DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SPH93 and Prss28

DIOPT Version :9

Sequence 1:	NP_609840.1	Gene:	SPH93 / 35049	FlyBaseID:	FBgn0032638	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	NP_444489.2	Gene:	Prss28 / 114661	MGIID:	2149951	Length:	274	Species:	Mus musculus

Alignment Length:	294	Identity:	70/294 - (23%)
Similarity:	136/294 - (46%)	Gaps:	61/294 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   228 LLSPSCGMSNANGLQMVEGITIDQAR-----------PAQYPWAVAI------FHNGQYLAGGSL 275
            ||:.||..|..    .:..::|.:::           |.::||.|::      .::..::.|||:
Mouse     6 LLALSCLESTV----FMASVSISRSKPVGIVGGQCTPPGKWPWQVSLRMYSYEVNSWVHICGGSI 66

  Fly   276 IQPNVVLTVAHRVITIETELV---VRAGDWDLKSDREIFLSEQRE---VERAVIHEGFDFKSGAN 334
            |.|..:||.||.:.:.:.:..   |:.|        |::|.:::|   :.|.:||..::..|...
Mouse    67 IHPQWILTAAHCIQSQDADPAVYRVQVG--------EVYLYKEQELLNISRIIIHPDYNDVSKRF 123

  Fly   335 NLALLFLNSPFKLNDHIRTICLPTPNKSF-AGRRCTVAGWGKMRYEDQR------YSTVLKKVQL 392
            :|||:.|.:....:.::..:.||..:.:| :..:|.:.|||.:.   ||      |.  |.:|::
Mouse   124 DLALMQLTALLVTSTNVSPVSLPKDSSTFDSTDQCWLVGWGNLL---QRVPLQPPYQ--LHEVKI 183

  Fly   393 LVVNRNVCEKFLRST-----RLGAKFELPKNIICAGGELGRDTCTGDGGSALFCSIGGENSGVYE 452
            .:.:...|::..|..     :..|.|:   :::|||.. ||..|.||.|..|.|    ..|..:.
Mouse   184 PIQDNKSCKRAYRKKSSDEHKAVAIFD---DMLCAGTS-GRGPCFGDSGGPLVC----WKSNKWI 240

  Fly   453 QAGIVNWGVGCGQEGIPAIYTEVSKFTNWITEKL 486
            |.|:|:.|:.| ...:|:|::.|.....||.:.:
Mouse   241 QVGVVSKGIDC-SNNLPSIFSRVQSSLAWIHQHI 273

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SPH93	NP_609840.1	GRP	<136..189	CDD:254089
		Tryp_SPc	250..485	CDD:238113	64/269 (24%)
		Tryp_SPc	252..482	CDD:214473	62/264 (23%)
Prss28	NP_444489.2	Tryp_SPc	31..272	CDD:238113	64/262 (24%)
Prss28	NP_444489.2	Tryp_SPc	31..269	CDD:214473	62/259 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842928
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840