DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment BicD and bicd1

DIOPT Version :9

Sequence 1:	NP_001260531.1	Gene:	BicD / 35051	FlyBaseID:	FBgn0000183	Length:	802	Species:	Drosophila melanogaster
Sequence 2:	XP_031754367.1	Gene:	bicd1 / 100493367	XenbaseID:	XB-GENE-22068032	Length:	1037	Species:	Xenopus tropicalis

Alignment Length:	894	Identity:	328/894 - (36%)
Similarity:	504/894 - (56%)	Gaps:	135/894 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 QSVQDLQMEVERLTRELDQVSSASAQSAQYGLSLLEEKSALQQKCEELETLYDNTRHELDITQEA 77
            |:|:|.:.|:||||:||.:.:....|:|:|||.:||||.:|:|:.::||:..|:.|.|||..:||
Frog    34 QTVEDYKAEIERLTKELAETTQEKIQAAEYGLVVLEEKLSLKQQYDDLESDCDSLRQELDQLKEA 98

  Fly    78 LTKFQTSQKVTNKTGIEQEDALLNESAARETSLNLQIFDLENELKQLRHELERVRNERDRMLQEN 142
            ..:..|..:...:.|..:|:.||.|||::|.....:|.:::||:||.|..:..|:.|.:|:....
Frog    99 FGQSFTVHRKVAEDGETREETLLQESASKEEYYLGRILEMQNEVKQSRAAITNVQGENERLSSVV 163

  Fly   143 SDFGRDKSDSEADRLRLKSELKDLKFRETRMLSEYSELEEENISLQKQVSSLRSSQVEFEGAKHE 207
            .|........|..|||:|.|:::.||||.|:|.:|:|||||||:|||.||:|:.:|||:||.|||
Frog   164 QDLKETNEILELQRLRMKDEIREYKFREARLLQDYTELEEENITLQKLVSTLKQNQVEYEGLKHE 228

  Fly   208 IRRLTEEVELLNQQVDELANLKKIAEKQMEEALETLQGEREAKYALKKELDGHLN-RESMY---- 267
            |:|..|:..|||.|:::...||:|:|.|:|||||||:.|||.|..|:|||..::| .:|||
Frog   229 IKRFEEDTVLLNSQLEDAIRLKEISEHQLEEALETLKNEREQKNNLRKELAQYININDSMYNNHL 293

  Fly   268 HISNLAYSIRSNMEDNASNNSDGEEENL--ALKRLEADLSTELKSPDGTK--------CDLFSEI 322
            ::..|.:|     ||...||.|....::  .|.:|..|..|:     .|:        .|||||:
Frog   294 NLDGLKFS-----EDGEPNNEDKVNGHIHTPLVKLNGDYRTQ-----ATRKGESLHPVSDLFSEL 348

  Fly   323 HLNELKKLEKQLESMESEKTHLTANLREAQTSLDKSQNELQNFMSRLALLAAHVDALVQLKK-QI 386
            :::|::||::||..:|.||..|..|.:|:||.|:.::..|.....|:..|..||:|:.:|.. ::
Frog   349 NISEMQKLKQQLIQVEREKALLLTNFQESQTQLEHTKGALTEQHDRVHRLTEHVNAMRKLHSIEL 413

  Fly   387 DVKEQGKEGGQKKDELEQQLRALISQYANWFTLSAKEIDGLKTDIAELQKGLN-----YTDATTT 446
            | .|:.|..|::..:.|..:..|...... :.::..|:..||.::..|::..|     |::..:.
Frog   414 D-SEKPKVSGEENHDYEVDINGLEILECK-YKVAVTEVIDLKAELKALKEKYNKHVETYSEERSK 476

  Fly   447 LRN-------EVTNLKNKLLATEQKSLDLQSDVQTLTHISQNAGQSLGSARSTLVALSDDLAQLY 504
            |.:       :|..|:.....:.:|.|.::.::|.:|.|:.....:|.:|:..||..|::|||||
Frog   477 LDSRIQMYDEQVGGLERASKESCEKVLVMEKELQIMTAIANETHNTLNTAQDELVTFSEELAQLY 541

  Fly   505 HLVCTVNGETPTRVLLDHKTDDMSFENDSL----------------------------------- 534
            |.||..|.|||.||:||:........:.||
Frog   542 HHVCLCNNETPNRVMLDYYRQSKVTRSGSLKGPDDPRGLLSPRLVRRGMASPVDLRSPCEPGPKE 606

  Fly   535 --------TAIQSQFKSDVFIAKPQIVEDLQGLADSVEIKK-------YVDTVSDQIKYLKTAVE 584
                    :.::|...:.:..|.|.     ..::|:.:|:|       ....:.||||:|:.||:
Frog   607 TMESSKEQSPLKSSMVTPIITAPPS-----SPVSDTSDIRKEPMNIYNLNAIIRDQIKHLQKAVD 666

  Fly   585 HTIDMNKHKIRSEGGDALEKVNTEEMEELQEQIVKLKSLLSVKREQIGTLRNVLKSNKQTAEVAL 649
            .::.:::.:..:.   .|..:..::.|.|.|:|:|||||||.|||||.|||.|||:|||||||||
Frog   667 KSLQLSRQRAAAR---ELAPMIDKDKEALMEEILKLKSLLSTKREQIATLRAVLKANKQTAEVAL 728

  Fly   650 TNLKSKYENEKIIVSDTMSKLRNELRLLKEDAATFSSLRAMFAARCEEYVTQVDDLNRQLEAAEE 714
            .|||:||||||.:|::||:||||||:.||||||||||||||||.||:|||||:|::.|||.|||:
Frog   729 ANLKNKYENEKTMVTETMTKLRNELKALKEDAATFSSLRAMFATRCDEYVTQLDEMQRQLAAAED 793

  Fly   715 EKKTLNQLLRLAVQQKLALTQRLEEMEMDREMR-------------------HVRRPMPA----- 755
            ||||||.|||:|:|||||||||||::|.|.|..                   ..|:|:.:
Frog   794 EKKTLNSLLRMAIQQKLALTQRLEDLEFDHEQSWRTKGKLGKSKIGSPKQFPEARKPLQSHYSSS 858

  Fly   756 ---------QRGTSGKSSFSTRPSSRNPASS---NANPFXHKISVQRKL 792
                     |.|||.:|| :...|..:|.||   :::.| |::.:.|.|
Frog   859 SSRLAFQAHQDGTSLRSS-AALLSPLSPKSSPETSSSLFFHQLPLSRSL 906

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BicD	NP_001260531.1	BicD	80..742	CDD:286773	279/739 (38%)
bicd1	XP_031754367.1	BicD	100..821	CDD:370639	279/740 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	439	1.000	Domainoid score	I545
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	500	1.000	Inparanoid score	I1332
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250005at33208
OrthoFinder	1	1.000	-	-		FOG0001590
OrthoInspector	1	1.000	-	-		otm49343
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1419
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	7.060