DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment BicD and bicd2l

DIOPT Version :9

Sequence 1:	NP_001260531.1	Gene:	BicD / 35051	FlyBaseID:	FBgn0000183	Length:	802	Species:	Drosophila melanogaster
Sequence 2:	XP_002935257.1	Gene:	bicd2l / 100327237	XenbaseID:	XB-GENE-995877	Length:	764	Species:	Xenopus tropicalis

Alignment Length:	811	Identity:	306/811 - (37%)
Similarity:	467/811 - (57%)	Gaps:	114/811 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 ADQSVQDLQMEVERLTRELDQVSSASAQSAQYGLSLLEEKSALQQKCEELETLYDNTRHELDITQ 75
            |::.:..|:.|::||:.||.:.::...|:|||||::|||.|.|::|..:|::..:..:.||...:
Frog     2 AEEEIVILRAELDRLSAELQETTADKLQAAQYGLAVLEENSELKRKNSDLDSECELLKLELKQMK 66

  Fly    76 EALTKFQTSQKVTNKTGIEQEDALLNESAARETSLNLQIFDLENELKQLRHELERVRNERDRMLQ 140
            |||.:.||:.|.|.:.|..:|:.||.|:|:||..|:.:|.:|.:|||||:.......:|.:|:..
Frog    67 EALAESQTNHKRTAEDGESREENLLKEAASREAKLSDKIDELHSELKQLKSFRTNTTSENERLHL 131

  Fly   141 ENSDFGRDKSDSEADRLRLKSELKDLKFRETRMLSEYSELEEENISLQKQVSSLRSSQVEFEGAK 205
            ...:..::..::|.::.:|:.|:|..|..|.|.|.::|:||||||||.||||.|:.:||||||.|
Frog   132 VIQNIKKEYGETEKEKAKLREEIKQCKISEMRQLQDFSDLEEENISLLKQVSILKENQVEFEGIK 196

  Fly   206 HEIRRLTEEVELLNQQVDELANLKKIAEKQMEEALETLQGEREAKYALKKELDGHLNRESMYHIS 270
            ||::|..||:::||..|:||..|:.|:|:|:|||||:|:.|||.|..|::||...||.:|   :.
Frog   197 HELKRRAEEIDVLNGNVEELMRLRDISERQLEEALESLKSEREQKKELQRELSAFLNYDS---VG 258

  Fly   271 NLAYSIRSNMEDNASNNSDGEEE-----NLALKRLEADL------STELKSPDGTKC--DLFSEI 322
            ||    ..|.||:      .|||     |..:.:...::      ::::..| |.|.  :||:|:
Frog   259 NL----HGNFEDH------NEEEFDSGYNFGISKTNGEILMSTPRNSDIYHP-GPKAALNLFTEL 312

  Fly   323 HLNELKKLEKQLESMESEKTHLTANLREAQTSLDKSQNELQNFMSRLALLAAHVDALVQLKKQID 387
            :|.|::||::||..::.||..:.|:|...:.:||.:...|.....:...|...::|   ||:.:|
Frog   313 NLPEIQKLQQQLLQVDREKASVMADLEGLKNNLDVATEALSKEQKQNGELLEQINA---LKEDLD 374

  Fly   388 ----------VKEQGKEGGQKKDELEQQLRALISQYANWFTLSAKEIDGLKTDIAELQKGLNYTD 442
                      .|.|.|:...:...|:::|:.|:.||.:    ..|:   .|.:.||.:..:
Frog   375 NSGRKCETEVFKCQCKQENTEASRLKKELKELLQQYQD----LKKQ---YKDEKAEWEASM---- 428

  Fly   443 ATTTLRNEVT---NLKNKLLATEQKSL-DLQSDVQTLTHISQNAGQSLGSARSTLVALSDDLAQL 503
                  .|||   :|..|...::|..| :||.|::||.....:....|..|:..|::.:::||.|
Frog   429 ------QEVTERLSLYMKCERSDQGLLGELQEDLKTLRRSYCDVQSKLNLAQDELMSFTEELAHL 487

  Fly   504 YHLVCTVNGETPTRVLLDHKTDDMSFENDSLTAIQSQFKSDVF---IAKP--QIVE-------DL 556
            ||.||..|..||.||:||:..|.    ..|....:.:..||.|   :..|  :|.|       .|
Frog   488 YHHVCMRNSLTPNRVMLDYYRDG----KGSKLHFRKRKSSDFFGKLLVSPDMEITEIHSGECSPL 548

  Fly   557 QGLADSV------------EIKKYVDTVSDQIKYLKTAV----EHTIDMNKHKIRSEGGDALEKV 605
            ...|.|:            .|...:..|.||||:|:.|:    :||              :||.:
Frog   549 SSPASSIGSDCGDSSREPLSITHLIAIVKDQIKHLQGAIVVSWQHT--------------SLESI 599

  Fly   606 NTE---EMEELQEQIVKLKSLLSVKREQIGTLRNVLKSNKQTAEVALTNLKSKYENEKIIVSDTM 667
            .:|   :.|.|.::|:|||||||.|||||.|||.|||:||||||||::||||||||||.:|||||
Frog   600 ASEMDKDKEVLVDEIMKLKSLLSTKREQIATLRTVLKANKQTAEVAMSNLKSKYENEKALVSDTM 664

  Fly   668 SKLRNELRLLKEDAATFSSLRAMFAARCEEYVTQVDDLNRQLEAAEEEKKTLNQLLRLAVQQKLA 732
            .|||:||:.||||||||||||::||:||::||||::::.|||.|||:||||||.|||:|:|||||
Frog   665 VKLRHELKALKEDAATFSSLRSLFASRCDQYVTQLEEMQRQLAAAEDEKKTLNSLLRMAIQQKLA 729

  Fly   733 LTQRLEEMEMDREMRHVRRPMPAQRGTSGKS 763
            ||||||    .||..|......::..|.||:
Frog   730 LTQRLE----GREGAHNASKSHSKSSTKGKT 756

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BicD	NP_001260531.1	BicD	80..742	CDD:286773	275/719 (38%)
bicd2l	XP_002935257.1	BicD	70..738	CDD:370639	275/723 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	439	1.000	Domainoid score	I545
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	500	1.000	Inparanoid score	I1332
OMA	1	1.010	-	-		QHG48464
OrthoDB	1	1.010	-	-		D250005at33208
OrthoFinder	1	1.000	-	-		FOG0001590
OrthoInspector	1	1.000	-	-		otm49343
Panther	1	1.100	-	-	LDO	PTHR31233
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4141
SonicParanoid	1	1.000	-	-		X1419
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.110