DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment BicD and Bicd2

DIOPT Version :9

Sequence 1:	NP_001260531.1	Gene:	BicD / 35051	FlyBaseID:	FBgn0000183	Length:	802	Species:	Drosophila melanogaster
Sequence 2:	NP_001034268.1	Gene:	Bicd2 / 76895	MGIID:	1924145	Length:	851	Species:	Mus musculus

Alignment Length:	838	Identity:	332/838 - (39%)
Similarity:	479/838 - (57%)	Gaps:	114/838 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 LQMEVERLTRELDQVSSASAQSAQYGLSLLEEKSALQQKCEELETLYDNTRHELDITQEALTKFQ 82
            |:.||:||:.||.:.:....|:|:|||::||||..|:.:.||||..|:..|.|::..:||..:..
Mouse    22 LRAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSEMEQLKEAFGQAH 86

  Fly    83 TSQKVTNKTGIEQEDALLNESAARETSLNLQIFDLENELKQLRHELERVRNERDRMLQENSDFGR 147
            |:.|.....|..:|::|:.|||::|.....::.:|:.||||||:.|...::|.:|:.....:...
Mouse    87 TNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQLRNVLTNTQSENERLTSVAQELKE 151

  Fly   148 DKSDSEADRLRLKSELKDLKFRETRMLSEYSELEEENISLQKQVSSLRSSQVEFEGAKHEIRRLT 212
            ...:.|..|.||:.::|:.||||.|:|.:||||||||||||||||.||.:||||||.||||:||.
Mouse   152 INQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENISLQKQVSVLRQNQVEFEGLKHEIKRLE 216

  Fly   213 EEVELLNQQVDELANLKKIAEKQMEEALETLQGEREAKYALKKELDGHLNRESMYHISNLAYSIR 277
            ||.|.||.|:::...||:|:|:|:|||||||:.|||.|..|:|||..:::....::.|:|..|:.
Mouse   217 EETEYLNSQLEDAIRLKEISERQLEEALETLKTEREQKNNLRKELSHYMSINDSFYTSHLQVSLD 281

  Fly   278 ----SNMEDNASNNSDGEE-----ENLALKRLEADLSTELKSPDGTK-------CDLFSEIHLNE 326
                |:....|..|:|.|.     |:..|.:...|..|.....||..       .||.||:|::|
Mouse   282 GLKFSDDTVTAEPNNDAEALVNGFEHSGLVKSSLDNKTSTPRKDGLAPPSPSLVSDLLSELHISE 346

  Fly   327 LKKLEKQLESMESEKTHLTANLREAQTSLDKSQNELQNFMSRLALLAAHVDALVQL--------- 382
            ::||::||..||.||..|.|.|::.|..|::::..|.....::..|..::.||.:|
Mouse   347 IQKLKQQLVQMEREKVGLLATLQDTQKQLEQARGTLSEQHEKVNRLTENLSALRRLQAGKERQTS 411

  Fly   383 ---KKQIDVKEQG---------------------KEGGQKKDELEQQLRALISQYANWFTLSAKE 423
               :|..|..|.|                     .|.|    ||.:||:||.|      |..|:|
Mouse   412 LDNEKDRDSHEDGDYYEVDINGPEILACKYHVAVAEAG----ELREQLKALRS------THEARE 466

  Fly   424 IDGLKTDIAELQKGLNYTDATTTLRNEVTNLKNKLLATEQKSLDLQSDVQTLTHISQNAGQSLGS 488
            ....:.......:|...|:..:.| .:.::...:|||..:|.|...|||         ||::.||
Mouse   467 AQHAEEKGRYEAEGQALTEKISLL-EKASHQDRELLAHLEKELKKVSDV---------AGETQGS 521

  Fly   489 ---ARSTLVALSDDLAQLYHLVCTVNGETPTRVLLDHKTDDMSFENDSLTAIQSQFKSDVFIAKP 550
               |:..||..|::||.|||.||..|.|||.||:||:..:.......:....:.: :|.|.:.|.
Mouse   522 LNVAQDELVTFSEELANLYHHVCMCNNETPNRVMLDYYREGQGKAGRTSPEGRGR-RSPVLLPKG 585

  Fly   551 QIVEDLQGLADS------------------------VEIKKYVDTVSDQIKYLKTAVEHTIDMNK 591
            .:..:: |.||.                        :.|...:..:.||||:|:.||:.|.::::
Mouse   586 LLATEV-GRADGGTGDNSPSPSSSLPSPLSDPRREPMNIYNLIAIIRDQIKHLQAAVDRTTELSR 649

  Fly   592 HKIRS-EGGDALEKVNTEEMEELQEQIVKLKSLLSVKREQIGTLRNVLKSNKQTAEVALTNLKSK 655
            .:|.| |.|.|::|    :.|.|.|:|:|||||||.|||||.|||.|||:|||||||||.|||||
Mouse   650 QRIASQELGPAVDK----DKEALMEEILKLKSLLSTKREQITTLRTVLKANKQTAEVALANLKSK 710

  Fly   656 YENEKIIVSDTMSKLRNELRLLKEDAATFSSLRAMFAARCEEYVTQVDDLNRQLEAAEEEKKTLN 720
            |||||.:|::||.||||||:.||||||||||||||||.||:||:||:|::.|||.|||:||||||
Mouse   711 YENEKAMVTETMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLN 775

  Fly   721 QLLRLAVQQKLALTQRLEEMEMDREMRHVRRPMPAQRGTSGKSSFSTRPSSRNPASSN 778
            .|||:|:|||||||||||.:|:|.|.        .:||.| |::...:|:|  |:.|:
Mouse   776 SLLRMAIQQKLALTQRLELLELDHEQ--------TRRGRS-KAASKAKPAS--PSVSH 822

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BicD	NP_001260531.1	BicD	80..742	CDD:286773	295/738 (40%)
Bicd2	NP_001034268.1	Interaction with DYNLL1, DYNC1H1, DYNC1I2, DCTN1 and DCTN2. /evidence=ECO:0000269\|PubMed:22956769	25..400		147/374 (39%)
		DUF342	<55..169	CDD:302792	33/113 (29%)
		BicD	83..797	CDD:286773	295/739 (40%)
		MreC	<178..>230	CDD:302802	37/51 (73%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	313..332		4/18 (22%)
		Interaction with KIF5A. /evidence=ECO:0000269\|PubMed:20386726	336..595		78/280 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	400..427		5/26 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	563..582		2/19 (11%)
		Interaction with RANBP2. /evidence=ECO:0000269\|PubMed:20386726	586..820		128/249 (51%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	591..618		3/27 (11%)
		Interaction with RAB6A. /evidence=ECO:0000269\|PubMed:12447383, ECO:0000269\|PubMed:20386726, ECO:0000269\|PubMed:25962623	662..810		108/160 (68%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	799..820		8/31 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847336
Domainoid	1	1.000	449	1.000	Domainoid score	I518
eggNOG	1	0.900	-	-		E1_KOG0999
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9070
Inparanoid	1	1.050	504	1.000	Inparanoid score	I1336
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48464
OrthoDB	1	1.010	-	-		D250005at33208
OrthoFinder	1	1.000	-	-		FOG0001590
OrthoInspector	1	1.000	-	-		otm44170
orthoMCL	1	0.900	-	-		OOG6_104968
Panther	1	1.100	-	-	O	PTHR31233
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4141
SonicParanoid	1	1.000	-	-		X1419
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.800