DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SPH93 and CG18563

DIOPT Version :9

Sequence 1:	NP_609840.1	Gene:	SPH93 / 35049	FlyBaseID:	FBgn0032638	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	NP_609841.2	Gene:	CG18563 / 35050	FlyBaseID:	FBgn0032639	Length:	379	Species:	Drosophila melanogaster

Alignment Length:	487	Identity:	161/487 - (33%)
Similarity:	223/487 - (45%)	Gaps:	117/487 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 AIGTLLLASVLMGNACRHTCVTRNFCLYEEPTFDYRSSNCGNTKICC-AVLRKPGGTVLIEPNGP 69
            |...:||..||.|.|||: ||....||    ....:.::|....:|| .:::.|     ..|:||
  Fly     6 ATAAILLFCVLSGEACRY-CVPMEKCL----ILSRKLNSCPFNHVCCDIIIKSP-----YIPSGP 60

  Fly    70 EDDKVGVNGINAQLSPTRELTRDRPNTIESQVKEINDFSGRPTNNERNPATEPNNGGYTTPNGGY 134
            .::....:..:              :|.|..:.....|..|||     .::||.|...|.|:  .
  Fly    61 NEESDSESASS--------------STEEENIPTFIYFPTRPT-----VSSEPQNNVSTEPD--V 104

  Fly   135 PVNNGGYPVNNGGYPSNNGGYPSNNGGYPVNNGGYPVNNGGYPANNGGYPANNGGYPTTNVGNPT 199
            |:..  :|:...|.|:|:|.....                                     ..||
  Fly   105 PITY--WPLKGSGAPTNDGAQAEQ-------------------------------------PKPT 130

  Fly   200 NNGGNPTTNFGNPTNNGGNPTTNVGSSELLSPSCGMSNANGLQMVEGITIDQARPAQYPWAVAIF 264
            ..           |..||.              |   |..||               |.|.||:|
  Fly   131 ER-----------TQPGGR--------------C---NTTGL---------------YSWVVALF 152

  Fly   265 HNGQYLAGGSLIQPNVVLTVAHRVIT--IETELVVRAGDWDLKSDREIFLSEQREVERAVIHEGF 327
            :...||.|||||.|.|:||.||..:.  .|..:|||||::.:.:..|....|:|.|||.|.||||
  Fly   153 YEEVYLTGGSLISPKVILTAAHNTMNKMNEDRIVVRAGEFVMNTTNEPIQYEERVVERIVRHEGF 217

  Fly   328 DFKSGANNLALLFLNSPFKLNDHIRTICLPTPNKSFAGRRCTVAGWGKMRYEDQRYSTVLKKVQL 392
            .|:||.||:||:|:.:||.|||.|..:.||:...||.|||||||||..:...||....::||::|
  Fly   218 IFQSGINNVALIFVKTPFVLNDRIGVLTLPSRQASFEGRRCTVAGWDLVSSHDQSRMRIIKKLEL 282

  Fly   393 LVVNRNVCEKFLRSTRLGAKFELPKNIICAGGELGRDTCTGDGGSALFCSIGGENSGVYEQAGIV 457
            .|::|..|....|:|.||..|:|..::|||..|:.||.|.|.||.|||||:|.||..|:||||||
  Fly   283 TVLDRTTCVAQFRNTTLGRNFDLHPSLICARSEINRDFCFGGGGYALFCSLGDENPHVFEQAGIV 347

  Fly   458 NWGVGCGQEGIPAIYTEVSKFTNWITEKLLPF 489
            .||:|||.: :|.|||.|:.|.:||..::..|
  Fly   348 AWGMGCGLD-LPGIYTNVAMFRSWIYNRIAYF 378

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SPH93	NP_609840.1	GRP	<136..189	CDD:254089	5/52 (10%)
		Tryp_SPc	250..485	CDD:238113	114/236 (48%)
		Tryp_SPc	252..482	CDD:214473	112/231 (48%)
CG18563	NP_609841.2	Tryp_SPc	147..373	CDD:238113	113/226 (50%)
CG18563	NP_609841.2	Tryp_SPc	147..371	CDD:214473	111/224 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45471494
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BM7R
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003848
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24256
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.840