Protein Alignment BicD and bicd2

DIOPT Version :9

• Sequence 1: NP_001260531.1
• Gene: BicD / 35051
• FlyBaseID: FBgn0000183
• Length: 802
• Species: Drosophila melanogaster
• Sequence 2: XP_005155947.1
• Gene: bicd2 / 557383
• ZFINID: ZDB-GENE-120717-1
• Length: 846
• Species: Danio rerio
• Alignment Length: 865
• Identity: 321/865 - (37%)
• Similarity: 484/865 - (55%)
• Gaps: 127/865 - (14%)

  Fly     1 MSSASNNGPSADQSVQD-----LQMEVERLTRELDQVSSASAQSAQYGLSLLEEKSALQQKCEEL 60
            ||...:..|.| |.|.:     |:.|:|||:|||.:.|....|:|:|||.:|||...|:|:.|||
Zfish     1 MSGDEDGCPGA-QLVTEAGPNWLRAEIERLSRELSETSREKIQAAEYGLVVLEENQQLKQRFEEL 64

  Fly    61 ETLYDNTRHELDITQEALTKFQTSQKVTNKTGIEQEDALLNESAARETSLNLQIFDLENELKQLR 125
            |:.|:..|.|||..:||..:..::.:.....|..:|::|:.|||::|.....::.:|:::|:|.:
Zfish    65 ESEYETVRQELDQLREAYGQVHSTHRKVAADGESREESLILESASKEAYYEQRVQELQSDLRQAK 129

  Fly   126 HELERVRNERDRM------LQENSDFGRDKSDSEADRLRLKSELKDLKFRETRMLSEYSELEEEN 184
            :.|...:.|.:|:      |:||::.      .|..|.||:.::::.|.||:|:|.:|:||||||
Zfish   130 NTLTGTQAENERLATLALELRENNEI------VELQRSRLRDDIREYKIRESRLLQDYTELEEEN 188

  Fly   185 ISLQKQVSSLRSSQVEFEGAKHEIRRLTEEVELLNQQVDELANLKKIAEKQMEEALETLQGEREA 249
            ||||||||:|:..||||||.|||.|||.|||:.||.|:::...|::||::|:.|||||::.|||.
Zfish   189 ISLQKQVSTLKQGQVEFEGLKHENRRLEEEVQYLNSQLEDAIRLREIADRQLTEALETVKTEREQ 253

  Fly   250 KYALKKELDGHLNRESMYHISNLAYSIRSNMEDNASNNSDGEEENLALKRLE---------ADLS 305
            |.||:|||..|:         .|..|:.::..|....::|....:.|:..||         .|..
Zfish   254 KAALRKELTHHM---------TLGDSLLASSLDGLKLSADEPNNDDAILTLENGFAKVCEGNDED 309

  Fly   306 TELKSPDGTK---------CDLFSEIHLNELKKLEKQLESMESEKTHLTANLREAQTSLDKSQNE 361
            ..|.||...:         .||.:|::::|::||::||..:|.||..|...|:::|..|:.::..
Zfish   310 NRLSSPKRDENFRPAPSLVDDLLTELNISEIQKLKQQLLQVEREKVALLTTLQDSQKQLEHARGA 374

  Fly   362 LQNFMSRLALLAAHVDALVQL---KKQIDVKEQGKEGGQKKD----------------------- 400
            |......:..|:..:.|:.:|   |::....:..:|...::|
Zfish   375 LAEQQEAMTRLSDDLGAMRRLQAGKERQSALDSERERDSREDNDVDYYELDINGPEILRCKYEVA 439

  Fly   401 -----ELEQQLRALISQYANWFTLSAKEIDGLKTDIAELQKGLNYTDATTTLRNEVTNLKNKLLA 460
                 ||.::|:.|.|::           |.:||:..|::         |.|...|.:|..::..
Zfish   440 IAEAGELREELKGLKSEH-----------DEMKTEHEEVR---------TRLEGHVRDLSIQVSQ 484

  Fly   461 TEQKSLDLQSDV----QTLTHISQNAGQSLGS---ARSTLVALSDDLAQLYHLVCTVNGETPTRV 518
            .|..|...:..|    :.|..:|..||::.||   |:..|||.|::||.|||.||..|.|||.||
Zfish   485 LEYSSRTDRDKVAKLEKELKEVSAVAGETEGSLSVAQDELVAFSEELANLYHHVCMCNNETPNRV 549

  Fly   519 LLD-------HKTDDMSFENDSLTAIQSQFKSDVFIAKPQIVEDLQGLADSVEIKKYVDTVSDQI 576
            :||       .||:  :.:..|.....::.|:....:....|:..:...:.:::...|..:.|||
Zfish   550 MLDFYKEGKGSKTE--TKDRQSTLTQTNESKAQTSRSNSIPVDREEPRPEPMDVYNLVAIIRDQI 612

  Fly   577 KYLKTAVEHTIDMNKHKIRSEGGDALEKVNTEEMEELQEQIVKLKSLLSVKREQIGTLRNVLKSN 641
            ::|:.||:.|.::::.::.|.   .|..|..::.....|:|:|||||||.|||||.|||.|||:|
Zfish   613 RHLQKAVDRTTELSRQRVASL---ELAAVADKDQAACMEEILKLKSLLSTKREQIATLRTVLKAN 674

  Fly   642 KQTAEVALTNLKSKYENEKIIVSDTMSKLRNELRLLKEDAATFSSLRAMFAARCEEYVTQVDDLN 706
            ||||||||.||||||||||.:|::||.||||||:.||||||||||||||||.||:|||||:||:.
Zfish   675 KQTAEVALANLKSKYENEKAMVTETMMKLRNELKALKEDAATFSSLRAMFATRCDEYVTQLDDMQ 739

  Fly   707 RQLEAAEEEKKTLNQLLRLAVQQKLALTQRLEEMEMDREMRHVRRPMPAQRGTSGKS-------- 763
            |||.|||:||||||.|||:|:|||||||||||::|.|.|..  ||...|..|..||:
Zfish   740 RQLAAAEDEKKTLNSLLRMAIQQKLALTQRLEDLEFDNEQS--RRGSGAGPGGRGKAPSGRGRGP 802

  Fly   764 -SFST-RPSSRNPASSNANP 781
             |||: ..|.|.|..:...|
Zfish   803 LSFSSPHVSPRLPCKNRPQP 822

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
BicD	NP_001260531.1	BicD	80..742	CDD:286773	269/730 (37%)
bicd2	XP_005155947.1	BicD	83..775	CDD:286773	269/731 (37%)
		Tmemb_cc2	<134..>249	CDD:287269	57/120 (48%)
		MreC	<178..>230	CDD:302802	35/51 (69%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592565
Domainoid	1	1.000	416	1.000	Domainoid score	I631
eggNOG	1	0.900	-	-		E1_KOG0999
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9070
Inparanoid	1	1.050	473	1.000	Inparanoid score	I1462
OMA	1	1.010	-	-		QHG48464
OrthoDB	1	1.010	-	-		D250005at33208
OrthoFinder	1	1.000	-	-		FOG0001590
OrthoInspector	1	1.000	-	-		otm24786
orthoMCL	1	0.900	-	-		OOG6_104968
Panther	1	1.100	-	-	O	PTHR31233
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1419
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.770