DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SPH93 and TPSG1

DIOPT Version :9

Sequence 1:	NP_609840.1	Gene:	SPH93 / 35049	FlyBaseID:	FBgn0032638	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	XP_011520748.1	Gene:	TPSG1 / 25823	HGNCID:	14134	Length:	346	Species:	Homo sapiens

Alignment Length:	299	Identity:	91/299 - (30%)
Similarity:	139/299 - (46%)	Gaps:	54/299 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   201 NGGNPTTNFGNPTNNGGNPTTNVGSSELLSPSCG---MSNANGLQMVEGITIDQARPA-QYPWAV 261
            :||:.....|:|.   |.|:    |.:|   .||   :|:|.| ::|.|    .|.|| .:||..
Human    29 HGGSAVGFLGSPP---GTPS----SFDL---GCGRPQVSDAGG-RIVGG----HAAPAGAWPWQA 78

  Fly   262 AIFHNGQYLAGGSLIQPNVVLTVAHRVITIETELVVRAGDWDLKSDREIFLSEQR--------EV 318
            ::.....::.||||:.|..|||.||          ..:|..: .||.::.|.|..        .|
Human    79 SLRLRRVHVCGGSLLSPQWVLTAAH----------CFSGSLN-SSDYQVHLGELEITLSPHFSTV 132

  Fly   319 ERAVIHEGFDFKSG-ANNLALLFLNSPFKLNDHIRTICLPTPNKSFA-GRRCTVAGWGKMRYED- 380
            .:.::|.....:.| :.::||:.|:.|..|:..|..:|||..:..|. |.||.|.|||..|..:
Human   133 RQIILHSSPSGQPGTSGDIALVELSVPVTLSSRILPVCLPEASDDFCPGIRCWVTGWGYTREGEP 197

  Fly   381 --QRYSTVLKKVQLLVVNRNVCEKFLRSTRLGAKFELPKNIICAGGELGRDTCTGDGGSALFCSI 443
              ..||  |::|::.||:...|.:.....  |... |..:::||.|.  .|.|..|.|..|.|.:
Human   198 LPPPYS--LREVKVSVVDTETCRRDYPGP--GGSI-LQPDMLCARGP--GDACQDDSGGPLVCQV 255

  Fly   444 GGENSGVYEQAGIVNWGVGCGQEGIPAIYTEVSKFTNWI 482
                :|.:.|||.|:||.|||:...|.:||.|..:.|||
Human   256 ----NGAWVQAGTVSWGEGCGRPNRPGVYTRVPAYVNWI 290

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SPH93	NP_609840.1	GRP	<136..189	CDD:254089
		Tryp_SPc	250..485	CDD:238113	76/247 (31%)
		Tryp_SPc	252..482	CDD:214473	74/243 (30%)
TPSG1	XP_011520748.1	Tryp_SPc	62..290	CDD:214473	76/253 (30%)
TPSG1	XP_011520748.1	Tryp_SPc	63..293	CDD:238113	78/254 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152822
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840