DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SPH93 and gzma

DIOPT Version :9

Sequence 1:	NP_609840.1	Gene:	SPH93 / 35049	FlyBaseID:	FBgn0032638	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	XP_001335166.1	Gene:	gzma / 795070	ZFINID:	ZDB-GENE-091204-156	Length:	257	Species:	Danio rerio

Alignment Length:	248	Identity:	71/248 - (28%)
Similarity:	111/248 - (44%)	Gaps:	46/248 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   259 WAVAIFHNGQYLAGGSLIQPNVVLTVAHRVITIETELVVRAGDWDLKSDREIFLSEQREVERAVI 323
            |.|:|..|..:..||.||....|||.||......:.:.|..|.          ||..:..:|..|
Zfish    40 WMVSIQVNQNHKCGGILIHKEWVLTAAHCKEDSYSSVTVLIGS----------LSLSKGSQRIAI 94

  Fly   324 H-----EGFDFKSGANNLALLFLN-----SPFKLNDHIRTICLPTPNKSF-AGRRCTVAGWGKMR 377
            |     |.|:.|:..:::.|:.|:     .|:|         :|...|.. .|.:|.|.|||...
Zfish    95 HNYEIPETFNKKTKKDDIMLIRLSKKVKAKPYK---------IPKKEKDVQPGTKCVVRGWGTTD 150

  Fly   378 YEDQRYSTVLKKVQLLVVNRNVCEKFLRSTRLGAKFELPKNIICAGG-ELGRDTCTGDGGSALFC 441
            |:.::.|..|:.:::|||:|..|.::.....:     :.|:::|||. :..|.||.||.|..|.|
Zfish   151 YKGKQASDKLQMLEVLVVDRVQCNRYYNRNPV-----ITKDMLCAGNTQQHRGTCLGDSGGPLEC 210

  Fly   442 SIGGENSGVYEQAGIVNWGVGCGQEGIPAIYTEVSK-FTNWITEKLLPFDYRS 493
                |.:.|    |:::...|||....|.:||.:|| ...|| .|:|...:.|
Zfish   211 ----EKNLV----GVLSGSHGCGDPKKPTVYTLLSKRHITWI-NKILKQQFNS 254

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SPH93	NP_609840.1	GRP	<136..189	CDD:254089
		Tryp_SPc	250..485	CDD:238113	68/238 (29%)
		Tryp_SPc	252..482	CDD:214473	66/235 (28%)
gzma	XP_001335166.1	Tryp_SPc	28..247	CDD:238113	68/239 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170587517
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930