DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment BicD and bicd1a

DIOPT Version :9

Sequence 1:	NP_001260531.1	Gene:	BicD / 35051	FlyBaseID:	FBgn0000183	Length:	802	Species:	Drosophila melanogaster
Sequence 2:	XP_684729.2	Gene:	bicd1a / 556758	ZFINID:	ZDB-GENE-081031-9	Length:	976	Species:	Danio rerio

Alignment Length:	897	Identity:	316/897 - (35%)
Similarity:	469/897 - (52%)	Gaps:	152/897 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 GPSADQSVQDLQMEVERLTRELDQVSSASAQSAQYGLSLLEEKSALQQKCEELETLYDNTRHELD 72
            |....:||...:.|||||||||.:.:....::|:.||.:|||...|:.:..|||...:..:.||:
Zfish     4 GGGCGESVDQYRSEVERLTRELAEANREKIRAAECGLVVLEENQKLKHQYAELEIEQEALKQELE 68

  Fly    73 ITQEALTKFQTSQKVTNKTGIEQEDALLNESAARETSLNLQIFDLENELKQLRHELERVRNERDR 137
            ..|||..:..|:|:...:.|...|:.||.|||::|.....::.||:::||.........:.|.:.
Zfish    69 QLQEAFGQAYTNQRKVAEDGETNEETLLQESASKEAYYMGRLDDLQSQLKVSSSAASNAQAETEH 133

  Fly   138 M------LQENSDFGRDKSDSEADRLRLKSELKDLKFRETRMLSEYSELEEENISLQKQVSSLRS 196
            :      |:||::      ..|..|.|::.|:::.||||.|:|.:|:|||||||:|||.||:|:.
Zfish   134 LNALMQELRENNE------TLELQRSRMREEIREYKFREARLLQDYTELEEENITLQKLVSTLKQ 192

  Fly   197 SQVEFEGAKHEIRRLTEEVELLNQQVDELANLKKIAEKQMEEALETLQGEREAKYALKKELDGHL 261
            :|||:||.||||:.|.||..|||.|:::...||.|::.|:||||::|:.|||.|..|:|||..||
Zfish   193 NQVEYEGLKHEIKVLEEETVLLNSQLEDALRLKDISQGQLEEALDSLKSEREQKNNLRKELAHHL 257

  Fly   262 N-RESMYHIS-NLAYSIRSNM---EDNASNNSDGEEENLALKRLEADLSTELKSPDGTKC----- 316
            : .:|:|..| :||.|....:   |:.|:|.:...             .|...:.|..:|
Zfish   258 SLTDSVYGASTHLAISAVEGLKFAEEAATNGTSAS-------------GTSPNNEDSNRCNNECN 309

  Fly   317 -------------------DLFSEIHLNELKKLEKQLESMESEKTHLTANLREAQTSLDKSQNEL 362
                               |||||::|:|::||::||..:|.||..|..||:|:||.|..:|..|
Zfish   310 GHGPKGEYHRRKTEMLPVSDLFSELNLSEIQKLKQQLIQVEREKAILLTNLQESQTQLQHTQGAL 374

  Fly   363 QNFMSRLALLAAHVDALVQL--KKQIDVKEQGKEGGQKKD--ELEQQLRALISQYANWFTLSAKE 423
            .....|:..|...|:|:.:|  .|:.|.:|..|..|....  |.|..:.. |......:.::..|
Zfish   375 TEQHRRVHRLTERVNAMKRLHNDKEFDTEESEKGDGPINGCCEFETDING-IELLECKYRVAVTE 438

  Fly   424 IDGLKTDIAELQKGLNYTDATTTLRNEVTNLKNKLLATEQ--KSLD------------LQSDVQT 474
            :..||.::..|::  .|..:..:...|..:.:.|:.|.|:  |.|:            |:::::.
Zfish   439 VIDLKAELKVLKE--KYNQSLESQSEESNHSEGKVQALEEQVKQLEKSCREARERVSSLEAELRC 501

  Fly   475 LTHISQNAGQSLGSARSTLVALSDDLAQLYHLVCTVNGETPTRVLLDHKTDDMSFENDS------ 533
            .:.::..:...|.:|:..||..|::||||||.||..|.|||.||:||:........:.|
Zfish   502 ASGMASESNGMLNAAQDELVTFSEELAQLYHHVCLCNNETPNRVMLDYYRQSRVTRSGSLKGPED 566

  Fly   534 ------------LTAIQSQFKSDVFIAKPQIVEDLQGLADSVE---------------------- 564
                        |.|:.|...|    ..||.....:.|.|.::
Zfish   567 PRALLSPRLARRLAAVNSSDMS----KSPQDSPSKEPLGDGIKGEGGSPNRTPFGSPINGSSLSS 627

  Fly   565 ---------------IKKYVDTVSDQIKYLKTAVEHTIDMNKHKIRSEGGDALEKVNTEEMEELQ 614
                           |......:.||||:|:.||:.::.:::.:..:.   .|..:..::.|...
Zfish   628 STIPETGDLRREPMNIYNLNAIIRDQIKHLQKAVDRSLQLSRQRAAAR---ELAPILDKDKEACM 689

  Fly   615 EQIVKLKSLLSVKREQIGTLRNVLKSNKQTAEVALTNLKSKYENEKIIVSDTMSKLRNELRLLKE 679
            |:|:|||||||.|||||.|||.|||:|||||||||.||||||||||.:|::||.||||||:.|||
Zfish   690 EEILKLKSLLSTKREQIATLRLVLKANKQTAEVALANLKSKYENEKCMVTETMMKLRNELKALKE 754

  Fly   680 DAATFSSLRAMFAARCEEYVTQVDDLNRQLEAAEEEKKTLNQLLRLAVQQKLALTQRLEEMEMDR 744
            |||||||||||||.||:|||||:|::.|||.|||:||||||.|||:|:|||||||||||::|.|.
Zfish   755 DAATFSSLRAMFATRCDEYVTQLDEMQRQLAAAEDEKKTLNSLLRMAIQQKLALTQRLEDLEFDH 819

  Fly   745 EMRHVRR----------PMPAQRGTSGKSSFSTRPSSRNPASSNANPFXHKI 786
            |..|..|          |.....||:     .|.|.|...:...:.||.:.:
Zfish   820 EQSHCGRGGKVPKIKSSPQKVSHGTA-----LTAPPSPTASKPPSFPFQNNV 866

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BicD	NP_001260531.1	BicD	80..742	CDD:286773	276/769 (36%)
bicd1a	XP_684729.2	BicD	75..817	CDD:286773	276/770 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592568
Domainoid	1	1.000	416	1.000	Domainoid score	I631
eggNOG	1	0.900	-	-		E1_KOG0999
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	473	1.000	Inparanoid score	I1462
OMA	1	1.010	-	-		QHG48464
OrthoDB	1	1.010	-	-		D250005at33208
OrthoFinder	1	1.000	-	-		FOG0001590
OrthoInspector	1	1.000	-	-		otm24786
orthoMCL	1	0.900	-	-		OOG6_104968
Panther	1	1.100	-	-	O	PTHR31233
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4141
SonicParanoid	1	1.000	-	-		X1419
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.800