DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SPH93 and CG8586

DIOPT Version :9

Sequence 1:	NP_609840.1	Gene:	SPH93 / 35049	FlyBaseID:	FBgn0032638	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	NP_001286204.1	Gene:	CG8586 / 35854	FlyBaseID:	FBgn0033320	Length:	444	Species:	Drosophila melanogaster

Alignment Length:	475	Identity:	142/475 - (29%)
Similarity:	200/475 - (42%)	Gaps:	123/475 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 RSSN-CGNTKICC--------------------AVLRKPGGTVLIEPNGPEDDKVGVNGINAQLS 84
            |||. ||..::||                    :.:|....:|| ||  |.::..|.   |.:..
  Fly    54 RSSRICGTQRVCCEKAQLDSYDRWLVERTTTVPSTIRNKVSSVL-EP--PPNESCGQ---NMECV 112

  Fly    85 PTRELTRDRPNTIESQVKEINDFSGRPTNNERNPATEPNNGGYTTPNGGYPVNNGGYPVNNGGYP 149
            | |:|.||         ..||| ||....|.|....:.:...|........|::...|
  Fly   113 P-RKLCRD---------NIIND-SGISLINPRISPIQCSKSLYRCCAVDQKVDDSESP------- 159

  Fly   150 SNNGGYPSNNGGYPVNNGGYPVNNGGYPANNGGYPANNGGYPTTNVGNPTNNGGNPTTNFGNPTN 214
                        |.|....:...|.|| :|..|...:|..:|.:
  Fly   160 ------------YLVKQANFKYKNCGY-SNPKGLIPDNDKFPYS--------------------- 190

  Fly   215 NGGNPTTNVGSSELLSPSCGMSNANGLQMVEGITIDQARPAQYPWAVAIFHNGQ-YLAGGSLIQP 278
                                          |.::|.    .::||.|.||...| :|.||:||.|
  Fly   191 ------------------------------EDVSIF----GEFPWMVGIFTGRQEFLCGGTLIHP 221

  Fly   279 NVVLTVAHRVI--TIETELVVRAGDWDLKSDREIFLSEQREVERAVIHEGFDFKSGANNLALLFL 341
            .:|:|.:|.::  |::| ||.|||||||.|..|.:..:...::..::|..||..|..|::|||.|
  Fly   222 RLVVTTSHNLVNETVDT-LVARAGDWDLNSLNEPYPHQGSRIKEIIMHSEFDPNSLYNDIALLLL 285

  Fly   342 NSPFKLNDHIRTICLPTP-----NKSFAGRRCTVAGWGKMRYEDQRYSTVLKKVQLLVVNRNVCE 401
            :.|.:|..||:.:|||.|     ........|...|||.......:...|||::.|.:|.|..|:
  Fly   286 DEPIRLAPHIQPLCLPPPESPELTNQLLSVTCYATGWGTKEAGSDKLEHVLKRINLPLVEREECQ 350

  Fly   402 KFLRSTRLGAKFELPKNIICAGGELGRDTCTGDGGSALFCSIGGENSGVYEQAGIVNWGVGCGQE 466
            ..||:|||.|:|.|..:.|||||:.|:|||.|||||.|||.:.||... |:..|||:|||.|..|
  Fly   351 AKLRNTRLEARFRLRPSFICAGGDPGKDTCKGDGGSPLFCQMPGEMDR-YQLVGIVSWGVECAVE 414

  Fly   467 GIPAIYTEVSKFTNWITEKL 486
            .|||:|..|.....||.||:
  Fly   415 DIPAVYVNVPHLRGWIDEKI 434

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SPH93	NP_609840.1	GRP	<136..189	CDD:254089	10/52 (19%)
		Tryp_SPc	250..485	CDD:238113	99/242 (41%)
		Tryp_SPc	252..482	CDD:214473	97/237 (41%)
CG8586	NP_001286204.1	Tryp_SPc	197..433	CDD:238113	99/237 (42%)
CG8586	NP_001286204.1	Tryp_SPc	197..430	CDD:214473	97/234 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45457418
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BM7R
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	132	1.000	Inparanoid score	I4490
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D23222at50557
OrthoFinder	1	1.000	-	-		FOG0003848
OrthoInspector	1	1.000	-	-		mtm8716
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24256
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	8	7.900