGNAPTLP 293
            .:.:|  ||.::..:|:|||    ||..|..|
Worm   304 AARMQETNPELIENLRRQFGPGADGGAPPPNP 335

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sgt	NP_001246058.1	SGTA_dimer	9..>48	CDD:293154	14/40 (35%)
		TPR_11	116..177	CDD:290150	25/60 (42%)
		TPR_2	116..149	CDD:285020	13/32 (41%)
		TPR repeat	116..144	CDD:276809	12/27 (44%)
		TPR_17	139..170	CDD:290167	13/30 (43%)
		TPR repeat	149..179	CDD:276809	14/29 (48%)
		TPR_16	156..218	CDD:290168	30/61 (49%)
		TPR_1	184..217	CDD:278916	18/32 (56%)
		TPR repeat	184..212	CDD:276809	14/27 (52%)
sgt-1	NP_494893.1	SGTA_dimer	25..83	CDD:293154	17/60 (28%)
		TPR_11	104..169	CDD:290150	27/65 (42%)
		TPR repeat	105..133	CDD:276809	12/27 (44%)
		TPR_11	137..203	CDD:290150	31/65 (48%)
		TPR repeat	137..167	CDD:276809	14/29 (48%)
		TPR	138..171	CDD:197478	14/32 (44%)
		TPR_1	172..204	CDD:278916	17/31 (55%)
		TPR repeat	172..200	CDD:276809	14/27 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0553
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	133	1.000	Inparanoid score	I3173
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55994
OrthoDB	1	1.010	-	-		D501335at33208
OrthoFinder	1	1.000	-	-		FOG0002425
OrthoInspector	1	1.000	-	-		oto20125
orthoMCL	1	0.900	-	-		OOG6_102652
Panther	1	1.100	-	-	LDO	PTHR45831
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1333
SonicParanoid	1	1.000	-	-		X1609
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.870