DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment BicD and zgc:162200

DIOPT Version :9

Sequence 1:	NP_001260531.1	Gene:	BicD / 35051	FlyBaseID:	FBgn0000183	Length:	802	Species:	Drosophila melanogaster
Sequence 2:	NP_001077017.1	Gene:	zgc:162200 / 558638	ZFINID:	ZDB-GENE-030131-2989	Length:	852	Species:	Danio rerio

Alignment Length:	858	Identity:	294/858 - (34%)
Similarity:	459/858 - (53%)	Gaps:	109/858 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 QDLQMEVERLTRELDQVSSASAQSAQYGLSLLEEKSALQQKCEELETLYDNTRHELDITQEALTK 80
            :.||||||||..||.:.:....|:|:|||::|||.:.|:.|..:||..::..:.|:...:|||..
Zfish    18 EGLQMEVERLMAELQEANEEKLQAARYGLAVLEESAVLKSKHSQLEEEHEALKMEVQQLREALAD 82

  Fly    81 FQTSQKVTNKTGIEQEDALLNESAARETSLNLQIFDLENELKQLRHELERVRNERDRMLQENSDF 145
            ..:|.|.....|..:|:.||.|||.:|..:::::.:|:.||||.|..|.....|.:|::..::..
Zfish    83 SVSSHKRAAADGESREERLLQESANKEAEMDIRMDELQAELKQARVMLNNTSAENERLVSLSTQM 147

  Fly   146 GRDKSDSEADRLRLKSELKDLKFRETRMLSEYSELEEENISLQKQVSSLRSSQVEFEGAKHEIRR 210
            .::....|.::.|::.|:|:.|.||.:.|.:.|||||||||||||||.|:.:|||||..|.|:..
Zfish   148 KKECECLEVEKTRMREEMKEYKTREAQQLQDNSELEEENISLQKQVSVLKENQVEFESVKLELTH 212

  Fly   211 LTEEVELLNQQVDELANLKKIAEKQMEEALETLQGEREAKYALKKELDGHLNRESMYHISNLAYS 275
            ..||:||:..|::|...|::|||.|::||||.|:.|||.|.:|::|: ..|.......||:|...
Zfish   213 KDEELELMRAQLEEAGRLREIAEHQLDEALEALKEEREQKNSLRREV-AALTLNPFDSISHLEIQ 276

  Fly   276 IRSNME--------------DNASNNSDGEEENLALKRLEADLSTELKSPDGTKCDLFSEIHLNE 326
            :..:.:              |:..|||.|.|.|.......:::....::| |...||.||:||::
Zfish   277 LNDSRDGEKDREEGEEDEEMDSGYNNSKGMERNRCSTPRNSEVFLRPQAP-GLVSDLLSELHLSD 340

  Fly   327 LKKLEKQLESMESEKTHLTANLREAQTSLDKSQNELQNFMSRLALLAAHVDALVQLKKQIDVKE- 390
            .:||::||..:|.||..|::.:.|.|..|.:|::.......::..|..|::.|..:..:...::
Zfish   341 SQKLKQQLIQVEREKATLSSTVHELQQQLVQSKDAFSEQQEKMDQLTQHLENLQNMITKRSAEDG 405

  Fly   391 ---------QGKEGGQKKDELEQQLRALIS---QYANWFTLSAKEIDGLKTDIAELQKGLNYTDA 443
                     |..|.|....|::.:...::.   |.||      :|:..|...:.:.:|.....:.
Zfish   406 NRMSSSPTSQDPENGINYYEVDTKSTEVLECRMQAAN------EELARLHVKLKDAEKRYKTLEE 464

  Fly   444 TTTL-----RNEVTNLKNKL-------LATEQKSLDLQSDVQTLTHISQNAGQSLGSARSTLVAL 496
            ...|     |.|..:|.:::       ...:::...|:.::.....::.::...|.:|:..|:|.
Zfish   465 RCKLEKQRWRGEAQDLADQIRQCITASRQDQERIGQLEREIGATRKVATDSEGHLSAAQEELLAF 529

  Fly   497 SDDLAQLYHLVCTVNGETPTRVLLDH--------KTDDMSFENDSLTAIQSQFKSDVFI------ 547
            |:|||.|||.||..|..||:||.||:        :|.:....:....:::.|.:|...:
Zfish   530 SEDLANLYHHVCVSNNLTPSRVTLDYYREGAQAVRTQNHQLPHHYRGSLRRQRRSGEVLDPNSTG 594

  Fly   548 ------------AKPQIVEDLQGLADSVEIKKYVDTVSDQIKYLKTAVEHTIDMNKHKIRSEGGD 600
                        ..|.:     ...|...::..|..:..|||:|:.||:.....:.....:.||
Zfish   595 SGDAPSNCGSCPGSPTL-----DFRDPTNVRNLVAVIRCQIKHLQVAVDLCRQRSLLSSPAAGG- 653

  Fly   601 ALEKVNTE---EMEELQEQIVKLKSLLSVKREQIGTLRNVLKSNKQTAEVALTNLKSKYENEKII 662
                 :||   :.|.|.|:::|||||||.|||||.|||.|||:||||||:||||||:|||.||.:
Zfish   654 -----STESDRDTEALIEEVLKLKSLLSTKREQIATLRTVLKANKQTAELALTNLKTKYETEKSM 713

  Fly   663 VSDTMSKLRNELRLLKEDAATFSSLRAMFAARCEEYVTQVDDLNRQLEAAEEEKKTLNQLLRLAV 727
            |::||.||||||:.||||||||||||.|||:||::||||:|::.|||.|||:||||||.|||:|:
Zfish   714 VTETMMKLRNELKALKEDAATFSSLRVMFASRCDQYVTQLDEMQRQLAAAEDEKKTLNSLLRMAI 778

  Fly   728 QQKLALTQRLEEMEMDREMRHVRRPM-PAQRGTSGKSSFSTR-----------PSSRNPASSNAN 780
            |||||||||||::|         .|: |...|.|.:.|..|:           |...:|.||...
Zfish   779 QQKLALTQRLEDLE---------APLFPLSNGGSPRHSSRTKHMNKTGRAPRSPMRSSPRSSPVL 834

  Fly   781 P-FXHKISVQRKL 792
            | . |..::.|.|
Zfish   835 PTASHMRAISRSL 847

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BicD	NP_001260531.1	BicD	80..742	CDD:286773	253/729 (35%)
zgc:162200	NP_001077017.1	TMPIT	49..>136	CDD:285135	28/86 (33%)
zgc:162200	NP_001077017.1	BicD	81..793	CDD:286773	254/739 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592567
Domainoid	1	1.000	416	1.000	Domainoid score	I631
eggNOG	1	0.900	-	-		E1_KOG0999
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	473	1.000	Inparanoid score	I1462
OMA	1	1.010	-	-		QHG48464
OrthoDB	1	1.010	-	-		D250005at33208
OrthoFinder	1	1.000	-	-		FOG0001590
OrthoInspector	1	1.000	-	-		otm24786
orthoMCL	1	0.900	-	-		OOG6_104968
Panther	1	1.100	-	-	O	PTHR31233
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1419
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.770