Protein Alignment BicD and Bicd1

DIOPT Version :10

• Sequence 1: NP_001260531.1
• Gene: BicD / 35051
• FlyBaseID: FBgn0000183
• Length: 802
• Species: Drosophila melanogaster
• Sequence 2: XP_006237765.1
• Gene: Bicd1 / 362466
• RGDID: 1309444
• Length: 975
• Species: Rattus norvegicus
• Alignment Length: 849
• Identity: 332/849 - (39%)
• Similarity: 492/849 - (57%)
• Gaps: 113/849 - (13%)

  Fly    13 QSVQDLQMEVERLTRELDQVSSASAQSAQYGLSLLEEKSALQQKCEELETLYDNTRHELDITQEA 77
            ::|...:.|:||||:||.:.:....|:|:|||.:||||..|:|:.:|||..||..:.||:..:||
  Rat     8 KTVDHYKTEIERLTKELTETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYDGLKQELEQLKEA 72

  Fly    78 L-TKFQTSQKVTNKTGIEQEDALLNESAARETSLNLQIFDLENELKQLRHELERVRNERDRM--- 138
            . ..|...:||. :.|..:|:.||.|||::|.....:|.:::|||||.|..:..|:.|.:|:
  Rat    73 FGQSFSIHRKVA-EDGETREETLLQESASKEAYYLNKILEMQNELKQSRAVVTNVQAENERLSAV 136

  Fly   139 ---LQENSDFGRDKSDSEADRLRLKSELKDLKFRETRMLSEYSELEEENISLQKQVSSLRSSQVE 200
               |:||::.      .|..|:|:|.|:::.||||.|:|.:|:|||||||:|||.||:|:.:|||
  Rat   137 VQELKENNEM------VELQRIRMKDEIREYKFREARLLQDYTELEEENITLQKLVSTLKQNQVE 195

  Fly   201 FEGAKHEIRRLTEEVELLNQQVDELANLKKIAEKQMEEALETLQGEREAKYALKKELDGHLNRES 265
            :||.||||:|..||..|||.|:::...||:|||.|:|||||||:.|||.|..|:|||..:::. |
  Rat   196 YEGLKHEIKRFEEETVLLNSQLEDAIRLKEIAEHQLEEALETLKNEREQKNNLRKELSQYISL-S 259

  Fly   266 MYHISNLAYSIRSNMEDNASNNSDGEEENL--ALKRLEADLSTELKSPDGTK-------CDLFSE 321
            ..|||.....::...:.:..||.|....:|  .|.:|..|    .::|...|       .|||||
  Rat   260 DNHISISVEGLKFAEDGSEPNNDDKMNGHLHGPLGKLNGD----YRAPTARKGESLHPVSDLFSE 320

  Fly   322 IHLNELKKLEKQLESMESEKTHLTANLREAQTSLDKSQNELQNFMSRLALLAAHVDAL------V 380
            ::::|::||::||..:|.||..|.|||:|:||.|:.::..|.....|:..|..||:|:      .
  Rat   321 LNISEIQKLKQQLIQVEREKAILLANLQESQTQLEHTKGALTEQHERVHRLTEHVNAMRGLQNSK 385

  Fly   381 QLKKQIDVKEQGKEGGQKKDELEQQLRALISQYANWFTLSAKEIDGLKTDIAELQKGL-----NY 440
            :||.::|. |:|:...::..:.|..:..|...... :.::..|:..||.:|..|::..     ||
  Rat   386 ELKAELDC-EKGRNSAEEAHDYEVDINGLEILECK-YRVAVTEVIDLKAEIKALKEKYNKSVENY 448

  Fly   441 TDATTTLRN-------EVTNLKNKLLATEQKSLDLQSDVQTLTHISQNAGQSLGSARSTLVALSD 498
            |:..|...:       :||||:.....:.:|...::.::|.:|.|:.....:|.:|:..||..|:
  Rat   449 TEEKTKYESKIQMYDEQVTNLEKTSKESGEKMAHMEKELQKMTGIANENHNTLNTAQDELVTFSE 513

  Fly   499 DLAQLYHLVCTVNGETPTRVLLDH---------------------------------------KT 524
            :||||||.||..|.|||.||:||:                                       .:
  Rat   514 ELAQLYHHVCLCNNETPNRVMLDYYRQSRVTRSGSLKGPDDPRGLLSPRLSRRGVSSPVESRTSS 578

  Fly   525 DDMSFENDSLTAIQSQFK----SDVFIAKPQIVEDLQGLADSVEIKK-------YVDTVSDQIKY 578
            :.:|.||...:...|..|    |.|..|.|.     ..:.|:.:|:|       ....:.||||:
  Rat   579 EPVSKENTETSKEPSPTKTPTISPVITAPPS-----SPVLDTSDIRKEPMNIYNLNAIIRDQIKH 638

  Fly   579 LKTAVEHTIDMNKHKIRSEGGDALEKVNTEEMEELQEQIVKLKSLLSVKREQIGTLRNVLKSNKQ 643
            |:.||:.::.:::.:..:.   .|..:..::.|.|.|:|:|||||||.|||||.|||.|||:|||
  Rat   639 LQKAVDRSLQLSRQRAAAR---ELAPMIDKDKEALMEEILKLKSLLSTKREQIATLRAVLKANKQ 700

  Fly   644 TAEVALTNLKSKYENEKIIVSDTMSKLRNELRLLKEDAATFSSLRAMFAARCEEYVTQVDDLNRQ 708
            ||||||.|||:||||||.:|::||:||||||:.||||||||||||||||.||:|||||:|::.||
  Rat   701 TAEVALANLKNKYENEKAMVTETMTKLRNELKALKEDAATFSSLRAMFATRCDEYVTQLDEMQRQ 765

  Fly   709 LEAAEEEKKTLNQLLRLAVQQKLALTQRLEEMEMDREMRHVRRPMPAQRGTSGKSSF-STRPSSR 772
            |.|||:||||||.|||:|:|||||||||||::|.|.|..  ||    .:|..|||.. |.:.|..
  Rat   766 LAAAEDEKKTLNTLLRMAIQQKLALTQRLEDLEFDHEQS--RR----SKGKLGKSKIGSPKVSGE 824

  Fly   773 NPAS 776
            .||:
  Rat   825 APAT 828

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
BicD	NP_001260531.1	SMC_prok_B	<10..138	CDD:274008	48/125 (38%)
		BicD	83..741	CDD:462863	290/740 (39%)
Bicd1	XP_006237765.1	BicD	74..799	CDD:462863	291/746 (39%)